期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 28, 期 60, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202201829
关键词
allylic alcohols; allylic amines; borrowing hydrogen; iron catalysts; tert-butylsulfinamides
资金
- National Natural Science Foundation of China [22172096, 21773145]
- Projects for the Academic Leaders and Academic Backbones, Shaanxi Normal University [16QNGG008]
- Fundamental Research Funds for the Central Universities [GK202002003]
- Natural Science Basic Research Program of Shaanxi [2021JC-30]
A Fe-catalyzed amidation of allylic alcohols with chiral tert-butylsulfinamide has been developed for the synthesis of chiral sulfinamide olefin derivatives. The reaction proceeds under mild conditions with water as the only by-product.
Allylic amines are useful building blocks in organic synthesis, so the development of green and efficient methods for the preparation of allylic amines are of great importance. An Fe-catalyzed amidation of allylic alcohols with chiral tert-butylsulfinamide has been developed. With water as the only by-product, a range of synthetically useful chiral sulfinamide olefin derivatives (30 examples) were obtained under mild reaction conditions. The reaction can be performed on a gram-scale, and the products could serve as chiral ligands for asymmetric catalysis. Mechanistic studies suggest that the reaction proceeds by an Fe-catalyzed borrowing hydrogen process, which is different from most of the reported allylic amination reactions.
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