期刊
CHEMISTRY OF MATERIALS
卷 34, 期 17, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.2c01024
关键词
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资金
- National Research Foundation (NRF) , Republic of Korea [2019H1D3A1A01071101, 2018R1A2B3006080, 2022R1I1A1A01056847]
- Korea Basic Science Institute (National Research Facilities and Equipment Center) grant - Ministry of Education [2020R1A6C101A191]
- National Research Foundation of Korea [2022R1I1A1A01056847, 2019H1D3A1A01071101] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Chemiluminescence is a favorable technique for reactive oxygen species (ROS) imaging, but its short duration limits its clinical applications. In this work, nanoparticles consisting of a self-immolative polymer (SIP) and hydrophobic dyes are discovered to induce sustained chemiluminescence, which is available for long-term in vivo ROS imaging. These SIP-based nanoparticles generate highly efficient ROS-selective chemiluminescence signals and have potential as contrast agents for in vivo disease diagnosis.
Chemiluminescence (CL) provides a favorable technique for reactive oxygen species (ROS) imaging with high specificity and negligible background noise; however, the short duration limits its clinical applications in disease diagnosis. In this work, we serendipitously discover that the nanoparticles (NPs), consisting of a self-immolative polymer (SIP) and hydrophobic dyes, induce sustained CL, which is available for long-term in vivo ROS imaging. In response to ROS, SIP undergoes stepwise head-to-tail degradation and sustainably transfers energy to the dyes to emit CL. With this unique domino-like degradation mechanism, the SIP-based CL-NPs generate highly efficient ROS-selective CL signals for at least 6 h, superior to those provided by CL-NPs containing small-molecule CL donors. When intravenously administered, the SIP-based CL-NPs clearly and precisely illuminate the ROS-abundant regions in four typical inflammatory disease models for hours. These findings suggest that SIP-based CL-NPs are potential contrast agents for in vivo ROS imaging and disease diagnosis.
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