Synthesis of 5,11-dialkyl-5,6,11,12-tetrahydro-6,12-epoxydibenzo[b,f][1,5]diazocines from 2-alkylaminobenzaldehydes

A simple methodology was developed for the synthesis of 5,11-dialkyl-5,6,11,12-tetrahydro-6,12-epoxydibenzo[b,f][1,5]diazocines by treatment of the respective 2-alkylaminobenzaldehydes with hydrogen chloride solution in dioxane at room temperature.

Automated summary

This methodology offers a straightforward approach to synthesize the targeted compound, which is achieved by reacting 2-alkylaminobenzaldehydes with hydrogen chloride solution in dioxane at room temperature.