Identification of potential repurposed drugs for treating endometriosis-associated infertility among women

Endometriosis is the most common gynecological abnormality seen in 10-15% of women of reproductive age, causing infertility in -25% of cases, which calls for treatment. Thus, in this study, we have identified miRNAs and genes involved in endometriosis progression, leading to infertility, by performing gene expression analysis followed by pathway analysis and protein-protein networks study. Further, we have predicted repurposed small molecule drugs that will neutralize the regulatory effect of targeting miRNAs that induce sterility in endometriosis. This study predicted two transcription factors, FOXO1, and CREB1, targeted by miRNAs that can be modulated by the repurposed drugs, BRD-K55473186, and methylstat, respectively, for the treatment of infertility due to endometriosis. The former drug seems better and more effective than the other as it showed stronger binding at the active site of FOXO1. These findings provide the rationale for targeting miRNA-regulated transcriptional regulators controlling several biological processes to treat endometriosis and prevent the recurrence of implantation failure or infertility.

Automated summary

This study identified miRNAs and genes involved in endometriosis progression and infertility, and predicted repurposed drugs to counteract the regulatory effect of these miRNAs. One of the drugs showed promising results for treating infertility. These findings provide a theoretical basis for treating endometriosis and preventing recurrent infertility.