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JOURNAL OF ORGANIC CHEMISTRY (2014)
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JOURNAL OF ORGANIC CHEMISTRY (2014)
Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network
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Mechanism of Alcohol Oxidation Mediated by Copper(II) and Nitroxyl Radicals
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A DNA-Mediated Homogeneous Binding Assay for Proteins and Small Molecules
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Identification of Ligand-Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates
Lynn M. McGregor et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
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NATURE (2014)
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NATURE (2014)
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NATURE CHEMISTRY (2014)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
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SYNLETT (2014)
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TALANTA (2014)
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ACS CHEMICAL BIOLOGY (2013)
Photoaffinity Labeling of Small-Molecule-Binding Proteins by DNA-Templated Chemistry
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
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CURRENT OPINION IN STRUCTURAL BIOLOGY (2013)
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Robin Hertzberg et al.
JOURNAL OF ORGANIC CHEMISTRY (2013)
Calculation of Vibrational Shifts of Nitrile Probes in the Active Site of Ketosteroid Isomerase upon Ligand Binding
Joshua P. Layfield et al.
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Tejas P. Pathak et al.
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Ashley B. Daugherty et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Multistep DNA-Templated Synthesis Using a Universal Template
Yizhou Li et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
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Sunkyu Han et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
A Chiral Sulfoxide-Ligated Ruthenium Complex for Asymmetric Catalysis: Enantio- and Regioselective Allylic Substitution
Barry M. Trost et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
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Jian Zhu et al.
NATURE BIOTECHNOLOGY (2013)
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Nicholas J. Turner et al.
NATURE CHEMICAL BIOLOGY (2013)
Label-assisted mass spectrometry for the acceleration of reaction discovery and optimization
Jaime R. Cabrera-Pardo et al.
NATURE CHEMISTRY (2013)
Cationic Pd(II)-Catalyzed Reductive Cyclization of Alkyne-Tethered Ketones or Aldehydes Using Ethanol as Hydrogen Source
Kun Shen et al.
ORGANIC LETTERS (2013)
Iridium-Catalyzed Cycloaddition of Azides and 1-Bromoalkynes at Room Temperature
Evelia Rasolofonjatovo et al.
ORGANIC LETTERS (2013)
Preparation of 1,5-Disubstituted 1,2,3-Triazoles via Ruthenium-catalyzed Azide Alkyne Cycloaddition
James S. Oakdale et al.
ORGANIC SYNTHESES (2013)
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Patricia L. Podolin et al.
PROSTAGLANDINS & OTHER LIPID MEDIATORS (2013)
Strategies for Stabilization of Enzymes in Organic Solvents
Veronika Stepankova et al.
ACS CATALYSIS (2013)
Simple and Highly Enantioselective Electrochemical Aptamer-Based Binding Assay for Trace Detection of Chiral Compounds
Lylian Challier et al.
ANALYTICAL CHEMISTRY (2012)
Protein Detection Based on Small Molecule-Linked DNA
Ya Cao et al.
ANALYTICAL CHEMISTRY (2012)
Reaction Discovery by Using a Sandwich Immunoassay
Julia Quinton et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Structure Formation and Catalytic Activity of DNA Dissolved in Organic Solvents
Hiroshi Abe et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Enantioselective Synthesis of Tertiary and Quaternary Stereogenic Centers: Copper/Phosphoramidite-Catalyzed Allylic Alkylation with Organolithium Reagents
Martin Fananas-Mastral et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Fragment-Based Approaches in Drug Discovery and Chemical Biology
Duncan E. Scott et al.
BIOCHEMISTRY (2012)
Detection of bond formations by DNA-programmed chemical reactions and PCR amplification
Yizhou Li et al.
CHEMICAL COMMUNICATIONS (2012)
Transition metal catalyzed nucleophilic allylic substitution: activation of allylic alcohols via pi-allylic species
Basker Sundararaju et al.
CHEMICAL SOCIETY REVIEWS (2012)
Rapid determination of enantiomeric excess: a focus on optical approaches
Diana Leung et al.
CHEMICAL SOCIETY REVIEWS (2012)
A General Synthesis of Alkenyl-Substituted Benzofurans, Indoles, and Isoquinolones by Cascade Palladium-Catalyzed Heterocyclization/Oxidative Heck Coupling (vol 16, pg 12746, 2010)
Rosana Alvarez et al.
CHEMISTRY-A EUROPEAN JOURNAL (2012)
Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library
Markus Leimbacher et al.
CHEMISTRY-A EUROPEAN JOURNAL (2012)
Determination of acetylcholinesterase activity by the Ellman assay: A versatile tool for in vitro research on medical countermeasures against organophosphate poisoning
Franz Worek et al.
DRUG TESTING AND ANALYSIS (2012)
Synthesis of Tetrahydrodibenzofuran and Tetrahydrophenanthridinone Skeletons by Intramolecular Nucleopalladation/Oxidative Heck Cascades
Claudio Martinez et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2012)
Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)
Hongfeng Deng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Synthesis of (+)-Ambrisentan via Chiral Ketone-Catalyzed Asymmetric Epoxidation
Xianyou Peng et al.
JOURNAL OF ORGANIC CHEMISTRY (2012)
Z-Selective Copper-Catalyzed Asymmetric Allylic Alkylation with Grignard Reagents
Massimo Giannerini et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Fluorophore Targeting to Cellular Proteins via Enzyme-Mediated Azide Ligation and Strain-Promoted Cycloaddition
Jennifer Z. Yao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Origins of Enantioselectivity during Allylic Substitution Reactions Catalyzed by Metallacyclic Iridium Complexes
Sherzod T. Madrahimov et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Catalytic Site-Selective Thiocarbonylations and Deoxygenations of Vancomycin Reveal Hydroxyl-Dependent Conformational Effects
Brandon S. Fowler et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Engineering the third wave of biocatalysis
U. T. Bornscheuer et al.
NATURE (2012)
Three-component reaction discovery enabled by mass spectrometry of self-assembled monolayers
Timothy J. Montavon et al.
NATURE CHEMISTRY (2012)
Halocarbocyclization Entry into the Oxabicyclo[4.3.1]decyl Exomethylene-δ-Lactone Cores of Linearifolin and Zaluzanin A: Exploiting Combinatorial Catalysis
Sandeep K. Ginotra et al.
ORGANIC LETTERS (2012)
Enantioselective Rhodium-Catalyzed Synthesis of α-Chloromethylene-γ-Butyrolactams from N-Allylic Alkynamides
Olivier Jackowski et al.
ORGANIC LETTERS (2012)
Highly Parallel Translation of DNA Sequences into Small Molecules
Rebecca M. Weisinger et al.
PLOS ONE (2012)
Profiling Cellular Protein Complexes by Proximity Ligation with Dual Tag Microarray Readout
Maria Hammond et al.
PLOS ONE (2012)
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Robin Hertzberg et al.
TETRAHEDRON (2012)
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Vishnumaya Bisai et al.
TETRAHEDRON (2012)
Infrared Thermography as a High-Throughput Tool in Catalysis Research
Jonas Loskyll et al.
ACS COMBINATORIAL SCIENCE (2012)
Optimization of the structure-switching aptamer-based fluorescence polarization assay for the sensitive tyrosinamide sensing
Zhenyu Zhu et al.
ANALYTICA CHIMICA ACTA (2011)
Fluorescence polarization biosensor based on an aptamer enzymatic cleavage protection strategy
Anthony Kidd et al.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2011)
Terminal Protection of Small Molecule-Linked DNA: A Versatile Biosensor Platform for Protein Binding and Gene Typing Assay
Zhan Wu et al.
ANALYTICAL CHEMISTRY (2011)
Combinatorial Catalysis Employing a Visible Enzymatic Beacon in Real Time: Synthetically Versatile (Pseudo)Halometalation/Carbocyclizations
Jacob A. Friest et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
A Colorimetric High-Throughput Screening Method for Palladium-Catalyzed Coupling Reactions of Aryl Iodides Using a Gold Nanoparticle-Based Iodide-Selective Probe
Eunhye Jung et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Electrostatic Fields near the Active Site of Human Aldose Reductase: 2. New Inhibitors and Complications Caused by Hydrogen Bonds
Lin Xu et al.
BIOCHEMISTRY (2011)
A new dehydrogenase from Clostridium acetobutylicum for asymmetric synthesis: dynamic reductive kinetic resolution entry into the Taxotere side chain
Gregory A. Applegate et al.
CHEMICAL COMMUNICATIONS (2011)
Small-molecule discovery from DNA-encoded chemical libraries
Ralph E. Kleiner et al.
CHEMICAL SOCIETY REVIEWS (2011)
Perspectives on Sesquiterpene Lactones in Inflammation and Cancer
Irmgard Merfort
CURRENT DRUG TARGETS (2011)
Status of protein engineering for biocatalysts: how to design an industrially useful biocatalyst
Andreas S. Bommarius et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2011)
Celecoxib A Review of its Use for Symptomatic Relief in the Treatment of Osteoarthritis, Rheumatoid Arthritis and Ankylosing Spondylitis
Paul L. McCormack
DRUGS (2011)
Opposite Enantiomers from Minor Enantiomer Recycling and Dynamic Kinetic Resolution Using a Single Biocatalyst
Anna Laurell et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2011)
Palladium(II)-Catalyzed Synthesis of Functionalized Indenes from o-Alkynylbenzylidene Ketones
Feng Zhou et al.
JOURNAL OF ORGANIC CHEMISTRY (2011)
Exploiting the Facile Release of Trifluoroacetate for the α-Methylenation of the Sterically Hindered Carbonyl Groups on (+)-Sclareolide and (-)-Eburnamonine
Mark V. Riofski et al.
JOURNAL OF ORGANIC CHEMISTRY (2011)
A Sequential Strand-Displacement Strategy Enables Efficient Six-Step DNA-Templated Synthesis
Yu He et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Determining the Enantioselectivity of Chiral Catalysts by Mass Spectrometric Screening of Their Racemic Forms
Christian Ebner et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
A biomolecule-compatible visible-light-induced azide reduction from a DNA-encoded reaction-discovery system
Yiyun Chen et al.
NATURE CHEMISTRY (2011)
Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood
Martin Lundberg et al.
NUCLEIC ACIDS RESEARCH (2011)
Hybrid bidentate phosphorus ligands in asymmetric catalysis: Privileged ligand approach vs. combinatorial strategies
Jeroen Wassenaar et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2011)
ProteinSeq: High-Performance Proteomic Analyses by Proximity Ligation and Next Generation Sequencing
Spyros Darmanis et al.
PLOS ONE (2011)
Discovery of an α-Amino C-H Arylation Reaction Using the Strategy of Accelerated Serendipity
Andrew McNally et al.
SCIENCE (2011)
A Simple, Multidimensional Approach to High-Throughput Discovery of Catalytic Reactions
Daniel W. Robbins et al.
SCIENCE (2011)
Mechanistic studies on the enantioselective BINOLAM/titanium(IV)-catalyzed cyanobenzoylation of aldehydes: Part 1
Alejandro Baeza et al.
TETRAHEDRON-ASYMMETRY (2011)
Evaluation of small ligand-protein interactions by using T7 RNA polymerase with DNA-modified ligand
Masayasu Mie et al.
ANALYTICAL BIOCHEMISTRY (2010)
Phosphoramidites: Privileged Ligands in Asymmetric Catalysis
Johannes F. Teichert et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical libraries
Fabian Buller et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Profiling protein expression and interactions: proximity ligation as a tool for personalized medicine
A. Blokzijl et al.
JOURNAL OF INTERNAL MEDICINE (2010)
The Effects of α-Helical Structure and Cyanylated Cysteine on Each Other
Lena Edelstein et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2010)
Cyanylated Cysteine: A Covalently Attached Vibrational Probe of Protein-Lipid Contacts
Heather A. McMahon et al.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2010)
Helical Chiral 2-Aminopyridinium Ions: A New Class of Hydrogen Bond Donor Catalysts
Norito Takenaka et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Use of a Robust Dehydrogenase from an Archael Hyperthermophile in Asymmetric Catalysis-Dynamic Reductive Kinetic Resolution Entry into (S)-Profens
Jacob A. Friest et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Interaction-Dependent PCR: Identification of Ligand-Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment
Lynn M. McGregor et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Cell culture processes for monoclonal antibody production
Feng Li et al.
MABS (2010)
Autonomous multistep organic synthesis in a single isothermal solution mediated by a DNA walker
Yu He et al.
NATURE NANOTECHNOLOGY (2010)
Rhodium-Catalyzed Activation of C(sp3)-X (X = Cl, Br) Bond: An Intermolecular Halogen Exchange Case
Jianping Wang et al.
ORGANIC LETTERS (2010)
Synthesis of All-Carbon, Quaternary Center-Containing Cyclohexenones through an Organocatalyzed, Multicomponent Coupling
Hua Yang et al.
ORGANIC LETTERS (2010)
BIOCHEMISTRY Reengineering Enzymes
Stefan Lutz
SCIENCE (2010)
Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination
Jeffrey L. Gustafson et al.
SCIENCE (2010)
Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
Christopher K. Savile et al.
SCIENCE (2010)
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Warren R. J. D. Galloway et al.
NATURE COMMUNICATIONS (2010)
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
Ellen M. Sletten et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Mass spectrometric screening of chiral catalysts and catalyst mixtures
Constanze Annelie Mueller et al.
CHEMICAL COMMUNICATIONS (2009)
Discovery of TNF Inhibitors from a DNA-Encoded Chemical Library based on Diels-Alder Cycloaddition
Fabian Buller et al.
CHEMISTRY & BIOLOGY (2009)
Minor Enantiomer Recycling: Metal Catalyst, Organocatalyst and Biocatalyst Working in Concert
Erica Wingstrand et al.
CHEMISTRY-A EUROPEAN JOURNAL (2009)
Chiral Lewis Base Catalyzed Enantioselective Acetylcyanation of α-Oxo Esters
Fei Li et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2009)
Asymmetric Epoxidation of Fluoroolefins by Chiral Dioxirane. Fluorine Effect on Enantioselectivity
O. Andrea Wong et al.
JOURNAL OF ORGANIC CHEMISTRY (2009)
Semisynthetic Derivatives of Sesquiterpene Lactones by Palladium-Catalyzed Arylation of the α-Methylene-γ-lactone Substructure
Changho Han et al.
JOURNAL OF ORGANIC CHEMISTRY (2009)
Reactivity-Dependent PCR: Direct, Solution-Phase in Vitro Selection for Bond Formation
David J. Gorin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Highly Efficient Asymmetric Synthesis of Sitagliptin
Karl B. Hansen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution
Margit Haahr Hansen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Terminal Protection of Small-Molecule-Linked DNA for Sensitive Electrochemical Detection of Protein Binding via Selective Carbon Nanotube Assembly
Zhan Wu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Shedding light on the efficacy of laboratory evolution based on iterative saturation mutagenesis
Manfred T. Reetz et al.
MOLECULAR BIOSYSTEMS (2009)
Design, synthesis and selection of DNA-encoded small-molecule libraries
Matthew A. Clark et al.
NATURE CHEMICAL BIOLOGY (2009)
Enantioselective sulfonylation reactions mediated by a tetrapeptide catalyst
Kristin Williams Fiori et al.
NATURE CHEMISTRY (2009)
Continuous base identification for single-molecule nanopore DNA sequencing
James Clarke et al.
NATURE NANOTECHNOLOGY (2009)
Enantioselective, Ketoreductase-Based Entry into Pharmaceutical Building Blocks: Ethanol as Tunable Nicotinamide Reductant
Sylvain Broussy et al.
ORGANIC LETTERS (2009)
Asymmetric Radical and Anionic Cyclizations of Axially Chiral Carbamates
David B. Guthrie et al.
ORGANIC LETTERS (2009)
Effect of the new pyrazole carboxamide fungicide penthiopyrad on late leaf spot and stem rot of peanut
Albert K. Culbreath et al.
PEST MANAGEMENT SCIENCE (2009)
A general protocol for creating high-throughput screening assays for reaction yield and enantiomeric excess applied to hydrobenzoin
Shagufta H. Shabbir et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
High-Throughput Affinity-Based Technologies for Small-Molecule Drug Discovery
Zhengrong Zhu et al.
JOURNAL OF BIOMOLECULAR SCREENING (2009)
Palladium-catalyzed oxidative cyclization of enynes with hydrogen peroxide as the oxidant
Guoyin Yin et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Mass spectrometric screening of chiral catalysts by monitoring the back reaction of quasienantionneric products: Palladium-catalyzed allylic substitution
Constanze A. Mueller et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
The telescoped intramolecular Michael/olefination (TIMO) approach to alpha-alkylidene-gamma-butyrolactones: Synthesis of (+)-paeonilactone B
Michael G. Edwards et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Metal-catalyzed enantioselective allylation in asymmetric synthesis
Zhan Lu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
DNA-encoded chemical libraries for the discovery of MMP-3 inhibitors
Joerg Scheuermann et al.
BIOCONJUGATE CHEMISTRY (2008)
Lewis Acid Catalyzed Asymmetric Cyanohydrin Synthesis
Michael North et al.
CHEMICAL REVIEWS (2008)
Use of proximity ligation to screen for inhibitors of interactions between vascular endothelial growth factor A and its receptors
Sigrun M. Gustafsdottir et al.
CLINICAL CHEMISTRY (2008)
Dissolution of biomacromolecules in organic solvents by nano-complexing with poly(ethylene glycol)
Hyejung Mok et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)
Translation of DNA into a Library of 13 000 Synthetic Small-Molecule Macrocycles Suitable for in Vitro Selection
Brian N. Tse et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Using enantioselective indicator displacement assays to determine the enantiomeric excess of α-amino acids
Diana Leung et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Ruthenium-catalyzed azide-alkyne cycloaddition: Scope and mechanism
Brant C. Boren et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs
Donglu Zhang et al.
DRUG METABOLISM AND DISPOSITION (2008)
Enantioselective cyanation of benzaldehyde: An asymmetric polymeric catalyst in a microreactor
Stina Lundgren et al.
ARKIVOC (2008)
Development and initial application of a hybridization-independent, DNA-encoded reaction discovery system compatible with organic solvents
Mary M. Rozenman et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Advances in the enzymatic reduction of ketones
Jeffrey C. Moore et al.
ACCOUNTS OF CHEMICAL RESEARCH (2007)
Synthetic ligands discovered by in vitro selection
S. Jarrett Wrenn et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Copper-free click chemistry for dynamic in vivo imaging
Jeremy M. Baskin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Do ligand binding and solvent exclusion alter the electrostatic character within the oxyanion hole of an enzymatic active site?
Paul A. Sigala et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Resting state and kinetic studies on the asymmetric allylic substitutions catalyzed by iridium-phosphoramidite complexes
Dean Markovic et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Organocatalytic enantioselective cascade Michael-alkylation reactions: Synthesis of chiral cyclopropanes and investigation of unexpected organocatalyzed stereoselective ring opening of cyclopropanes
Hexin Xie et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Aptazyme-based riboswitches as label-free and detector-free sensors for cofactors
Atsushi Ogawa et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Synthesis of cyclopropanes via Pd(II/IV)-catalyzed reactions of enynes
Leilani L. Welbes et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Multiplexed protein detection by proximity ligation for cancer biomarker validation
Simon Fredriksson et al.
NATURE METHODS (2007)
Discovery of chemical reactions through multidimensional screening
Aaron B. Beeler et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Lewis acid-Lewis base-catalysed enantioselective addition of α-ketonitriles to aldehydes
Stina Lundgren et al.
ADVANCED SYNTHESIS & CATALYSIS (2007)
Examination of the new α-(2′Z-Fluoro)vinyl trigger with lysine decarboxylase:: The absolute stereochemistry dictates the reaction course
Kannan R. Karukurichi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
High-throughput synthesis and analysis of acylated cyanohydrins
Anders Hamberg et al.
CHEMISTRY-A EUROPEAN JOURNAL (2007)
Isolation of high-affinity trypsin inhibitors from a DNA-encoded chemical library
Samu Melkko et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Enantioselective synthesis of arglabin
Srinivas Kalidindi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Cassette in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of Epoxides
Sangeeta Dey et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Applications of planar-chiral heterocycles as ligands in asymmetric catalysis
Gregory C. Fu
ACCOUNTS OF CHEMICAL RESEARCH (2006)
Pd(II)-catalyzed cascade Wacker-Heck reaction:: Chemoselective coupling of two electron-deficient reactants
Franck Silva et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Site-specific conversion of cysteine thiols into thiocyanate creates an IR probe for electric fields in proteins
Aaron T. Fafarman et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Predicting the stereochemistry of diphenylphosphino benzoic acid (DPPBA)-based palladium-catalyzed asymmetric allylic alkylation reactions: A working model
Barry M. Trost et al.
ACCOUNTS OF CHEMICAL RESEARCH (2006)
A red-fluorescent substrate microarray for lipase fingerprinting
Johann Grognux et al.
MOLECULAR BIOSYSTEMS (2006)
Development of a structural model for NF-κB inhibition of sesquiterpene lactones using self-organizing neural networks
S Wagner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
α-vinylic amino acids:: occurrence, asymmetric synthesis, and biochemical mechanisms
David B. Berkowitz et al.
TETRAHEDRON-ASYMMETRY (2006)
A formal [3,3]-sigmatropic rearrangement route to quaternary α-vinyl amino acids:: Use of allylic N-PMP trifluoroacetimidates
DB Berkowitz et al.
ORGANIC LETTERS (2006)
High-throughput enzymatic method for enantiomeric excess determination of O-acetylated cyanohydrins
A Hamberg et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
DNA-templated synthesis in organic solvents
MM Rozenman et al.
CHEMBIOCHEM (2006)
Low background FRET-substrates for lipases and esterases suitable for high-throughput screening under basic (pH 11) conditions
YZ Yang et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2006)
DBU catalyzed cyanoacylation of ketones with acyl cyanides
W Zhang et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2006)
Asymmetric organocatalytic conjugate addition of malonates to enones using a proline tetrazole catalyst
KR Knudsen et al.
CHEMICAL COMMUNICATIONS (2006)
Site-selective derivatization and remodeling of erythromycin A by using simple peptide-based chiral catalysts
Chad A. Lewis et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Protein structure similarity clustering: Dynamic treatment of PDB structures facilitates clustering
Bradley D. Charette et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Enantioselective catalysis and analysis on a chip
D Belder et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Regio- and enantioselective epoxidation of dienes by a chiral dioxirane: Synthesis of optically active vinyl cis-epoxides
Christopher P. Burke et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
New monofunctionalized fluorescein derivatives for the efficient high-throughput screening of lipases and esterases in aqueous media
YZ Yang et al.
HELVETICA CHIMICA ACTA (2006)
Using enzyme inhibition as a high throughput method to measure the enantiomeric excess of a chiral sulfoxide
CM Sprout et al.
ORGANIC LETTERS (2005)
Catalytic enantioselective synthesis of glutamic acid derivatives via tandem conjugate addition-elimination of activated allylic acetates under chiral PTC conditions
PV Ramachandran et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Chiral sensing using a blue fluorescent antibody
Hana Matsushita et al.
MOLECULAR BIOSYSTEMS (2005)
Accurate multiplex polony sequencing of an evolved bacterial genome
J Shendure et al.
SCIENCE (2005)
Dual Lewis acid-Lewis base activation in enantioselective cyanation of aldehydes using acetyl cyanide and cyanoformate as cyanide sources
S Lundgren et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Asymmetric Mannich reactions of β-keto esters with acyl imines catalyzed by cinchona alkaloids
S Lou et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
A strain-promoted [3+2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems (vol 126, pg 15046, 2004)
NJ Agard et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Asymmetric synthesis of O-benzoyl cyanohydrins by reaction of aldehydes with benzoyl cyanide catalysed by BINOLAM-Ti(IV) complexes
A Baeza et al.
TETRAHEDRON-ASYMMETRY (2005)
Diversity-oriented synthesis: exploring the intersections between chemistry and biology
DS Tan
NATURE CHEMICAL BIOLOGY (2005)
Double-cuvette ISES: In situ estimation of enantioselectivity and relative rate for catalyst screening
S Dey et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Colorimetric enantiodiscrimination of α-amino acids in protic media
JF Folmer-Andersen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
A fluorescence-based assay for Baeyer-Villiger monooxygenases, hydroxylases and lactonases
R Sicard et al.
ADVANCED SYNTHESIS & CATALYSIS (2005)
Protease profiling using a fluorescent domino peptide cocktail
YZ Yang et al.
MOLECULAR BIOSYSTEMS (2005)
Structure of ACC synthase inactivated by the mechanism-based inhibitor L-vinylglycine
G Capitani et al.
FEBS LETTERS (2005)
Guidelines in implementing enantioselective indicator-displacement assays for α-hydroxycarboxylates and diols
L Zhu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
DNA-templated functional group transformations enable sequence-programmed synthesis using small-molecule reagents
K Sakurai et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Sandwich immunoassay as a high-throughput screening method for cross-coupling reactions
P Vicennati et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Direct asymmetric alpha-fluorination of aldehydes
DD Steiner et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Expanding the range of substrate acceptance of enzymes: Combinatorial active-site saturation test
MT Reetz et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
The quest for quinine: Those who won the battles and those who won the war
TS Kaufman et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Asymmetric synthesis of selectively protected amino sugars and derivatives by a direct organocatalytic Mannich reaction
D Enders et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Zinc-metal promoted selective α-haloacylation and gem-bisacylation of alkyl aldehydes in the presence of chlorotrimethylsilane
Y Ishino et al.
TETRAHEDRON LETTERS (2004)
Facile quantification of enantiomeric excess and concentration with indicator-displacement assays:: An example in the analyses of α-hydroxyacids
L Zhu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
High-throughput measurement of the enantiomeric excess of chiral alcohols by using two enzymes
Z Li et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
Polarimetric assay for the medium-throughput determination of α-amino acid racemase activity
DL Schönfeld et al.
ANALYTICAL CHEMISTRY (2004)
Mechanistic investigation leads to a synthetic improvement in the hydrolytic kinetic resolution of terminal epoxides
LPC Nielsen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Nanoparticles from cationic copolymer and DNA that are soluble and stable in common organic solvents
M Ganguli et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Reaction discovery enabled by DNA-templated synthesis and in vitro selection
MW Kanan et al.
NATURE (2004)
In situ enzymatic screening (ISES) of P,N-ligands for Ni(0)-mediated asymmetric intramolecular allylic amination
DB Berkowitz et al.
TETRAHEDRON-ASYMMETRY (2004)
Asymmetric allylic alkylation, an enabling methodology
BM Trost
JOURNAL OF ORGANIC CHEMISTRY (2004)
Following an ISES lead: The first examples of asymmetric Ni(0)-mediated allylic amination
DB Berkowitz et al.
ORGANIC LETTERS (2004)
The enantioselective synthesis of α-amino acids by phase-transfer catalysis with achiral Schiff base esters
MJ O'Donnell
ACCOUNTS OF CHEMICAL RESEARCH (2004)
Asymmetric phase-transfer catalysis utilizing chiral quaternary ammonium salts: Asymmetric alkylation of glycine imines
B Lygo et al.
ACCOUNTS OF CHEMICAL RESEARCH (2004)
A strain-promoted [3+2] azide-alkyne cycloaddition for covalent modification of blomolecules in living systems
NJ Agard et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Rhodium-catalyzed cycloisomerization of 1,6-enynes with an intramolecular halogen shift: Reaction scope and mechanism
XF Tong et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Combinatorial approach to chiral catalyst engineering and screening: Rational design and serendipity
KL Ding et al.
CHEMISTRY-A EUROPEAN JOURNAL (2004)
A high-throughput NMR-based ee-assay using chemical shift imaging
MT Reetz et al.
CHEMICAL COMMUNICATIONS (2004)
Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes
P Wu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
Screening of chiral catalysts and catalyst mixtures by mass spectrometric monitoring of catalytic intermediates
C Markert et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
Catalytic promiscuity in biocatalysis: Using old enzymes to form new bonds and follow new pathways
UT Bornscheuer et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
A planning strategy for diversity-oriented synthesis
MD Burke et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
Three-component condensation leading to β-amino acid diamides:: Convergent assembly of β-peptide analogues
JM Oaksmith et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Combinatorial chemistry and high-throughput screening for the discovery of organocatalysts
MH Fonseca et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2004)
Synthesis of quaternary amino acids bearing a (2′Z)-fluorovinyl α-branch:: Potential PLP enzyme inactivators
DB Berkowitz et al.
ORGANIC LETTERS (2004)
Cinchona alkaloid-Lewis acid catalyst systems for enantioselective ketene-aldehyde cycloadditions
C Zhu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Encoded self-assembling chemical libraries
S Melkko et al.
NATURE BIOTECHNOLOGY (2004)
Identification of an activated catalyst in the iridium-catalyzed allylic amination and etherification. Increased rates, scope, and selectivity
CA Kiener et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Photoionization detection (PID) as a high throughput screening tool in catalysis
S Senkan et al.
APPLIED CATALYSIS A-GENERAL (2003)
Using a lipase as a high-throughput screening method for measuring the enantiomeric excess of allylic acetates
MB Onaran et al.
JOURNAL OF ORGANIC CHEMISTRY (2003)
The direct and enantioselective organocatalytic α-oxidation of aldehydes
SP Brown et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
A practical high-throughput screening system for enantioselectivity by using FTIR spectroscopy
P Tielmann et al.
CHEMISTRY-A EUROPEAN JOURNAL (2003)
Asymmetric transition-metal-catalyzed allylic alkylations: Applications in total synthesis
BM Trost et al.
CHEMICAL REVIEWS (2003)
Cyanobenzoylation and hydrocyanation of aldehydes with benzoyl cyanide using no catalyst
T Watahiki et al.
ORGANIC LETTERS (2003)
Fluorescence resonance energy transfer (FRET) as a high-throughput assay for coupling reactions. Arylation of amines as a case study
SR Stauffer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Recent advances in the discovery of organometallic catalysts using high-throughput screening assays
JP Stambuli et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2003)
Novel rhodium-catalyzed cycloisomerization of 1,6-enynes with an intramolecular halogen shift
XF Tong et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Facile asymmetric synthesis of the core nuclei of xanthanolides, guaianolides, and eudesmanolides
B Nosse et al.
ORGANIC LETTERS (2003)
Fluorophoric assay for the high-throughput determination of amidase activity
E Henke et al.
ANALYTICAL CHEMISTRY (2003)
High-throughput screening by using a blue-fluorescent antibody sensor
M Matsushita et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
A high-throughput-screening method for determining the synthetic activity of hydrolases
M Konarzycka-Bessler et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Regio- and enantiospecific rhodium-catalyzed allylic etherification reactions using copper(I) alkoxides: Influence of the copper halide salt on selectivity
PA Evans et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Protein detection using proximity-dependent DNA ligation assays
S Fredriksson et al.
NATURE BIOTECHNOLOGY (2002)
Highly selective hydrolytic kinetic resolution of terminal epoxides catalyzed by chiral (salen)CoIII complexes.: Practical synthesis of enantioenriched terminal epoxides and 1,2-diols
SE Schaus et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
In vitro selection of DNA aptamers that bind L-Tyrosinamide
E Vianini et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2001)
EMDee: An enzymatic method for determining enantiomeric excess
P Abato et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Role of halide ions in divalent palladium-mediated reactions:: Competition between β-heteroatom elimination and β-hydride elimination of a carbon-palladium bond
ZG Zhang et al.
ORGANOMETALLICS (2001)
Stereocontrolled synthesis of quaternary β,γ-unsaturated amino acids:: chain extension of D- and L-α-(2-tributylstannyl)vinyl amino acids
DB Berkowitz et al.
TETRAHEDRON (2001)
The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules
ZJ Gartner et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
A GC-based method for high-throughput screening of enantio selective catalysts
MT Reetz et al.
CATALYSIS TODAY (2001)
Transition metal-catalyzed addition of amines to acrylic acid derivatives. A high-throughput method for evaluating hydroamination of primary and secondary alkylamines
M Kawatsura et al.
ORGANOMETALLICS (2001)
New fluorogenic probes for oxygen and carbene transfer: A sensitive assay for single bead-supported catalysts
R Moreira et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Screening of homogeneous catalysts by fluorescence resonance energy transfer. Identification of catalysts for room-temperature Heck reactions
JP Stambuli et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Reaction microarrays: A method for rapidly determining the enantiomeric excess of thousands of samples
GA Korbel et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
Rapid screening and combinatorial methods in homogeneous organometallic catalysis
JA Loch et al.
PURE AND APPLIED CHEMISTRY (2001)
Organoselenium-based entry into versatile, α-(2-tributylstannyl)vinyl amino acids in scalemic form:: A new route to vinyl stannanes
DB Berkowitz et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Highly enantioselective palladium(II)-catalyzed cyclization of (Z)-4′-acetoxy-2′-butenyl 2-alkynoates:: An efficient synthesis of optically active γ-butyrolactones
QH Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Dynamic kinetic asymmetric transformation of diene monoepoxides: A practical asymmetric synthesis of vinylglycinol, vigabatrin, and ethambutol
BM Trost et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Enantioselective nucleophilic catalysis with planar-chiral heterocycles
GC Fu
ACCOUNTS OF CHEMICAL RESEARCH (2000)
Engineering acyclic stereocontrol in the alkylation of vinylglycine-derived dianions:: Asymmetric synthesis of higher α-vinyl amino acids
DB Berkowitz et al.
JOURNAL OF ORGANIC CHEMISTRY (2000)
Target-oriented and diversity-oriented organic synthesis in drug discovery
SL Schreiber
SCIENCE (2000)
Nickel(0)-catalyzed asymmetric cross-coupling reactions of allylic compounds with arylboronic acids
KG Chung et al.
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 (2000)
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