期刊
CELLULAR SIGNALLING
卷 95, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2022.110354
关键词
miR-141; cancer; Mechanisms; Signal pathways; Therapeutic; Diagnosis
类别
资金
- National Natural Science Foundation of China [8197020464]
miR-141, as a member of the miRNA family, plays a crucial role in cancer development and regulates various functions of cancer cells through different signaling pathways. It has been suggested that miR-141 may serve as a noninvasive biomarker and a therapeutic target in cancer.
Cancer is caused by the abnormal proliferation of local tissue cells under the control of many oncogenic factors. MicroRNAs (miRNAs) are a class of evolutionarily conserved, approximately 22-nucleotide noncoding small RNAs that influence transcriptional regulationby binding to the 3'-untranslated region of target messenger RNA. As a member of the miRNA family, miR-141 acts as a suppressor or an oncomiR in various cancers and regulates cancer cell proliferation, apoptosis, invasion, and metastasis through a variety of signaling pathways, such as phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) and constitutive activation of nuclear factor-kappa B (NF-kappa B). Target gene validation and pathway analysis have provided mechanistic insight into the role of this miRNA in different tissues. This review also outlines novel findings that suggest miR-141 may be useful as a noninvasive biomarker and as a therapeutic target in several cancers.
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