4.7 Review

The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Microbiology

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

H-Heinrich Hoffmann et al.

Summary: A study utilizing CRISPR-Cas9 technology targeted 332 members of the SARS-CoV-2 protein interactome, revealing new insights about coronaviruses and providing important references for future outbreaks.

CELL HOST & MICROBE (2021)

Article Biochemistry & Molecular Biology

Ultrastructural modifications induced by SARS-CoV-2 in Vero cells: a kinetic analysis of viral factory formation, viral particle morphogenesis and virion release

Sebastien Eymieux et al.

Summary: Studies on SARS-CoV-2 have shown that early infection events involve clusters of single-membrane vesicles and annulate lamellae, with host cell-derived organelles transforming into virus factories later on.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Immunology

The interplay between emerging human coronavirus infections and autophagy

Zhenyu Zhao et al.

Summary: SARS-CoV-2 is the third highly pathogenic emerging human coronavirus, causing the COVID-19 pandemic globally. Studies show that coronavirus infections may be related to autophagy, which could even promote viral infection and replication. It remains unclear how coronavirus infections induce autophagy and whether the autophagic machinery is essential for viral propagation.

EMERGING MICROBES & INFECTIONS (2021)

Article Biochemistry & Molecular Biology

Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

Ryan A. Flynn et al.

Summary: The study identified host proteins that bind to SARS-CoV-2 RNA and protect the host from virus-induced cell death. It also found a physical and functional connection between SARS-CoV-2 and mitochondria, highlighting the organelle as a general platform for antiviral activity.
Article Multidisciplinary Sciences

Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation

Keisuke Tabata et al.

Summary: Study shows that cellular acyltransferases AGPAT1/2 are crucial for DMV biogenesis of HCV and SARS-CoV-2, highlighting a potential common target for host-targeting therapy against these evolutionarily distinct positive-strand RNA viruses.

NATURE COMMUNICATIONS (2021)

Review Cell Biology

Annulate lamellae and intracellular pathogens

Sebastien Eymieux et al.

Summary: Annulate lamellae (AL) are organelles composed of stacked sheets of endoplasmic reticulum-derived membranes with nuclear pore complexes (NPCs), and they may play a role in viral infection and regulate Ca2+ homeostasis or cell cycle control. Further studies are needed to clarify their role in intracellular pathogen/host-cell interactions.

CELLULAR MICROBIOLOGY (2021)

Article Cell Biology

SARS-CoV-2 exploits host DGAT and ADRP for efficient replication

Shuofeng Yuan et al.

Summary: The study found that triglycerides in the plasma lipidome of COVID-19 patients are the dominant lipids in metabolic dysregulation, with the key enzymes DGAT and stabilizer ADRP being essential for virus replication. Depletion of DGAT gene reduces virus protein synthesis without affecting genome replication. An inhibitor called xanthohumol was able to suppress virus replication and pulmonary inflammation in a hamster model.

CELL DISCOVERY (2021)

Article Biochemistry & Molecular Biology

RNA-GPS Predicts SARS-CoV-2 RNA Residency to Host Mitochondria and Nucleolus

Kevin E. Wu et al.

CELL SYSTEMS (2020)

Review Biochemistry & Molecular Biology

The molecular virology of coronaviruses

Ella Hartenian et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

A molecular pore spans the double membrane of the coronavirus replication organelle

Georg Wolff et al.

SCIENCE (2020)

Review Biochemistry & Molecular Biology

Double-Membrane Vesicles as Platforms for Viral Replication

Georg Wolff et al.

TRENDS IN MICROBIOLOGY (2020)

Article Microbiology

Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies

Mirko Cortese et al.

CELL HOST & MICROBE (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography

Steffen Klein et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Physical

Double membrane formation in heterogeneous vesicles

Dima Bolmatov et al.

SOFT MATTER (2020)

Article Biochemistry & Molecular Biology

Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication

Orly Laufman et al.

Article Biotechnology & Applied Microbiology

Replicase-mediated shielding of the poliovirus replicative double-stranded RNA to avoid recognition by MDA5

Xiaoting Du et al.

JOURNAL OF GENERAL VIROLOGY (2018)

Review Cell Biology

Lipid droplet hijacking by intracellular pathogens

Philippe Roingeard et al.

CELLULAR MICROBIOLOGY (2017)

Review Cell Biology

Lipid Tales of Viral Replication and Transmission

Nihal Altan-Bonnett

TRENDS IN CELL BIOLOGY (2017)

Article Microbiology

Membrane alterations induced by nonstructural proteins of human norovirus

Sylvie Y. Doerflinger et al.

PLOS PATHOGENS (2017)

Article Virology

Biogenesis and architecture of arterivirus replication organelles

Barbara van der Hoeven et al.

VIRUS RESEARCH (2016)

Review Cell Biology

Virus-induced double-membrane vesicles

Emmanuelle Blanchard et al.

CELLULAR MICROBIOLOGY (2015)

Article Cell Biology

An autophagy-independent role for LC3 in equine arteritis virus replication

Iryna Monastyrska et al.

AUTOPHAGY (2013)

Article Biochemistry & Molecular Biology

Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection

Pauline Ferraris et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Article Biotechnology & Applied Microbiology

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

Adriaan H. de Wilde et al.

JOURNAL OF GENERAL VIROLOGY (2013)

Article Virology

Complex Dynamic Development of Poliovirus Membranous Replication Complexes

George A. Belov et al.

JOURNAL OF VIROLOGY (2012)

Article Biochemistry & Molecular Biology

Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein

Marion Depla et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

Article Biotechnology & Applied Microbiology

Ultrastructural and biochemical analyses of hepatitis C virus-associated host cell membranes

Pauline Ferraris et al.

JOURNAL OF GENERAL VIROLOGY (2010)

Article Cell Biology

The lipid droplet is an important organelle for hepatitis C virus production

Yusuke Miyanari et al.

NATURE CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Coronavirus replication complex formation utilizes components of cellular autophagy

E Prentice et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)