4.7 Review

SETD2: from chromatin modifier to multipronged regulator of the genome and beyond

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The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation

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The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II

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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins

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Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6

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The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly

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MOLECULAR CELL (2002)

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Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70

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