4.7 Article

METTL3 mediates Ang-II-induced cardiac hypertrophy through accelerating pri-miR-221/222 maturation in an m6A-dependent manner

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

ALKBH5 promotes lung fibroblast activation and silica-induced pulmonary fibrosis through miR-320a-3p and FOXM1

Wenqing Sun et al.

Summary: The study finds that ALKBH5 promotes silica-induced lung fibrosis through the miR-320a-3p/FOXM1 axis or direct targeting of FOXM1. Inhibition of ALKBH5 may be effective in treating lung fibrosis.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

Article Cell Biology

LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway

Mi Tian et al.

Summary: LKB1IP plays a crucial role in stress-induced cardiac hypertrophy, with its deficiency protecting the heart against hypertrophy and fibrosis. LKB1IP affects cardiac hypertrophy development by activating the Akt signaling pathway.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Cardiac & Cardiovascular Systems

Remodeling of the m6A landscape in the heart reveals few conserved post-transcriptional events underlying cardiomyocyte hypertrophy

Scott A. Hinger et al.

Summary: The study found an increased m(6)A content in human heart failure samples, with m(6)A-regulated sites enriched in targeted transcripts involved in histone modification in heart failure patients. Additionally, shared transcripts targeted by m(6)A under stress conditions and unique m(6)A events in unstressed cardiomyocytes were identified, indicating the potential impact of m(6)A on post-transcriptional regulation of gene expression in the heart.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2021)

Review Biochemistry & Molecular Biology

Molecular interactions of miR-338 during tumor progression and metastasis

Meysam Moghbeli

Summary: miR-338 functions as a tumor suppressor in different cancers and is significantly associated with other ncRNAs in tumor cells. It plays a crucial role in tumor progression by regulating various signaling pathways. This review highlights miR-338 as a pivotal ncRNA in the biology of tumor cells.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2021)

Article Cell Biology

METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner

Kun Zhao et al.

Summary: The study showed that METTL3 could enhance cardiomyocyte proliferation and inhibit apoptosis, potentially playing a role in alleviating myocardial infarction.

CELL DEATH DISCOVERY (2021)

Article Oncology

De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy

Peng Lu et al.

Summary: The study reveals that the deubiquitinating enzyme USP12 promotes cardiac hypertrophy by enhancing METTL3, suggesting that targeting USP12 could be a potential treatment strategy for pathological cardiac hypertrophy.

EXPERIMENTAL CELL RESEARCH (2021)

Review Biochemistry & Molecular Biology

A comprehensive review of m6A/m6Am RNA methyltransferase structures

Stephanie Oerum et al.

Summary: Gene expression is regulated through various levels, including chemical modifications on RNA during or after transcription. One such modification is N6-methylation, which affects the structure, stability, degradation, and cellular interactions of the modified RNA, with dysregulation linked to multiple human cancers.RNA methyltransferases are the enzymes responsible for these modifications, and structural characterization of these enzymes is critical for understanding their functions.

NUCLEIC ACIDS RESEARCH (2021)

Article Pharmacology & Pharmacy

Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury

Rui Gong et al.

Summary: Deficiency of METTL3 promotes cardiomyocyte proliferation and improves cardiac function after myocardial infarction by regulating the miR-143-Yap/Ctnnd1 axis. This study highlights the significance of RNA m(6)A modification in heart regeneration.

PHARMACOLOGICAL RESEARCH (2021)

Article Medicine, Research & Experimental

ALKBH5 regulates cardiomyocyte proliferation and heart regeneration by demethylating the mRNA of YTHDF1

Zhenbo Han et al.

Summary: The study reveals the significant role of m(6)A RNA modification in heart regeneration, with the ALKBH5-m(6)A-YTHDF1-YAP axis regulating cardiomyocytes to re-enter the cell cycle. This finding offers a novel therapeutic strategy for cardiac regeneration.

THERANOSTICS (2021)

Article Cardiac & Cardiovascular Systems

Sialyltransferase7A promotes angiotensin II-induced cardiomyocyte hypertrophy via HIF-1 alpha-TAK1 signalling pathway

Xiaoying Yan et al.

CARDIOVASCULAR RESEARCH (2020)

Article Biochemistry & Molecular Biology

miR-221 and-222 target CACNA1C and KCNJ5 leading to altered cardiac ion channel expression and current density

Stephanie Binas et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Review Cardiac & Cardiovascular Systems

Left ventricular hypertrophy and hypertension

Mehmet Yildiz et al.

PROGRESS IN CARDIOVASCULAR DISEASES (2020)

Review Cardiac & Cardiovascular Systems

Coronary microvascular dysfunction in hypertrophy and heart failure

Paolo G. Camici et al.

CARDIOVASCULAR RESEARCH (2020)

Article Medicine, Research & Experimental

METTL3 Induces AAA Development and Progression by Modulating N6-Methyladenosine-Dependent Primary miR34a Processing

Lintao Zhong et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Review Oncology

Targeting the Wnt/β-catenin signaling pathway in cancer

Ya Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Cell Biology

The role of m6A modification in physiology and disease

Chuan Yang et al.

CELL DEATH & DISEASE (2020)

Review Biochemistry & Molecular Biology

Function and evolution of RNA N6-methyladenosine modification

Zhi-Man Zhu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Review Cardiac & Cardiovascular Systems

Translating Translation to Mechanisms of Cardiac Hypertrophy

Michael J. Zeitz et al.

JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE (2020)

Article Cardiac & Cardiovascular Systems

FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair

Prabhu Mathiyalagan et al.

CIRCULATION (2019)

Review Biochemistry & Molecular Biology

Next-generation AAV vectors-do not judge a virus (only) by its cover

Claire Domenger et al.

HUMAN MOLECULAR GENETICS (2019)

Article Cardiac & Cardiovascular Systems

The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

Lisa E. Dorn et al.

CIRCULATION (2019)

Review Biochemistry & Molecular Biology

Functions of N6-methyladenosine and its role in cancer

Liuer He et al.

MOLECULAR CANCER (2019)

Article Biology

m6A-mRNA methylation regulates cardiac gene expression and cellular growth

Vivien Kmietczyk et al.

LIFE SCIENCE ALLIANCE (2019)

Review Cell Biology

N6-methyladenosine links RNA metabolism to cancer progression

Dongjun Dai et al.

CELL DEATH & DISEASE (2018)

Review Cardiac & Cardiovascular Systems

Noncoding RNAs in Cardiac Hypertrophy

Yongqin Li et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2018)

Review Endocrinology & Metabolism

The role of autophagy in angiotensin II-induced pathological cardiac hypertrophy

Lichun Zhou et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2016)

Review Biochemistry & Molecular Biology

Recent advances in dynamic m6A RNA modification

Guangchao Cao et al.

OPEN BIOLOGY (2016)

Article Multidisciplinary Sciences

N6-methyladenosine marks primary microRNAs for processing

Claudio R. Alarcon et al.

NATURE (2015)

Article Biochemical Research Methods

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

Edward Y. Chen et al.

BMC BIOINFORMATICS (2013)

Article Biochemistry & Molecular Biology

MiR-221 promotes cardiac hypertrophy in vitro through the modulation of p27 expression

Changxin Wang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2012)

Article Anesthesiology

The Clinical Implications of Isolated Alpha1 Adrenergic Stimulation

Robert H. Thiele et al.

ANESTHESIA AND ANALGESIA (2011)

Review Cell Biology

Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system

Puja K. Mehta et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)