期刊
CELL STEM CELL
卷 29, 期 7, 页码 1018-1030出版社
CELL PRESS
DOI: 10.1016/j.stem.2022.06.003
关键词
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资金
- MRC project grant [MR/N009371/1, MR/T028637/1]
- BBSRC [BB/S008284/1]
Mammalian embryos have remarkable plasticity, capable of correcting aberrant cells, adjusting growth, and integrating cells from different species to ensure normal development.
The mammalian embryo exhibits a remarkable plasticity that allows it to correct for the presence of aberrant cells, adjust its growth so that its size is in accordance with its developmental stage, or integrate cells of another species to form fully functional organs. Here, we will discuss the contribution that cell competition, a quality control that eliminates viable cells that are less fit than their neighbors, makes to this plasticity. We will do this by reviewing the roles that cell competition plays in the early mammalian embryo and how they contribute to ensure normal development of the embryo.
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