Holding back: HLA-associated inhibition of NK cells gives HIV a leg up

In this issue of Cell Host & Microbe, Li et al. unveil an association between HLA-B*46:01 and HIV disease progression in Asian populations. The distinct natural killer (NK) cell signature identified in individuals carrying HLA-B*46:01 strongly suggests that NK cell inhibition plays a role in loss of HIV control.

Automated summary

In this study, Li et al. reveal an association between HLA-B*46:01 and HIV disease progression in Asian populations, suggesting that NK cell inhibition plays a role in the loss of HIV control.