Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified as a distinct phe-nomenon and named a decade ago. Ferroptosis has been implicated in a broad set of biological contexts, from development to aging, immunity, and cancer. This review describes key regulators of this form of cell death within a framework of metabolism, ROS biology, and iron biology. Key concepts and major unan-swered questions in the ferroptosis field are highlighted. The next decade promises to yield further break-throughs in the mechanisms governing ferroptosis and additional ways of harnessing ferroptosis for therapeutic benefit.

Automated summary

This review describes the key regulators of ferroptosis and provides an overview of metabolism, ROS biology, and iron biology. Additionally, it highlights the important concepts and unanswered questions in the field of ferroptosis. The future holds promise for further breakthroughs in understanding the mechanisms of ferroptosis and utilizing it for therapeutic purposes.