期刊
CARBOHYDRATE POLYMERS
卷 290, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119501
关键词
Chitosan Schiff base; Antibacterial; Antioxidant; Cytotoxicity; THP-1 cells
资金
- Interdisciplinary Institute of Indian System of Medicine
- SRM institute of Technology
The imine derivatives of chitosan synthesized in this study showed strong antimicrobial and antioxidant activities, with no cytotoxic effects on host cells.
Two imine derivatives of chitosan (i-CTs), namely 2FCT and 5MCT, were synthesized by reacting chitosan (CT) with 2-(3-formyl-1H-indol-1yl)acetonitrile (2F), and 5-methoxyindole-3-carbaldehyde (5M), respectively. The antimicrobial evaluation of i-CTs exhibited stronger inhibition effect against Staphylococcus aureus , Escherichia coli and Candida albicans. The antioxidant activity of 2FCT and 5MCT showed strong scavenging ability with IC50 2.31 and 6.92 mu g/mL, respectively. The results of in vitro cytotoxicity of 2FCT and 5MCT examined using human monocyte leukemia (THP-1) cells indicate no cytotoxic effect on host cells and the value of cell viability was found to be 87.08 and 84.47%, respectively. Measurement of intracellular Reactive Oxygen Species (ROS) production by flow cytometry analysis revealed that the 2FCT and 5MCT reduced the ROS generation by 83 and 43%, respectively. In summary, these findings show that i-CTs synthesized to be promising biomaterial for biomedical applications such as wound healing.
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