期刊
CARBOHYDRATE POLYMERS
卷 289, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119440
关键词
Alginate; Polycaprolactone; Composite electrospun fibers; Wound dressing; Nano-silver; Platelet-derived growth factor-B
资金
- Ministry of Science and Technology of Taiwan [MOST 107-2221-E-008-044-from]
A composite wound dressing was developed for multifunctional wound care, combining alginate and PCL fibers, silver nanoparticles for antimicrobial properties, and PDGF-B gene delivery for accelerated wound healing. The study demonstrated enhanced wound closure and collagen formation with the use of these composite fibers.
We developed a composite wound dressing that provides multifunctional wound care. Alginate and polycaprolactone (PCL) were coelectrospun as composite fibers. Highly absorbent alginate provided a moist environment for wounds and PCL increased cell adhesion. Silver nanoparticles embedded in PCL fibers for long-term release inhibited the growth of microorganisms. In addition, plasmid DNA encoding platelet-derived growth factor-B (PDGF-B) were complexed with polyethylenimine (PEI) to form cationic nanoparticles which were then adsorbed on anionic alginate fibers through electrostatic interaction. As wound cells adhered to composite fibers, they were in situ transfected to express PDGF-B continuously. Moreover, calcium ions in alginate fibers were released into the wound site through ion exchange to accelerate hemostasis. Wound healing experiments demonstrated that PDGF-B gene-loaded composite fibers accelerated wound closure and promoted collagen formation. We expect this comprehensive study offers an ideal multifunctional solution to facilitate wound healing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据