期刊
CARBOHYDRATE POLYMERS
卷 287, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.119304
关键词
Polycystic ovary syndrome; Acylated starch; Short-chain fatty acid; Gut microbiota; Gut hormone
资金
- National Natural Science Foundation of China [31972052, 32021005, 31820103010]
- Fundamental Research Funds for the Central Universities [JUSRP22006, JUSRP51501]
- Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province
Butylated starch treatment can alleviate abnormal ovarian morphology, metabolic disorders, and sex hormone imbalance in PCOS. This effect may be mediated by the activation of GPR41 and the enrichment of butyrate-producing microbes in fecal microbiota.
Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects women of reproductive age. Resistant starch can be fermented by gut microbes then produce short-chain fatty acids (SCFAs). It was reported SCFAs might play a key role in gut microbiota-dependent therapy of PCOS. However, the effects of resistant starch on PCOS symptoms have not yet been investigated. Here, maize starch was acylated with specific SCFAs. Our results indicated that acylated starch can release acetate, propionate, and butyrate into the caecum and colon. Treatment with butylated starch (BS) alleviated abnormal ovarian morphology, metabolic disorders, and sex hormone imbalance in letrozole-treated rats, whereas treatment with acetylated starch and propylated starch did not exhibit such effects. Furthermore, BS stimulated the secretion of peptide tyrosine-tyrosine into the serum by activating a G protein-coupled receptor, GPR41, which further affected disease phenotypes. In addition, compared with caecal microbiota, faecal microbiota was more affected by BS. Butyrate-producing microbes were enriched in faeces after BS treatment and may have helped further to relieve PCOS symptoms.
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