期刊
CANCER LETTERS
卷 548, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2022.215823
关键词
Exosomes; Tumor microenvironment; Antitumor immunity; Immunotherapy
类别
资金
- National Natural Science Foundation of China [81871983/82003040]
- Natural Science Foundation of Liaoning Province [2020-BS-103]
- Scientific Research Funding of Liaoning Province Education Department [LJKZ0768/LJKZ0770]
- China Postdoctoral Science Foundation [2021M703602]
- Xingliaoyingcaijihua Project of Liaoning Province [XLYC1902050]
- Qingnianyingcaijihua Project of China Medical University
Tumor-derived exosomes (TDEs) play a critical role in regulating the immune microenvironment of tumors and have the ability to suppress immune responses, thus impacting the effectiveness of cancer therapy. By delivering suppressive factors to immune cells, TDEs directly or indirectly influence immune cell function and antitumor activities. TDE-based therapy is emerging as a promising strategy for inhibiting tumor progression and enhancing antitumor immunity.
Tumor-derived exosomes (TDEs) are key immune regulators in the tumor microenvironment. They have been shown to reshape the immune microenvironment and prevent antitumor immune responses via their immuno-suppressive cargo, thereby determining responsiveness to cancer therapy. By delivering suppressive cargo to the immune cells, TDEs directly or indirectly influence the functions and antitumor activities of immune cells. TDE-based therapy is emerging as a cutting-edge and promising strategy for inhibiting tumor progression or enhancing antitumor immunity. Therefore, in this study, we reviewed the mechanism by which TDEs regulate immune cells and their applications in immunotherapy.
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