期刊
CANCER LETTERS
卷 547, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2022.215870
关键词
RB1; Mutation; Retinoblastoma; Tumorigenesis
类别
资金
- Science and Technology Commission of Shanghai [20DZ2270800, 19JC1410200]
- Shanghai Jiaotong University School of Medicine [SHSMU-ZDCX20210902]
This review focuses on the mechanism underlying RB1 mutation during oncogenesis, as well as potential clinical strategies for treating RB1-mutated cancers. The unsolved problems and prospects of RB1 mutation are also discussed.
Since the discovery of the retinoblastoma susceptibility gene (RB1) decades ago, RB1 has been regarded as a prototype tumor suppressor gene providing a paradigm for tumor genetic research. Constant research has updated the understanding of RB1-related pathways and their impact on tumor and nontumor diseases. Mutation of RB1 gene has been observed in multiple types of malignant tumors including prostate cancer, lung cancer, breast cancer, and almost every familial and sporadic case of retinoblastoma. Even if well-known and long -investigated, the application potential of RB1 mutation has not been fully tapped. In this review, we focus on the mechanism underlying RB1 mutation during oncogenesis. Therapeutically, we have further discussed po-tential clinical strategies by targeting RB1-mutated cancers. The unsolved problems and prospects of RB1 mu-tation are also discussed.
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