4.5 Review

The adipocyte microenvironment and cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, General & Internal

Effect of Metformin vs Placebo on Invasive Disease-Free Survival in Patients With Breast Cancer The MA.32 Randomized Clinical Trial

Pamela J. Goodwin et al.

Summary: This study aimed to determine whether adjuvant metformin improves outcomes in breast cancer patients without diabetes. The results suggest that the addition of metformin to standard treatment did not significantly improve invasive disease-free survival in high-risk operable breast cancer patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

Article Cell Biology

Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

Olivia A. Maguire et al.

Summary: The study identified the key role of crosstalk between mammary adipocytes and neoplastic cells in promoting obesity-driven breast cancer progression. Glycine amidinotransferase (Gatm) in adipocytes and Acsbg1 in cancer cells were found to be crucial for this process.

CELL METABOLISM (2021)

Article Cell Biology

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

Xingzhe Ma et al.

Summary: Understanding the mechanisms of how T cells become dysfunctional in a tumor microenvironment is crucial for cancer immunotherapy. This study found that CD36 expression in tumor-infiltrating CD8(+) T cells, induced by TME cholesterol, is associated with tumor progression and poor survival, and that genetic ablation of Cd36 in these T cells leads to enhanced tumor eradication. Targeting CD36 or inhibiting ferroptosis could restore T cell function and enhance antitumor efficacy, especially in combination with anti-PD-1 antibodies.

CELL METABOLISM (2021)

Article Multidisciplinary Sciences

Dietary palmitic acid promotes a prometastatic memory via Schwann cells

Gloria Pascual et al.

Summary: The study suggests that dietary palmitic acid (PA), but not oleic acid or linoleic acid, may promote metastasis in oral carcinomas and melanoma in mice. The PA-induced prometastatic memory requires the fatty acid transporter CD36 and is associated with stable deposition of histone H3 lysine 4 trimethylation by methyltransferase Set1A. Furthermore, the proregenerative state of tumor-activated Schwann cells induced by PA may play a role in long-term stimulation of metastasis.

NATURE (2021)

Article Biochemistry & Molecular Biology

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

Chang Cui et al.

Summary: Human neutrophils release ELANE, which can selectively kill a variety of cancer cells, potentially serving as a broad anti-cancer therapy. ELANE liberates the CD95 death domain through a specific mechanism to selectively eradicate cancer cells without significant toxicity to non-cancer cells.
Article Immunology

Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer

Anders Etzerodt et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Alison E. Ringel et al.

Article Endocrinology & Metabolism

Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3

Shannon M. Reilly et al.

NATURE METABOLISM (2020)

Article Endocrinology & Metabolism

Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types

Jinchu Vijay et al.

NATURE METABOLISM (2020)

Article Cell Biology

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Matthew J. Watt et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Article Immunology

Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer

Payal Tiwari et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Multidisciplinary Sciences

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

Mark A. Eckert et al.

NATURE (2019)

Review Medicine, Research & Experimental

Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome

C. Ronald Kahn et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Immunology

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum

WonJae Lee et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Ziming Wang et al.

NATURE MEDICINE (2019)

Article Cell Biology

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance

Hideki Iwamoto et al.

CELL METABOLISM (2018)

Article Biochemistry & Molecular Biology

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

Andras Ladanyi et al.

ONCOGENE (2018)

Article Multidisciplinary Sciences

Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue

Vlad Serbulea et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Macrophages orchestrate breast cancer early dissemination and metastasis

Nina Linde et al.

NATURE COMMUNICATIONS (2018)

Article Oncology

Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins

Maomao Zhang et al.

CANCER DISCOVERY (2018)

Article Multidisciplinary Sciences

Targeting metastasis-initiating cells through the fatty acid receptor CD36

Gloria Pascual et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Medicine, Research & Experimental

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

Clair Crewe et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Cell & Tissue Engineering

Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer

David L. Hermanson et al.

STEM CELLS (2016)

Article Cell & Tissue Engineering

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

Haobin Ye et al.

CELL STEM CELL (2016)

Article Medicine, General & Internal

Body Fatness and Cancer - Viewpoint of the IARC Working Group

Beatrice Lauby-Secretan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Multidisciplinary Sciences

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity

Victor Laurent et al.

NATURE COMMUNICATIONS (2016)

Article Immunology

Inflammation-induced formation of fat-associated lymphoid clusters

Cecile Benezech et al.

NATURE IMMUNOLOGY (2015)

Article Immunology

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

Felix M. Wensveen et al.

NATURE IMMUNOLOGY (2015)

Review Endocrinology & Metabolism

MicroRNA regulatory networks in human adipose tissue and obesity

Peter Arner et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

Article Pathology

Generation of a Dual-Functioning Antitumor Immune Response in the Peritoneal Cavity

Abigail L. Sedlacek et al.

AMERICAN JOURNAL OF PATHOLOGY (2013)

Article Biochemistry & Molecular Biology

Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids

Sharon M. Louie et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)

Review Biochemistry & Molecular Biology

Adipose tissue and adipocytes support tumorigenesis and metastasis

Kristin M. Nieman et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)

Review Biochemistry & Molecular Biology

Fatty acid transport proteins, implications in physiology and disease

Melissa Kazantzis et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Biochemistry & Molecular Biology

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

Saswata Talukdar et al.

NATURE MEDICINE (2012)

Article Obstetrics & Gynecology

Relationship of Type II Diabetes and Metformin Use to Ovarian Cancer Progression, Survival, and Chemosensitivity

Iris L. Romero et al.

OBSTETRICS AND GYNECOLOGY (2012)

Article Biochemistry & Molecular Biology

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

Kristin M. Nieman et al.

NATURE MEDICINE (2011)

Article Biochemistry & Molecular Biology

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

Daniel K. Nomura et al.

Article Immunology

Omental immune aggregates and tumor metastasis within the peritoneal cavity

Elizabeth W. Sorensen et al.

IMMUNOLOGIC RESEARCH (2009)

Article Biochemistry & Molecular Biology

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Satoshi Nishimura et al.

NATURE MEDICINE (2009)

Article Biochemistry & Molecular Biology

Normalization of obesity-associated insulin resistance through immunotherapy

Shawn Winer et al.

NATURE MEDICINE (2009)

Article Endocrinology & Metabolism

Neutrophil Activation in Morbid Obesity, Chronic Activation of Acute Inflammation

Jeroen Nijhuis et al.

OBESITY (2009)

Article Biochemistry & Molecular Biology

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

Vered Elgazar-Carmon et al.

JOURNAL OF LIPID RESEARCH (2008)

Article Endocrinology & Metabolism

Adipokines oversecreted by omental adipose tissue in human obesity

E. Maury et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)

Article Biochemistry & Molecular Biology

IKK-β links inflammation to obesity-induced insulin resistance

MC Arkan et al.

NATURE MEDICINE (2005)

Review Immunology

The chemokine system in diverse forms of macrophage activation and polarization

A Mantovani et al.

TRENDS IN IMMUNOLOGY (2004)

Article Multidisciplinary Sciences

Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors:: Consequences for the NK-mediated killing of dendritic cells

R Castriconi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Medicine, Research & Experimental

A critical role for neutrophil elastase in experimental bullous pemphigoid

Z Liu et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)