期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 198, 期 4, 页码 753-764出版社
WILEY
DOI: 10.1111/bjh.18291
关键词
heavy menstrual bleeding; immune thrombocytopenia; menstrual problems; menstruation; quality of life
类别
资金
- Novartis
This cross-sectional study assessed menstrual problems in premenopausal chronic ITP women and found that the majority of patients experienced clinical menstrual problems. The study also found that the pictorial bleeding assessment calendar (PBAC) and menorrhagia multiattribute scale (MMAS) were associated with heavy menstrual bleeding, but not related to platelet count. Patients using levonorgestrel intrauterine device (LNG-IUD) had lower bleeding scores, and MMAS scores were correlated with fatigue.
Immune thrombocytopenia (ITP) may cause menstrual problems. This cross-sectional study assessed menstrual problems in premenopausal chronic ITP women by several questionnaires, including the pictorial bleeding assessment calendar (PBAC; score >= 100 indicates heavy menstrual bleeding [HMB]), and the menorrhagia multiattribute scale (MMAS). Spearman was used for assessing correlations. A literature review was performed in Pubmed. The cohort comprised 37 women (mean age 31 +/- 9). A total of 29/37 (78%) had experienced clinical menstrual problems in the present or past. Of the 33 patients who returned the PBAC, 13 (39%) had a score of >= 100. The median MMAS score was 79 (IQR 60-95). The PBAC scores correlated with the MMAS. Both questionnaires were unrelated to the platelet count. Patients with a levonorgestrel intrauterine device (LNG-IUD) had lower PBAC scores than patients with other or no hormonal therapy. MMAS scores were correlated with fatigue. The review identified 14 papers. HMB occurred in 6%-55% at ITP diagnosis and 17%-79% during disease. Menstrual symptoms influenced the quality of life, particularly in patients with a low platelet count. This explorative study suggested that HMB is frequent in women with chronic ITP despite management and platelet counts >50 *10(9)/l. An LNG-IUD seemed to reduce blood loss significantly.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据