Diamond-Blackfan anaemia with iron overload: A serious issue

Transfusion-dependent Diamond-Blackfan anaemia (DBA) patients rapidly develop iron overload and frequently experience cardiac complications. The report by Lecornec and colleagues offers useful details on indications and the management of deferiprone, a highly efficient chelator in removing excess cardiac iron but associated with a high risk of agranulocytosis in DBA patients. Commentary on: Nicolas Lecornec and colleagues: Agranulocytosis in patients with Diamond-Blackfan anaemia treated with deferiprone for post-transfusion iron overload: A retrospective study of the French DBA cohort. British Journal of Haematology 2022.

Automated summary

This report provides guidance and management of deferiprone in transfusion-dependent DBA patients, but deferiprone may lead to agranulocytosis in DBA patients.