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Non-aspirin non-steroidal anti-inflammatory drugs in colorectal cancer: a review of clinical studies

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BRITISH JOURNAL OF CANCER
卷 127, 期 10, 页码 1735-1743

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DOI: 10.1038/s41416-022-01882-8

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Aspirin has been shown to play a beneficial role in preventing CRC, while non-aspirin NSAIDs have also been studied and found to potentially decrease CRC incidence in certain high-risk subgroups. However, the use of non-aspirin NSAIDs may come with increased risks of toxicity. Further studies are needed to establish the associations between concurrent aspirin and non-aspirin NSAID use, and CRC-related outcomes.
Colorectal cancer (CRC) chemoprevention is an area of interest. Non-steroidal anti-inflammatory drugs (NSAIDs) are anti-inflammatory agents which have been identified as cancer chemoprevention agents given that inflammation is thought to contribute to tumorigenesis. Most studies have demonstrated that the NSAID, aspirin, plays a beneficial role in the prevention of CRC and colonic adenomas. Non-aspirin NSAIDs (NA-NSAIDs) have also been studied in CRC chemoprevention. There is increasing literature around their role in pre-cancerous polyp prevention and in decreasing CRC incidence and CRC-related outcomes in certain high-risk subgroups. However, the use of NA-NSAIDs may be accompanied by increased risks of toxicity. Further studies are required to establish the associations between concurrent aspirin and NA-NSAID use, and CRC-related outcomes.

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