期刊
BRAIN IMAGING AND BEHAVIOR
卷 16, 期 5, 页码 2021-2036出版社
SPRINGER
DOI: 10.1007/s11682-022-00672-3
关键词
childhood maltreatment; major depressive disorder; functional connectivity; resting-state network; independent component analysis
类别
资金
- Guangdong Natural Science Foundation, China [2015A030313800]
- Guangzhou municipal key discipline in medicine for Guangzhou Brain Hospital [GBH2014-ZD04]
This study reveals that childhood maltreatment is associated with abnormal network architecture in patients with major depressive disorder, characterized by decreased intra-network connectivity and altered inter-network connectivity patterns.
Although childhood maltreatment confers a high risk for the development of major depressive disorder, the neurobiological mechanisms underlying this connection remain unknown. The present study sought to identify the specific resting-state networks associated with childhood maltreatment. We recruited major depressive disorder patients with and without a history of childhood maltreatment (n = 31 and n = 30, respectively) and healthy subjects (n = 80). We used independent component analysis to compute inter- and intra- network connectivity. We found that individuals with major depressive disorder and childhood maltreatment could be characterized by the following network disconnectivity model relative to healthy subjects: (i) decreased intra-network connectivity in the left frontoparietal network and increased intra-network connectivity in the right frontoparietal network, (ii) decreased inter-network connectivity in the posterior default mode network-auditory network, posterior default mode network-limbic system, posterior default mode network-anterior default mode network, auditory network-medial visual network, lateral visual network - medial visual network, medial visual network-sensorimotor network, medial visual network - anterior default mode network, occipital pole visual network-dorsal attention network, and posterior default mode network-anterior default mode network, and (iii) increased inter-network connectivity in the sensorimotor network-ventral attention network, and dorsal attention network-ventral attention network. Moreover, we found significant correlations between the severity of childhood maltreatment and the intra-network connectivity of the frontoparietal network. Our study demonstrated that childhood maltreatment is integrally associated with aberrant network architecture in patients with major depressive disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据