期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 103, 期 -, 页码 28-36出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2022.03.017
关键词
Jackson Heart Study; Perceived Discrimination; Stress; Immune Function; NLR; Neutrophils; Lymphocytes; Health Disparities; African American Health
资金
- Jackson Heart Study (JHS)
- Jackson State University
- Tougaloo College [HHSN268201800013I]
- Mississippi State Department of Health [HHSN268201800014I]
- University of Mississippi Medical Center [HHSN268201800015I]
- National Heart, Lung, and Blood Institute (NHLBI) [HHSN268201800010I, HHSN268201800011I, HHSN268201800012I]
- National Institute for Minority Health and Health Disparities (NIMHD)
- Division of Intramural Research of the National Institute on Minority Health and Health Disparities, National Institutes of Health
- NHLBI
- Office of the Provost [F31HL159910]
- Office for Research
- Northwestern University Information Technology
African American adults suffer disproportionately from various diseases. Perceived discrimination is considered a stressor that contributes to health risk. This study found that high lifetime discrimination was associated with lower neutrophils and neutrophil-to-lymphocyte ratio (NLR), while high perceived burden from discrimination was associated with higher neutrophils and NLR.
African American adults suffer disproportionately from several non-communicable and infectious diseases. Among numerous contributing factors, perceived discrimination is considered a stressor for members of his-torically marginalized groups that contributes to health risk, although biological pathways are incompletely understood. Previous studies have reported associations between stress and both an up-regulation of non-specific (innate) inflammation and down-regulation of specific (adaptive) immunity. While associations between perceived discrimination and markers of inflammation have been explored, it is unclear if this is part of an overall shift that also includes down-regulated adaptive immunity. Relying on a large cross-section of African American adults (n = 3,319) from the Jackson Heart Study (JHS) in Jackson, Mississippi, we tested whether perceived everyday and lifetime discrimination as well as perceived burden from lifetime discrimination were associated with counts of neutrophils (innate), monocytes (innate), lymphocytes (adaptive), and the neutrophil-to-lymphocyte ratio (NLR), derived from complete white blood cell counts with differential. In addition, DNA methylation (DNAm) was measured on the EPIC array in a sub-sample (n = 1,023) of participants, allowing estimation of CD4T, CD8T and B lymphocyte proportions. Unexpectedly, high lifetime discrimination compared to low was significantly associated with lower neutrophils (b :-0.14, [95% CI:-0.24,-0.04]) and a lower NLR (b :-0.15, [95% CI:-0.25,-0.05]) after controlling for confounders. However, high perceived burden from lifetime discrimination was significantly associated with higher neutrophils (b : 0.17, [95% CI: 0.05, 0.30]) and a higher NLR (b : 0.16, [95% CI: 0.03, 0.29]). High perceived burden was also associated with lower lymphocytes among older men, which our analysis suggested might have been attributable to differences in CD4T cells. These findings highlight immune function as a potentially important pathway linking perceived discrimination to health outcomes.
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