期刊
BMC PEDIATRICS
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12887-022-03441-9
关键词
Immune reconstitution inflammatory syndrome-like phenomenon; Acute lymphocytic leukaemia; Pneumocystis Jirovecii pneumonia
类别
资金
- Guangzhou Science and Technology Program key projects [201803010032]
- Bethune Medical Scientific Research Fund Project [SCE111DS]
This case study highlighted the rapid aggravation of pulmonary lesions in a leukemia patient infected with Pneumocystis jirovecii during the process of immune recovery. The use of granulocyte stimulating factors may exacerbate inflammatory responses in the lungs. Further research is needed to explore the timing, dosage, and duration of glucocorticoid treatment and the impact of high-dose methylprednisolone pulse therapy on patient prognosis.
Background Immune reconstitution inflammatory syndrome (IRIS) refers to the phenomenon of intense immune responses against pathogens in patients with AIDS undergoing antiretroviral therapy to reconstitute immune function, resulting in functional impairment of multiple organs. Non-AIDS immunosuppressed hosts may also develop similar manifestations to IRIS during immune recovery. Case presentation An 8-year-old girl presented with acute lymphoblastic leukaemia was admitted for scheduled chemotherapy treatment. During chemotherapy, she experienced pancytopenia and Pneumocystis jirovecii pneumonia, which was diagnosed based on the abnormal shadows observed on chest computed tomography, the elevation of serum beta-D-glucan, and the positive mNGS results of Pneumocystis jirovecii in both sputum and blood. After treatment with Granulocyte Colony-Stimulating Factor, sulfamethoxazole, and caspofungin, aggravation of lung lesions was discovered and severe interstitial lung disease developed in a short period along with a rapidly increasing leukocyte count. Intravenous methylprednisolone pulse therapy was given, but lung function did not improve, and she finally died after the withdrawal of medical care. Conclusions For patients with acute lymphocytic leukaemia infected with Pneumocystis jirovecii, the rapid aggravation of pulmonary lesions in the process of blood recovery and immune reconstitution should raise vigilance against the possibility of IRIS-like reactions. The use of granulocyte stimulating factors may aggravate the inflammatory response in the lungs. The timing, dosage, and duration of treatment of glucocorticoids and the impact of high-dose methylprednisolone pulse therapy on the prognosis of patients should be explored in further research.
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