期刊
BMC INFECTIOUS DISEASES
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12879-022-07562-5
关键词
Rotavirus; Astrovirus; Norovirus; HPeV; Gastroenteritis
资金
- Science, Technology & Innovation Funding Authority (STDF)
- Egyptian Knowledge Bank (EKB)
The study found that the infection rate of HPeV in Egyptian children with AGE is 19%, with a high rate of co-infection with other enteric viruses. Children infected with HPeV alone had milder symptoms, with fever being the main presenting symptom.
Background and aim Human parechovirus (HPeV) has emerged as a pathogen associated with acute gastroenteritis (AGE). Aim To detect the presence of HPeV in the stool samples from Egyptian children with AGE seeking care and the possibility of its co-infection with other enteric viruses. Methodology One hundred stool samples were collected from children attending Mansoura University Children's Hospital with AGE. HPeV and astrovirus were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). At the same time, detection of rotavirus antigen and norovirus was achieved by enzyme-linked immunosorbent assay and rapid immunochromatographic method, respectively. Results The most frequently detected virus was rotavirus (39%), followed by norovirus (27%), HPeV (19%), and astrovirus (12%). Interestingly, the single infection with HPeV was 5%. Among the 19 HPeV positive samples, the co-infection of HPeV with other enteric viruses was detected in 9(43.9%) for rotavirus, 7(36.8%) for norovirus, 2(10.5%) for astrovirus, in 3(15.8%) for rotavirus and norovirus and 1(5.3%) for norovirus and astrovirus. Regarding the clinical presentation, there was no significant difference between children infected with HPeV alone and those infected with viruses other than HPeV alone; fever (p = 0.3), vomiting (p = 0.12), abdominal pain (p = 0.12), and grades of severity (P = 0.82). HPeV alone infected children were of mild severity (60%), and their main presenting symptom was fever (60%). Conclusions Detection of HPeV as a single viral pathogen in the stool of some children with AGE showed that this virus could be a causative agent of AGE in Egyptian children. Therefore, HPeV could be included as one of the viruses screened for AGE diagnosis in children in Egypt.
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