Buckling up against COVID-19 after CAR T-cell therapy

Article Cell Biology

Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity

Catherine Riou et al.

Summary: This study evaluated neutralizing antibody and T cell responses in patients infected with the Beta variant and those infected before its emergence. It found that CD4 and CD8 T cell responses to Beta were preserved overall, despite loss of recognition of immunogenic CD4 epitopes.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Hematology

Impaired immune response to COVID-19 vaccination in patients with B-cell malignancies after CD19 CAR T-cell therapy

Saurabh Dahiya et al.

BLOOD ADVANCES (2022)

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Letter Hematology

Enhanced BNT162b2 vaccine-induced cellular immunity in anti-CD19 CAR T cell-treated patients

Bernice Ling Zhi Oh et al.

BLOOD (2022)

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Letter Hematology

Vaccine-induced T-cell responses against SARS-CoV-2 and its Omicron variant in patients with B cell-depleted lymphoma after CART therapy

Djordje Atanackovic et al.

BLOOD (2022)

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Article Immunology

Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

Chunfeng Li et al.

Summary: The BNT162b2 mRNA vaccine stimulates potent antibody and antigen-specific T cell responses, as well as enhanced innate responses after secondary immunization. Circulating IFN-gamma is mainly produced by natural killer cells and CD8(+) T cells in the draining lymph nodes. The CD8(+) T cell response is dependent on type I interferon-dependent MDA5 signaling.

NATURE IMMUNOLOGY (2022)

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Review Multidisciplinary Sciences

The changing epidemiology of SARS-CoV-2

Katia Koelle et al.

Summary: This review retraces the steps taken by the global community of epidemiologists and evolutionary biologists in understanding and controlling the COVID-19 pandemic. It highlights the crucial roles that mathematical modeling and quantitative analyses of empirical data have played in addressing the challenges faced by this community.

SCIENCE (2022)

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Review Multidisciplinary Sciences

The immunology and immunopathology of COVID-19

Miriam Merad et al.

Summary: Considerable research effort has been focused on deciphering the immune response to SARS-CoV-2 infections and understanding the pathophysiology of COVID-19, including Long Covid syndrome. The hope is that knowledge gained from this research will be applied to studies of inflammatory processes in critical and chronic illnesses in the future.

SCIENCE (2022)

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News Item Multidisciplinary Sciences

HOW THE CORONAVIRUS INFECTS OUR CELLS

Megan Scudellari

NATURE (2021)

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Review Microbiology

SARS-CoV-2 variants, spike mutations and immune escape

William T. Harvey et al.

Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Immunology

Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

Manish Sadarangani et al.

Summary: Most COVID-19 vaccines aim to induce immune responses, particularly neutralizing antibodies (NAbs), against the spike protein of the virus. mRNA vaccines have shown efficacy after just one dose, while adenovirus vaccines elicit polyfunctional antibodies and strong T cell responses. These findings suggest that protection may not solely rely on NAbs but also involve other immune effector mechanisms.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Hematology

Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients

Abi Vijenthira et al.

BLOOD (2020)

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Buckling up against COVID-19 after CAR T-cell therapy

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