期刊
BIOTECHNOLOGY PROGRESS
卷 38, 期 6, 页码 -出版社
WILEY
DOI: 10.1002/btpr.3292
关键词
Middle East respiratory syndrome coronavirus (MERS-CoV); severe acute respiratory syndrome coronavirus (SARS-CoV); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); vaccines; virus-like particle (VLP)
资金
- International Research Network Grant Scheme, Sunway University [STR-IRNGS-SMLS-CVVR-01-2021]
SARS-CoV, MERS-CoV, and SARS-CoV-2 are the most impactful coronaviruses in human history, particularly SARS-CoV-2 which has brought revolutionary changes to vaccinology. Although 10 vaccines have been approved for emergency use against SARS-CoV-2, none of them are based on virus-like particles (VLPs). This review focuses on discussing the major advances in VLP-based vaccine candidates against these coronaviruses.
Severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the most impactful coronaviruses in human history, especially the latter, which brings revolutionary changes to human vaccinology. Due to its high infectivity, the virus spreads rapidly throughout the world and was declared a pandemic in March 2020. A vaccine would normally take more than 10 years to be developed. As such, there is no vaccine available for SARS-CoV and MERS-CoV. Currently, 10 vaccines have been approved for emergency use by World Health Organization (WHO) against SARS-CoV-2. Virus-like particle (VLP)s are nanoparticles resembling the native virus but devoid of the viral genome. Due to their self-adjuvanting properties, VLPs have been explored extensively for vaccine development. However, none of the approved vaccines against SARS-CoV-2 was based on VLP and only 4% of the vaccine candidates in clinical trials were based on VLPs. In the current review, we focused on discussing the major advances in the development of VLP-based vaccine candidates against the SARS-CoV, MERS-CoV, and SARS-CoV-2, including those in clinical and pre-clinical studies, to give a comprehensive overview of the VLP-based vaccines against the coronaviruses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据