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Recent advances, challenges and metabolic engineering strategies in the biosynthesis of 3-hydroxypropionic acid

期刊

BIOTECHNOLOGY AND BIOENGINEERING
卷 119, 期 10, 页码 2639-2668

出版社

WILEY
DOI: 10.1002/bit.28170

关键词

3-hydroxypropionic acid; carbon sources; malonyl-CoA pathway; metabolic engineering; synthetic biology

资金

  1. Talents of High Level Scientific Research Foundation of Qingdao Agricultural University [6651117005, 6651119011]
  2. First class grassland science discipline programme in Shandong Province
  3. Natural Science Foundation of Shandong Province, China [ZR2020MC009]
  4. National Natural Science Foundation of China [31860011]
  5. open project of Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences [CASKLB201805]

向作者/读者索取更多资源

This article focuses on recent advances, challenges, and metabolic engineering strategies in the biosynthesis of 3-hydroxypropionic acid (3-HP). Glucose and glycerol are the major carbon sources for 3-HP production via microbial fermentation, but other carbon sources have also been explored. Synthetic biology and metabolic engineering strategies have been used to increase yield and titer.
As an attractive and valuable platform chemical, 3-hydroxypropionic acid (3-HP) can be used to produce a variety of industrially important commodity chemicals and biodegradable polymers. Moreover, the biosynthesis of 3-HP has drawn much attention in recent years due to its sustainability and environmental friendliness. Here, we focus on recent advances, challenges, and metabolic engineering strategies in the biosynthesis of 3-HP. While glucose and glycerol are major carbon sources for its production of 3-HP via microbial fermentation, other carbon sources have also been explored. To increase yield and titer, synthetic biology and metabolic engineering strategies have been explored, including modifying pathway enzymes, eliminating flux blockages due to byproduct synthesis, eliminating toxic byproducts, and optimizing via genome-scale models. This review also provides insights on future directions for 3-HP biosynthesis.

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