期刊
BIOSENSORS & BIOELECTRONICS
卷 207, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2022.114141
关键词
MXene; ZnO tetrapods; Glucose sensor; Glucose oxidase; Sweat glucose monitoring
类别
资金
- project H2020-MSCA-RISE-2017, 'Novel 1D photonic metal oxide nanostructures for early stage cancer detection' [778157]
- OPUS 14 project by National Science Center of Poland [2017/27/B/ST8/01506]
- project Srodowiskowe interdyscyplinarne studia doktoranckie w zakresienanotechnologii [POWR.03.02.00-00-I032/16]
- Foundation for Polish Science (FNP)
- SONATA BIS project [2020/38/E/ST5/00176]
- Bio Based Industries Joint Undertaking under European Union [745789]
- H2020 Societal Challenges Programme [745789] Funding Source: H2020 Societal Challenges Programme
In this study, a skin-attachable and stretchable electrochemical enzymatic sensor based on ZnO tetrapods and MXene was developed for continuous glucose detection in sweat. The sensor showed enhanced sensitivity, low limit of detection, and a broad linear detection range, making it suitable for glucose detection in human sweat. The sensor also demonstrated good mechanical stability.
Continuous painless glucose monitoring is the greatest desire of more than 422 million diabetics worldwide. Therefore, new non-invasive and convenient approaches to glucose monitoring are more in demand than other tests for microanalytical diagnostic tools. Besides, blood glucose detection can be replaced by continuous glucose monitoring of other human biological fluids (e.g. sweat) collected non-invasively. In this study, a skin-attachable and stretchable electrochemical enzymatic sensor based on ZnO tetrapods (TPs) and a new class of 2D materials -transition metal carbides, known as MXene, was developed and their electroanalytical behavior was tailored for continuous detection glucose in sweat. The high specific area of ZnO TPs and superior electrical conductivity of MXene (Ti3C2Tx) nanoflakes enabled to produce enzymatic electrochemical glucose biosensor with enhanced sensitivity in sweat sample (29 mu A mM(-1) cm(-2)), low limit of detection (LOD asymptotic to 17 mu M), broad linear detection range (LDR = 0.05-0.7 mM) that satisfices glucose detection application in human sweat, and advanced mechanical stability (up to 30% stretching) of the template. The developed skin-attachable stretchable electro-chemical electrodes allowed to monitor the level of glucose in sweat while sugar uptake and during physical activity. Continuous in vivo monitoring of glucose in sweat obtained during 60 min correlated well with data collected by a conventional amperometric blood glucometer in vitro mode. Our findings demonstrate the high potential of developed ZnO/MXene skin-attachable stretchable sensors for biomedical applications on a daily basis.
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