☆ 4.7 Article

Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents

BIOORGANIC CHEMISTRY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Chemistry, Medicinal

An unanticipated discovery towards novel naphthalimide corbelled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a

Peng-Li Zhang et al.

Summary: The study introduced a novel antibacterial framework and demonstrated through experiments that the new compound exhibited strong inhibition against MRSA, showed excellent membrane selectivity, and effectively alleviated bacterial resistance.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Medicinal

Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant Escherichia coli

Hang Sun et al.

Summary: Natural berberine-derived azolyl ethanols were designed and synthesized as new structural antibacterial agents to combat bacterial resistance, with potent activity against multidrug-resistant Escherichia coli. These compounds could rapidly kill bacteria and eradicate biofilms, aiding in alleviating bacterial resistance development.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Polypharmacology: The science of multi-targeting molecules

Abbas Kabir et al.

Summary: Polypharmacology refers to the concept where a molecule can interact with two or more targets simultaneously, offering advantages over traditional single-targeting molecules. Multi-targeting drugs are more efficacious and effective in complex diseases like cancer. Predicting and intentionally incorporating promiscuity in molecules can lead to the design of polypharmacological drugs, which have numerous applications in drug repurposing. Despite being more difficult to design, with current technologies and information, it is plausible for researchers to unlock the advantages of polypharmacological drugs.

PHARMACOLOGICAL RESEARCH (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Novel metronidazole-derived three-component hybrids as promising broad-spectrum agents to combat oppressive bacterial resistance

Fen-Fen Li et al.

Summary: This study developed a class of novel metronidazole-derived three-component hybrids as promising antibacterial therapeutic alternatives. The active molecule 6b showed excellent ability to suppress the growth of drug-resistant E. coli and could effectively retard the development of bacterial drug resistance. Mechanism exploration revealed that 6b could destruct the bacterial cytoplasmic membrane, obstruct DNA replication, and cause metabolic stagnation and the accumulation of reactive oxygen species.

BIOORGANIC CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Medicinal

Dihydropyrimidinone imidazoles as unique structural antibacterial agents for drug-resistant gram-negative pathogens

Xi Yang et al.

Summary: The health crisis caused by severe multidrug resistance is driving the need for new alternative antibacterial drugs. A library of structurally unique dihydropyrimidinone imidazoles was developed as potential antibacterial agents. One compound, sulfamethoxazole hybridized dihydropyrimidinone imidazole 8b, exhibited excellent antibacterial activity against multidrug-resistant K. pneumonia and A. baumanii, and showed low cytotoxicity and good biofilm inhibition ability.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of unique thiazolidinone-conjugated coumarins as novel broad spectrum antibacterial agents

Xun-Cai Yang et al.

Summary: Unique coumarin conjugates with thiazolidinone were utilized as antibacterial modulators to combat multidrug-resistant bacterial infections. The indole-incorporated coumarin thiazolidinone conjugate 14a exhibited broad-spectrum antibacterial activity, low cytotoxicity, and favorable pharmacokinetic properties.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Article Chemistry, Medicinal

Unique Carbazole-Oxadiazole Derivatives as New Potential Antibiotics for Combating Gram-Positive and -Negative Bacteria

Yun-Peng Xie et al.

Summary: Novel carbazole-oxadiazoles were developed as potential antibacterial agents and showed predominant inhibitory effects on both Gram-positive and -negative bacteria, especially in impeding the growth of MRSA and Pseudomonas aeruginosa ATCC 27853. The compounds exhibited low cytotoxicity and low tendency to develop resistance, and could disintegrate bacterial cell membranes to exert excellent antibacterial effects.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

添加到收藏夹

Article

Synthesis of naphthalimide triazoles with a novel structuralframework and their anti-<italic>Aspergillus</italic><italic> fumigatus</italic> effects

Peng-Li Zhang et al.

Scientia Sinica Chimica (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis and Biological Evaluation of Quinazolonethiazoles as New Potential Conquerors towards Pseudomonas Aeruginosa

Jie Wang et al.

Summary: Novel quinazolonthiazoles, particularly compound 7d, exhibited superior antimicrobial activity with low toxicity, suggesting potential mechanisms of action involving disruption of bacterial membrane permeability and interference with DNA-topoisomerase IV interactions. These findings provide valuable insights for the development of quinazolonthiazoles as new antimicrobial agents against drug-resistant pathogens.

CHINESE JOURNAL OF CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms

Yan-Fei Sui et al.

Summary: Novel purinylthiazolylethanone derivative 8c shows significant inhibitory action against C. albicans, with no detectable resistance and low toxicity. The compound kills fungi by damaging cell wall and membrane disruption, hinder the growth of fungal biofilm. Imbalance of redox equilibrium leads to oxidative damage to fungal cells and fungicidal effect.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Copper Clusters: An Effective Antibacterial for Eradicating Multidrug-Resistant Bacterial Infection In Vitro and In Vivo

Xiangchun Zhang et al.

Summary: CuCs is a novel antibacterial molecule with broad-spectrum and excellent antibacterial activity, able to disrupt bacterial wall structure, regulate GSH/GSSG ratio, induce reactive oxygen species production, and ultimately lead to bacterial death. In vivo studies in mice demonstrate that CuCs can significantly treat skin wound infections and sepsis caused by MRSA, with similar therapeutic efficacy as mupirocin ointment and vancomycin. Compared to silver and platinum clusters, CuCs show extremely low cytotoxicity to normal mammalian cells.

ADVANCED FUNCTIONAL MATERIALS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Reactive oxygen and nitrogen species and innate immune response

Saad S. Al-Shehri

Summary: The innate immune system plays a crucial role in fighting pathogens, with reactive oxygen and nitrogen species serving as key components. However, high concentrations of these reactive species may damage microbial biomolecules. The system can generate more biocidal agents through interactions between its components, and deficiencies in these antimicrobial agents can lead to severe infections and immunocompromised diseases.

BIOCHIMIE (2021)

添加到收藏夹

Article Chemistry, Medicinal

Design and structural optimization of novel 2H-benzo[h]chromene derivatives that target AcrB and reverse bacterial multidrug resistance

Yinhu Wang et al.

Summary: This study designed novel chromanone and 2H-benzo[h]chromene derivatives as potential efflux pump inhibitors targeting Escherichia coli AcrB. Results showed that compounds WK2, WL7, and WL10 exhibited broad-spectrum and high-efficiency efflux inhibitory activity, suggesting their potential as ideal AcrB inhibitors. Molecular modeling revealed that the strong pi-pi stacking interactions and hydrogen bond networks were key factors contributing to tight binding of AcrB.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Physical

Microwave irradiated one pot, three component synthesis of a new series of hybrid coumarin based thiazoles: Antibacterial evaluation and molecular docking studies

Srikanth Mamidala et al.

Summary: A series of new coumarin based thiazoles were synthesized by microwave irradiation, and their structures were confirmed by spectral and analytical data. In vitro cytotoxic activity screening showed one compound with activity close to the standard, and docking studies supported the in vitro results.

JOURNAL OF MOLECULAR STRUCTURE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Pyrimidinetrione-imidazoles as a Unique Structural Type of Potential Agents towards Candida Albicans: Design, Synthesis and Biological Evaluation

Yan-Fei Sui et al.

Summary: A series of potential antifungal agents have been developed, with compound 5f showing good inhibitory effects on Candida albicans without obvious resistance. Its fungicidal capacity may be attributed to its interference with the membrane and DNA, indicating promising applications in the field of antifungal research.

CHEMISTRY-AN ASIAN JOURNAL (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Design and Synthesis of Sulfanilamide Aminophosphonates as Novel Antibacterial Agents towards Escherichia coli

Juan Wang et al.

Summary: A new class of sulfanilamide aminophosphonates showed activity against drug resistant bacteria and low toxicity to human cells, indicating potential as novel antibacterial agents. Mechanistic studies revealed that the compound disrupted bacterial cell membrane and formed a stable complex leading to bacterial death.

CHINESE JOURNAL OF CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity

Jin-Ping Chen et al.

Summary: A novel class of 7-thiazoxime quinolones has been developed as potential antimicrobial agents to combat quinolone resistance. Biological assays have shown that these compounds, particularly methyl acetate oxime derivative 6l, exhibit potent antibacterial activity against MRSA, with the ability to improve potency and alleviate bacterial resistance when used in combination with ciprofloxacin. The mechanism of action involves destroying the cell membrane, binding with DNA gyrase in MRSA DNA, and downregulating key genes, suggesting promise for combating MRSA infection.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Agriculture, Multidisciplinary

Design, Synthesis, and Fungicidal Activities of Novel Piperidyl Thiazole Derivatives Containing Oxime Ether or Oxime Ester Moieties

Qiang Bian et al.

Summary: A series of novel piperidyl thiazole derivatives were designed and synthesized to evaluate their fungicidal activities, with oxime ether compound 11b showing the highest activity in vitro. Compared to oxime ether compounds, oxime ester compounds exhibited significantly reduced activities against Phytophthora capsici.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors

Jie Wang et al.

Summary: A class of quinazolone thiazoles has been identified as potential antibacterial conquerors with favorable bacteriostatic efficiencies. Compound 5j, featuring the 4-trifluoromethylphenyl group, showed superior performance against Escherichia coli and Pseudomonas aeruginosa, and could hinder the formation of bacterial biofilms by triggering reactive oxygen species generation. Additionally, compound 5j exhibited powerful antibacterial properties by disintegrating bacterial membranes, suppressing dehydrogenase, and intercalating into DNA.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Molecular design and preparation of 2-aminothiazole sulfanilamide oximes as membrane active antibacterial agents for drug resistant Acinetobacter baumannii

Juan Wang et al.

Summary: A series of new membrane active antibacterial agents were developed with good biocompatibility and ability to eradicate biofilm. Compound 10c showed superiority in treating drug-resistant A. baumannii infection and effectively interfered with cellular oxidoreduction balance by disturbing the cell membrane.

BIOORGANIC CHEMISTRY (2021)

添加到收藏夹

Article Agriculture, Multidisciplinary

Natural Berberine-Hybridized Benzimidazoles as Novel Unique Bactericides against Staphylococcus aureus

Hang Sun et al.

Summary: Berberine-hybridized benzimidazoles, such as the 2,4-dichlorobenzyl derivative 7d, showed potent antibacterial efficacy against Staphylococcus aureus, with the ability to eradicate bacterial biofilm and low toxicity towards mammalian cells. Combination with norfloxacin enhanced the antibacterial efficacy, while development of bacterial resistance was not observed. Mechanism studies indicated that the active molecule 7d damaged membrane integrity, stimulated ROS generation, and bound with DNA and S. aureus sortase A, exerting powerful antibacterial ability in treating S. aureus in the livestock industry.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Novel carbazole-oxadiazoles as potential Staphylococcus aureus germicides

Yun-Peng Xie et al.

Summary: A newly synthesized antibacterial compound showed effective inhibitory activity against Staphylococcus aureus and other bacteria, with low tendency to induce resistance. The compound also demonstrated abilities to disrupt bacterial biofilm and interfere with DNA, while exhibiting low toxicity towards human cells.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ethylenic conjugated coumarin thiazolidinediones as new efficient antimicrobial modulators against clinical methicillin-resistant Staphylococcus aureus

Chun-Fang Hu et al.

BIOORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Novel diindoloazepinone derivatives as DNA minor groove binding agents with selective topoisomerase I inhibition: Design, synthesis, biological evaluation and docking studies

Manasa Kadagathur et al.

BIOORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synthesis and antibacterial evaluation against resistant Gram-negative bacteria of monobactams bearing various substituents on oxime residue

Zhi-Wen Li et al.

BIOORGANIC CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Medicinal

Thiazoles, Their Benzofused Systems, and Thiazolidinone Derivatives: Versatile and Promising Tools to Combat Antibiotic Resistance

Stella Cascioferro et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Medicinal

Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections

Shuimu Lin et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Ultrasound-assisted multicomponent synthesis of 4H-pyrans in water and DNA binding studies

Fernando Auria-Luna et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Chemistry, Medicinal

Development of Bis-cyclic Imidazolidine-4-one Derivatives as Potent Antibacterial Agents

Minghui Wang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Medicinal

Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase

Gregory S. Basarab et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

A fast impedance-based antimicrobial susceptibility test

Daniel C. Spencer et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Chemistry, Medicinal

Antibacterial activities with the structure-activity relationship of coumarin derivatives

Hua-Li Qin et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

添加到收藏夹

Article Chemistry, Medicinal

Structural Basis for DNA Gyrase Interaction with Coumermycin A1

Arnaud Vanden Broeck et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Review Microbiology

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research

Nicholas A. Turner et al.

NATURE REVIEWS MICROBIOLOGY (2019)

添加到收藏夹

Article Chemistry, Medicinal

Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation

Liang-Liang Wang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Review Chemistry, Multidisciplinary

Coumarin-Based Small-Molecule Fluorescent Chemosensors

Duxia Cao et al.

CHEMICAL REVIEWS (2019)

添加到收藏夹

Review Polymer Science

A review on the construction of hydrogel scaffolds by various chemically techniques for tissue engineering

Parinaz Nezhad-Mokhtari et al.

EUROPEAN POLYMER JOURNAL (2019)

添加到收藏夹

Article Chemistry, Medicinal

A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV

Liang-Liang Wang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Chemistry, Medicinal

Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus

Zhen-Zhen Li et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

A new antibiotic selectively kills Gram-negative pathogens

Yu Imai et al.

NATURE (2019)

添加到收藏夹

Article Chemistry, Medicinal

Alkynyl Gold(I) complexes derived from 3-hydroxyflavones as multi-targeted drugs against colon cancer

Ines Marmol et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Sulfonamide-Derived Four-Component Molecular Hybrids as Novel DNA-Targeting Membrane Active Potentiators against Clinical Escherichia coil

Yuan-Yuan Hu et al.

MOLECULAR PHARMACEUTICS (2019)

添加到收藏夹

Article Nanoscience & Nanotechnology

Mechanistic Insight into the Antibacterial Activity of Chitosan Exfoliated MoS2 Nanosheets: Membrane Damage, Metabolic Inactivation, and Oxidative Stress

Shounak Roy et al.

ACS APPLIED BIO MATERIALS (2019)

添加到收藏夹

Article Chemistry, Organic

Novel potential artificial MRSA DNA intercalators: synthesis and biological evaluation of berberine-derived thiazolidinediones

Hang Sun et al.

ORGANIC CHEMISTRY FRONTIERS (2019)

添加到收藏夹

Review Infectious Diseases

A Mini-Review on Ceftaroline in Bacteremia Patients with Methicillin-Resistant Staphylococcus aureus (MRSA) Infections

Nicole Lounsbury et al.

ANTIBIOTICS-BASEL (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy

Catherine A. McLellan et al.

NATURE CHEMICAL BIOLOGY (2018)

添加到收藏夹

Review Medicine, Research & Experimental

DNA gyrase inhibitors: Progress and synthesis of potent compounds as antibacterial agents

Tabassum Khan et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

添加到收藏夹

Article Chemistry, Medicinal

Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton

Swetha Kameswari Maddili et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

添加到收藏夹

Review Chemistry, Medicinal

New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV

Syed Lal Badshah et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Article Chemistry, Physical

New thiazolyl-coumarin hybrids: Design, synthesis, characterization, X-ray crystal structure, antibacterial and antiviral evaluation

Hasnah Osman et al.

JOURNAL OF MOLECULAR STRUCTURE (2018)

添加到收藏夹

Article Chemistry, Medicinal

Tau-Centric Multitarget Approach for Alzheimer's Disease: Development of First-in-Class Dual Glycogen Synthase Kinase 3 beta and Tau-Aggregation Inhibitors

Annachiara Gandini et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

添加到收藏夹

Article Chemistry, Medicinal

Naphthylthiazoles: Targeting Multidrug-Resistant and Intracellular Staphylococcus aureus with Biofilm Disruption Activity

Mohamed Hagras et al.

ACS INFECTIOUS DISEASES (2018)

添加到收藏夹

Article Chemistry, Medicinal

Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA)

Shuimu Lin et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Medicinal

Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria

Allimuthu T. Dharmaraja

JOURNAL OF MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Development of DNA Nanostructures for High-Affinity Binding to Human Serum Albumin

Auraelie Lacroix et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of pyrano isoxazoline/isoxazole annulated coumarins via intramolecular nitrile oxide cycloaddition and their cytotoxicity

C. Krishna et al.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY (2017)

添加到收藏夹

Article Microbiology

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

Jonathan M. Stokes et al.

NATURE MICROBIOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents

Zhen-Zhen Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis and biological evaluation of new benzimidazole-thiazolidinedione hybrids as potential cytotoxic and apoptosis inducing agents

Pankaj Sharma et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Article Chemistry, Medicinal

Identification of Potential Off-target Toxicity Liabilities of Catechol-O-methyltransferase Inhibitors by Differential Competition Capture Compound Mass Spectrometry

Lisa von Kleist et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Article Chemistry, Medicinal

Novel 3-Aminothiazolquinolones: Design, Synthesis, Bioactive Evaluation, SARs, and Preliminary Antibacterial Mechanism

Sheng-Feng Cui et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

添加到收藏夹

Article Plant Sciences

Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds

Joshua J. Kellogg et al.

JOURNAL OF NATURAL PRODUCTS (2016)

添加到收藏夹

Review Multidisciplinary Sciences

Antibacterial drug discovery in the resistance era

Eric D. Brown et al.

NATURE (2016)

添加到收藏夹

Review Chemistry, Medicinal

Bioactive thiazole and benzothiazole derivatives

Abdul Rouf et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

添加到收藏夹

Article Chemistry, Medicinal

Membrane Active Phenylalanine Conjugated Lipophilic Norspermidine Derivatives with Selective Antibacterial Activity

Mohini M. Konai et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

添加到收藏夹

Article Chemistry, Medicinal

Kinesin Spindle Protein Inhibitors with Diaryl Amine Scaffolds: Crystal Packing Analysis for Improved Aqueous Solubility

Tomoki Takeuchi et al.

ACS MEDICINAL CHEMISTRY LETTERS (2014)

添加到收藏夹

Article Chemistry, Medicinal

Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora A/B kinase inhibitors

Youguang Zheng et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

添加到收藏夹

Article Pharmacology & Pharmacy

Current Developments of Coumarin Compounds in Medicinal Chemistry

Xin-Mei Peng et al.

CURRENT PHARMACEUTICAL DESIGN (2013)

添加到收藏夹

Article Agriculture, Multidisciplinary

Molecular Spectroscopic Studies of Farrerol Interaction with Calf Thymus DNA

Guowen Zhang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Anti-AIDS agents 82: Synthesis of seco-(3′R,4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents

Jian Tang et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2010)

添加到收藏夹

Article Chemistry, Medicinal

Synthesis and antibacterial activity of 5-ylidenethiazolidin-4-ones and 5-benzylidene-4,6-pyrimidinediones

Tihomir Tomasic et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.