相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Oxidative stress-A direct bridge to central nervous system homeostatic dysfunction and Alzheimer's disease
Mai M. Anwar
CELL BIOCHEMISTRY AND FUNCTION (2022)
Protective effects of hydroxy-α-sanshool from the pericarp of Zanthoxylum bungeanum Maxim. On D-galactose/AlCl3-induced Alzheimer's disease-like mice via Nrf2/HO-1 signaling pathways
Yujie Liu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2022)
Roles and Mechanisms of the Protein Quality Control System in Alzheimer's Disease
Yaping Liu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
New Promising Therapeutic Avenues of Curcumin in Brain Diseases
Tarek Benameur et al.
MOLECULES (2022)
mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesis
Deepthi Rapaka et al.
NEUROCHEMISTRY INTERNATIONAL (2022)
Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition
Sravan Gopalkrishnashetty Sreenivasmurthy et al.
PHYTOMEDICINE (2022)
Impairment of the autophagy-lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential
Wei Zhang et al.
ACTA PHARMACEUTICA SINICA B (2022)
Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer’s disease therapy
Chuanbin Yang et al.
Acta Pharmaceutica Sinica B (2022)
Panax notoginseng saponins protect PC12 cells against Aβ induced injury via promoting parkin-mediated mitophagy
Yixuan Jiang et al.
JOURNAL OF ETHNOPHARMACOLOGY (2022)
The contribution of altered neuronal autophagy to neurodegeneration
Alessia Filippone et al.
PHARMACOLOGY & THERAPEUTICS (2022)
Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
Amy F. T. Arnsten et al.
ALZHEIMERS & DEMENTIA (2021)
Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways
Eman A. Mohamed et al.
JOURNAL OF ETHNOPHARMACOLOGY (2021)
Novel target for treating Alzheimer's Diseases: Crosstalk between the Nrf2 pathway and autophagy
Weiwei Zhang et al.
AGEING RESEARCH REVIEWS (2021)
NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines
Xuerui Wang et al.
BIOMEDICINE & PHARMACOTHERAPY (2021)
Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities
Marlene F. Schmidt et al.
CELL DEATH AND DIFFERENTIATION (2021)
Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective
Francois Le Guerroue et al.
CELL DEATH AND DIFFERENTIATION (2021)
Autophagy-Dependent Increased ADAM10 Mature Protein Induced by TFEB Overexpression Is Mediated Through PPARα
Hongjie Wang et al.
MOLECULAR NEUROBIOLOGY (2021)
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Fangda Leng et al.
NATURE REVIEWS NEUROLOGY (2021)
Platycodin D Inhibits β-Amyloid-Induced Inflammation and Oxidative Stress in BV-2 Cells Via Suppressing TLR4/NF-κB Signaling Pathway and Activating Nrf2/HO-1 Signaling Pathway
Jing Zhang et al.
NEUROCHEMICAL RESEARCH (2021)
Pinoresinol diglucoside attenuates neuroinflammation, apoptosis and oxidative stress in a mice model with Alzheimer's disease
Shuangyuan Lei et al.
NEUROREPORT (2021)
The Role of PPAR Alpha in the Modulation of Innate Immunity
Maja Grabacka et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Ganoderic Acid A To Alleviate Neuroinflammation of Alzheimer's Disease in Mice by Regulating the Imbalance of the Th17/Tregs Axis
Yan Zhang et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)
Suan-Zao-Ren Decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 transgenic mice
Qing-Hua Long et al.
CHINESE MEDICINE (2021)
Shenzhiling oral liquid protects the myelin sheath against Alzheimer's disease through the PI3K/Akt-mTOR pathway
Mingcui Zheng et al.
JOURNAL OF ETHNOPHARMACOLOGY (2021)
Sanweidoukou decoction, a Chinese herbal formula, ameliorates β-amyloid protein-induced neuronal insult via modulating MAPK/NF-κB signaling pathways: Studies in vivo and in vitro
Feng-Mao An et al.
JOURNAL OF ETHNOPHARMACOLOGY (2021)
Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease
Ashok Iyaswamy et al.
PHYTOMEDICINE (2021)
Yuan-zhi-san inhibits tau protein aggregation in an Aβ1-40-induced Alzheimer's disease rat model via the ubiquitin-proteasome system
Bin Li et al.
MOLECULAR MEDICINE REPORTS (2021)
Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling
Yue Fu et al.
FRONTIERS IN NEUROSCIENCE (2021)
Mechanisms and Therapeutic Implications of GSK-3 in Treating Neurodegeneration
Ido Rippin et al.
CELLS (2021)
Antioxidant Compound, Oxyresveratrol, Inhibits APP Production through the AMPK/ULK1/mTOR-Mediated Autophagy Pathway in Mouse Cortical Astrocytes
Md. Ataur Rahman et al.
ANTIOXIDANTS (2021)
Resveratrol, Metabolic Dysregulation, and Alzheimer's Disease: Considerations for Neurogenerative Disease
Alex J. T. Yang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Prolonged Treatment with Centella asiatica Improves Memory, Reduces Amyloid-β Pathology, and Activates NRF2-Regulated Antioxidant Response Pathway in 5xFAD Mice
Jonathan A. Zweig et al.
JOURNAL OF ALZHEIMERS DISEASE (2021)
Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer's Disease Pathogenesis?
Lucrezia Bruno et al.
CELLS (2021)
Role of microgliosis, oxidative stress and associated neuroinflammation in the pathogenesis of Parkinson?s disease: The therapeutic role of Nrf2 activators
Saravanan Jayaram et al.
NEUROCHEMISTRY INTERNATIONAL (2021)
GSK-3 and Tau: A Key Duet in Alzheimer's Disease
Carmen Laura Sayas et al.
CELLS (2021)
The PI3K/Akt signaling axis in Alzheimer's disease: a valuable target to stimulate or suppress?
Elham Razani et al.
CELL STRESS & CHAPERONES (2021)
A Review of Oxidative Stress Products and Related Genes in Early Alzheimer's Disease
Federica Cioffi et al.
JOURNAL OF ALZHEIMERS DISEASE (2021)
Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-κB signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus
Yuan Han et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)
PPAR control of metabolism and cardiovascular functions
David Montaigne et al.
NATURE REVIEWS CARDIOLOGY (2021)
Neuroprotective Effects of Rhynchophylline Against Aβ1-42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2-ARE Activation
Pan Jiang et al.
NEUROCHEMICAL RESEARCH (2021)
Cornel Iridoid Glycoside Protects Against STAT1-Dependent Synapse and Memory Deficits by Increasing N-Methyl-D-aspartate Receptor Expression in a Tau Transgenic Mice
Denglei Ma et al.
FRONTIERS IN AGING NEUROSCIENCE (2021)
Combination of Polygoni Multiflori Radix Praeparata and Acori Tatarinowii Rhizoma Alleviates Learning and Memory Impairment in Scopolamine-Treated Mice by Regulating Synaptic-Related Proteins
Funan Ning et al.
FRONTIERS IN PHARMACOLOGY (2021)
Oxyphylla A ameliorates cognitive deficits and alleviates neuropathology via the Akt-GSK3β and Nrf2-Keap1-HO-1 pathways in vitro and in vivo murine models of Alzheimer's disease
Yaqi Bian et al.
JOURNAL OF ADVANCED RESEARCH (2021)
The JAK/STAT signaling pathway: from bench to clinic
Xiaoyi Hu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)
Autophagy-independent function of lipidated LC3 essential for TFEB activation during the lysosomal damage responses
Shuhei Nakamura et al.
AUTOPHAGY (2021)
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
Rongcan Luo et al.
AUTOPHAGY (2020)
Dementia in China: epidemiology, clinical management, and research advances
Longfei Jia et al.
LANCET NEUROLOGY (2020)
The Notch pathway in CNS homeostasis and neurodegeneration
Diana M. Ho et al.
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY (2020)
NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models
Ashok Iyaswamy et al.
JOURNAL OF FOOD AND DRUG ANALYSIS (2020)
Targeting autophagy-related protein kinases for potential therapeutic purpose
Honggang Xiang et al.
ACTA PHARMACEUTICA SINICA B (2020)
The neuroprotective effects of SIRT1 in mice carrying the APP/PS1 double-transgenic mutation and in SH-SY5Y cells over-expressing human APP670/671 may involve elevated levels of α7 nicotinic acetylcholine receptors
Kun Cao et al.
AGING-US (2020)
Molecular regulation of autophagy machinery by mTOR-dependent and -independent pathways
Md Abdul Alim Al-Bari et al.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2020)
Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance
Ying Chen et al.
BIOMEDICINE & PHARMACOTHERAPY (2020)
Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer's Disease
Yuan Zhao et al.
CURRENT NEUROPHARMACOLOGY (2020)
mTOR at the nexus of nutrition, growth, ageing and disease
Grace Y. Liu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Benefits and Harms of Prescription Drugs and Supplements for Treatment of Clinical Alzheimer-Type Dementia A Systematic Review and Meta-analysis
Howard A. Fink et al.
ANNALS OF INTERNAL MEDICINE (2020)
The Bewildering Effect of AMPK Activators in Alzheimer's Disease: Review of the Current Evidence
Brhane Teklebrhan Assefa et al.
BIOMED RESEARCH INTERNATIONAL (2020)
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease
Sahil Khan et al.
CURRENT NEUROPHARMACOLOGY (2020)
Corydalis edulis total alkaloids (CETA) ameliorates cognitive dysfunction in rat model of Alzheimer disease through regulation of the antioxidant stress and MAP2/NF-κB
Shuai Liang et al.
JOURNAL OF ETHNOPHARMACOLOGY (2020)
Cornel iridoid glycoside ameliorates cognitive deficits in APP/PS1/tau triple transgenic mice by attenuating amyloid-beta, tau hyperphosphorylation and neurotrophic dysfunction
Cuicui Yang et al.
ANNALS OF TRANSLATIONAL MEDICINE (2020)
SnapShot: JAK-STAT Signaling II
Alejandro V. Villarino et al.
CELL (2020)
Anti-inflammatory effects of higenamine (Hig) on LPS-activated mouse microglia (BV2) through NF-κB and Nrf2/HO-1 signaling pathways
Songwei Yang et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2020)
Targeting Amyloidogenic Processing of APP in Alzheimer's Disease
Jing Zhao et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)
NRF2, a Transcription Factor for Stress Response and Beyond
Feng He et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease
Dominic S. A. Simpson et al.
ANTIOXIDANTS (2020)
When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration
Patrycja Michalska et al.
ANTIOXIDANTS (2020)
Natural phenylethanoid glycosides isolated from Callicarpa kwangtungensis suppressed lipopolysaccharide-mediated inflammatory response via activating Keap1/Nrf2/HO-1 pathway in RAW 264.7 macrophages cell
Aizhi Wu et al.
JOURNAL OF ETHNOPHARMACOLOGY (2020)
Astragalus polysaccharide alleviates cognitive impairment and β-amyloid accumulation in APP/PS1 mice via Nrf2 pathway
Xiude Qin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease
Veerta Sharma et al.
BIOMEDICINE & PHARMACOTHERAPY (2020)
Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer's Disease
Sharmeelavathi Krishnan et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Forsythoside B attenuates memory impairment and neuroinflammation via inhibition on NF-κB signaling in Alzheimer's disease
Fan'ge Kong et al.
JOURNAL OF NEUROINFLAMMATION (2020)
Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro
Bo Ding et al.
JOURNAL OF NEUROINFLAMMATION (2020)
Nrf2: a dark horse in Alzheimer's disease treatment
Alsiddig Osama et al.
AGEING RESEARCH REVIEWS (2020)
Sulforaphane mitigates LPS-induced neuroinflammation through modulation of Cezanne/NF-κB signalling
Zeng-chun Wang et al.
LIFE SCIENCES (2020)
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
Sarmistha Saha et al.
MOLECULES (2020)
Anti-inflammatory and immunomodulatory effects of baicalin in cerebrovascular and neurological disorders
Yuanyuan Li et al.
BRAIN RESEARCH BULLETIN (2020)
Resveratrol extracted from Chinese herbal medicines: A novel therapeutic strategy for lung diseases
Bo-ning Ma et al.
CHINESE HERBAL MEDICINES (2020)
Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease
A. Iyaswamy et al.
FRONTIERS IN PHARMACOLOGY (2020)
Astaxanthin attenuates oxidative stress and immune impairment ind-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway
Zhiqing Chen et al.
FOOD & FUNCTION (2020)
Polygala tenuifolia: a source for anti-Alzheimer's disease drugs
Xinxin Deng et al.
PHARMACEUTICAL BIOLOGY (2020)
Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy
Zhenru Xu et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)
Therapeutic potential of JAK/STAT pathway modulation in mood disorders
Aisha S. Shariq et al.
REVIEWS IN THE NEUROSCIENCES (2019)
Modulating NRF2 in Disease: Timing Is Everything
Matthew Dodson et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)
NF-kappa B as a Key Mediator of Brain Inflammation in Alzheimer's Disease
Chul Ju Hwang et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2019)
Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway
Xin Jin et al.
CNS NEUROSCIENCE & THERAPEUTICS (2019)
Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence
Marziyeh Hajialyani et al.
MOLECULES (2019)
The Protective Effects of PSM-04 Against Beta Amyloid-Induced Neurotoxicity in Primary Cortical Neurons and an Animal Model of Alzheimer's Disease
Hyunjun Park et al.
FRONTIERS IN PHARMACOLOGY (2019)
Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-κB Inhibition and Nrf2/HO-1 Activation
Lalita Subedi et al.
CELLS (2019)
Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model
Sujyoti Chandra et al.
NEUROBIOLOGY OF DISEASE (2019)
Dual Role of Autophagy in Diseases of the Central Nervous System
Tamara Bar-Yosef et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer's Disease Therapeutic Development
Alejo J. Nevado-Holgado et al.
CELLS (2019)
Autophagy-Independent Functions of the Autophagy Machinery
Lorenzo Galluzzi et al.
CELL (2019)
USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells
Svetlana Piatnitskaia et al.
SCIENTIFIC REPORTS (2019)
Long-term efficacy of Chinese medicine Bushen Capsule on cognition and brain activity in patients with amnestic mild cognitive impairment
Junying Zhang et al.
PHARMACOLOGICAL RESEARCH (2019)
Yizhiqingxin Formula Alleviates Cognitive Deficits and Enhances Autophagy via mTOR Signaling Pathway Modulation in Early Onset Alzheimer's Disease Mice
Yang Yang et al.
FRONTIERS IN PHARMACOLOGY (2019)
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
Justin M. Long et al.
CELL (2019)
Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway
Wei Yang et al.
FOOD AND CHEMICAL TOXICOLOGY (2019)
Anti-Inflammatory and Anticancer Properties of Bioactive Compounds from Sesamum indicum L.-A Review
Ming-Shun Wu et al.
MOLECULES (2019)
Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice
Donald G. Matthews et al.
ANTIOXIDANTS (2019)
Molecular logic of mTORC1 signalling as a metabolic rheostat
Alexander J. Valvezan et al.
NATURE METABOLISM (2019)
Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells
Chiara Porro et al.
BIOLOGY-BASEL (2019)
Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-kappa B signaling
Yan Hong et al.
ARCHIVES OF PHARMACAL RESEARCH (2018)
The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease
Ji Cheng et al.
AGING CELL (2018)
Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases
Zhaoqi Yan et al.
CLINICAL IMMUNOLOGY (2018)
Oxidative Stress, Amyloid-beta Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease
D. Allan Butterfield et al.
JOURNAL OF ALZHEIMERS DISEASE (2018)
Ethnopharmacology, phytochemistry, and pharmacology of Cornus officinalis Sieb. et Zucc
Jun Huang et al.
JOURNAL OF ETHNOPHARMACOLOGY (2018)
Citri Reticulatae Pericarpium (Chenpi): Botany, ethnopharmacology, phytochemistry, and pharmacology of a frequently used traditional Chinese medicine
Xin Yu et al.
JOURNAL OF ETHNOPHARMACOLOGY (2018)
Modulating inflammation through the negative regulation of NF-B signaling
Daniel E. Rothschild et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2018)
SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy
Sang-Won Min et al.
JOURNAL OF NEUROSCIENCE (2018)
Mechanism and medical implications of mammalian autophagy
Ivan Dikic et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Tau-targeting therapies for Alzheimer disease
Erin E. Congdon et al.
NATURE REVIEWS NEUROLOGY (2018)
Amyloid toxicity in Alzheimer's disease
Allison B. Reiss et al.
REVIEWS IN THE NEUROSCIENCES (2018)
Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer's Disease
Hianara A. Bustamante et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2018)
Activation of Nrf2 signaling by salvianolic acid C attenuates NF-κB mediated inflammatory response both in vivo and in vitro
Junke Song et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2018)
natureOUTLOOK ALZHEIMER'S DISEASE
Richard Hodson
NATURE (2018)
Structure and Physiological Regulation of AMPK
Yan Yan et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Uncaria rhynchophylla ameliorates amyloid beta deposition and amyloid beta-mediated pathology in 5XFAD mice
Soo Jung Shin et al.
NEUROCHEMISTRY INTERNATIONAL (2018)
Mechanisms of NF-kappa B p65 and strategies for therapeutic manipulation
Sivagami Giridharan et al.
JOURNAL OF INFLAMMATION RESEARCH (2018)
mTORC1 as the main gateway to autophagy
Yoana Rabanal-Ruiz et al.
SIGNALLING MECHANISMS IN AUTOPHAGY (2017)
Tenuigenin inhibits LPS-induced inflammatory responses in microglia via activating the Nrf2-mediated HO-1 signaling pathway
Xiaokun Wang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2017)
Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway
Beita Zhao et al.
FOOD AND CHEMICAL TOXICOLOGY (2017)
Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease
Eric Tonnies et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
The Essential Medicinal Chemistry of Curcumin
Kathryn M. Nelson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
Fiona M. Menzies et al.
NEURON (2017)
RESVERATROL AMELIORATES SPATIAL LEARNING MEMORY IMPAIRMENT INDUCED BY Aβ1-42 IN RATS
Rui Wang et al.
NEUROSCIENCE (2017)
Resveratrol as a Natural Autophagy Regulator for Prevention and Treatment of Alzheimer's Disease
Xianjuan Kou et al.
NUTRIENTS (2017)
A modified formulation of Huanglian-Jie-Du-Tang reduces memory impairments and β-amyloid plaques in a triple transgenic mouse model of Alzheimer's disease
Siva Sundara Kumar Durairajan et al.
SCIENTIFIC REPORTS (2017)
Opportunities and challenges provided by crosstalk between signalling pathways in cancer
A. Prahallad et al.
ONCOGENE (2016)
Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy
Matteo Bordi et al.
AUTOPHAGY (2016)
Resveratrol Attenuates Aβ25-35 Caused Neurotoxicity by Inducing Autophagy Through the TyrRS-PARP1-SIRT1 Signaling Pathway
Haoyue Deng et al.
NEUROCHEMICAL RESEARCH (2016)
Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation
Ting-Ting Chu et al.
CELL CHEMICAL BIOLOGY (2016)
Dissecting molecular cross-talk between Nrf2 and NF-kappa B response pathways
Joanna D. Wardyn et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2015)
Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD
Antonella Tramutola et al.
JOURNAL OF NEUROCHEMISTRY (2015)
Neuroinflammation in Alzheimer's disease
Michael T. Heneka et al.
LANCET NEUROLOGY (2015)
Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease
Giuseppe Verdile et al.
MEDIATORS OF INFLAMMATION (2015)
Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy
Esperanza Arias et al.
MOLECULAR CELL (2015)
Aβ peptide secretion is reduced by Radix Polygalae-induced autophagy via activation of the AMPK/mTOR pathway
Huan Zhao et al.
MOLECULAR MEDICINE REPORTS (2015)
Autophagy in Alzheimer's disease
Ameneh Zare-shahabadi et al.
REVIEWS IN THE NEUROSCIENCES (2015)
Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer's disease
Romina J. Gentier et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2015)
NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review
Ruey-Horng Shih et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2015)
Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice
Giuseppe D'Agostino et al.
MOLECULAR METABOLISM (2015)
Control of Inflammatory Responses: a New Paradigm for the Treatment of Chronic Neuronal Diseases
Joo Hong Woo et al.
EXPERIMENTAL NEUROBIOLOGY (2015)
Interleukin-10 Production in Response to Amyloid-β Differs between Slow and Fast Decliners in Patients with Alzheimer's Disease
Delphine Asselineau et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Signaling pathway cross talk in Alzheimer's disease
Juan A. Godoy et al.
CELL COMMUNICATION AND SIGNALING (2014)
Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells
Zhongfeng Xue et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice
Chen Wang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
Targeting the mTOR Signaling Network for Alzheimer's Disease Therapy
Chong Wang et al.
MOLECULAR NEUROBIOLOGY (2014)
The role of protein clearance mechanisms in organismal ageing and age-related diseases
David Vilchez et al.
NATURE COMMUNICATIONS (2014)
PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
Cora O' Neill
EXPERIMENTAL GERONTOLOGY (2013)
Reductive stress in young healthy individuals at risk of Alzheimer disease
Mari-Carmen Badia et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
The role of autophagy in neurodegenerative disease
Ralph A. Nixon
NATURE MEDICINE (2013)
Tau degradation: The ubiquitin-proteasome system versus the autophagy-lysosome system
Min Jae Lee et al.
PROGRESS IN NEUROBIOLOGY (2013)
Aβ Secretion and Plaque Formation Depend on Autophagy
Per Nilsson et al.
CELL REPORTS (2013)
Regulation of Cyclic AMP Response Element Binding and Hippocampal Plasticity-Related Genes by Peroxisome Proliferator-Activated Receptor α
Avik Roy et al.
CELL REPORTS (2013)
Alzheimer Mechanisms and Therapeutic Strategies
Yadong Huang et al.
CELL (2012)
Roles of AMP-activated Protein Kinase in Alzheimer's Disease
Zhiyou Cai et al.
NEUROMOLECULAR MEDICINE (2012)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential
Ananta Paine et al.
BIOCHEMICAL PHARMACOLOGY (2010)
Oxidative stress, inflammation, and cancer How are they linked?
Simone Reuter et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
Shaday Michan et al.
JOURNAL OF NEUROSCIENCE (2010)
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
Jun Gao et al.
NATURE (2010)
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
Sang-Won Min et al.
NEURON (2010)
Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease
Carl Julien et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)
Green Tea (-)-Epigallocatechin-3-Gallate Inhibits β-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-κB Pathways in Mice
Jae Woong Lee et al.
JOURNAL OF NUTRITION (2009)
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
Saravanan S. Karuppagounder et al.
NEUROCHEMISTRY INTERNATIONAL (2009)
Amyloid activates GSK-3β to aggravate neuronal tauopathy in bigenic mice
Dick Terwel et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK
Guang-Hui Liu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
Barry Boland et al.
JOURNAL OF NEUROSCIENCE (2008)
Aβ inhibits the proteasome and enhances amyloid and tau accumulation
Bertrand P. Tseng et al.
NEUROBIOLOGY OF AGING (2008)
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
In Hye Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
New regulators of NF-κB in inflammation
Sankar Ghosh et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Increased level of active GSK-3β in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration
K. Leroy et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2007)
Expression of Nrf2 in neurodegenerative diseases
Chenere P. Ramsey et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes
Christina Curtis et al.
GENOME BIOLOGY (2007)
Transgenic mouse models for Alzheimer's disease:: the role of GSK-3β in combined amyloid and tau-pathology
D. Muyllaert et al.
REVUE NEUROLOGIQUE (2006)
Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3
Tobias Engel et al.
JOURNAL OF NEUROSCIENCE (2006)
β-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system
CG Almeida et al.
JOURNAL OF NEUROSCIENCE (2006)
Macroautophagy -: a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
WH Yu et al.
JOURNAL OF CELL BIOLOGY (2005)
Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain
X Li et al.
FEBS JOURNAL (2005)
Autophagy and its possible roles in nervous system diseases, damage and repair
David C. Rubinszfein et al.
AUTOPHAGY (2005)
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
RA Nixon et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain
X Li et al.
NEUROREPORT (2004)
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease
WL An et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Spatial learning deficit in transgenic mice that conditionally over-express GSK-3β in the brain but do not form tau filaments
F Hernández et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice
JJ Lucas et al.
EMBO JOURNAL (2001)
Impaired proteasome function in Alzheimer's disease
JN Keller et al.
JOURNAL OF NEUROCHEMISTRY (2000)