期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 151, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2022.113143
关键词
Wound healing; Scar formation; DPP-4; CD26; DPP-4 inhibitors
资金
- National Natural Science Foundation of China Science [81770876]
- Natural Science Foundation of Jiangsu Province [BK20191141]
- Top Talent Support Program for young and middle-aged people of Wuxi Health Committee [BJ2020044, BJ2020057, HB2020043]
- Fundamental Research Funds of Health and Family Planning Commission of Wuxi [M202024]
- special program for translational medicine research of Wuxi translational medicine center [2020DHYB07, 2020DHYB03]
- Key special project of precision medicine of Wuxi health commission [J202101]
This paper introduces the wound healing process and the effects of DPP-4/CD26 on cells involved in different stages of wound healing. It discusses the potential of DPP-4/CD26 as a therapeutic target for promoting wound healing and inhibiting scar formation.
Wound healing is a complex and long-term process consisting of hemostasis, inflammation, proliferation, and maturation/remodeling. These four stages overlap and influence each other; they affect wound healing in different ways, and if they do not function perfectly, they may cause scarring, proliferative scarring and keloid formation. A therapeutic target affecting wound healing in multiple ways will help the healing process proceed more effectively. DPP-4/CD26 is a multifunctional dimorphic glycoprotein widely distributed on the surface of a variety of cells, including fibroblasts and keratin-forming cells. It has been found to affect periwound inflammation, re-epithelialization, extracellular matrix secretion and skin fibrosis and is a potential target for promoting wound healing and inhibiting scar formation. After presenting a brief introduction of the wound healing process and DPP-4/CD26, this paper summarizes the effects of DPP-4/CD26 on cells involved in different stages of wound healing and discusses the feasibility of DPP-4/CD26 as a multifunctional target for the treatment of wound healing and inhibition of scar formation.
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