☆ 4.7 Article

Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease

BIOMEDICINE & PHARMACOTHERAPY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Food Science & Technology

An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans

Jose M. Romero-Marquez et al.

Summary: This study characterized an olive leaf extract enriched in oleuropein and found that it exhibited no toxicity and improved oxidative stress and proteotoxicity. The study also identified potential molecular mechanisms involving multiple signaling pathways.

FOOD AND CHEMICAL TOXICOLOGY (2022)

添加到收藏夹

Article Chemistry, Applied

Strawberry (Fragaria x ananassa cv. Romina) methanolic extract attenuates Alzheimer's beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans

Maria D. Navarro-Hortal et al.

Summary: Bioactive compounds from strawberries, such as ellagic acid and pelargonidin-3-glucoside, along with minerals like K, Mg, P, and Ca, were found in a methanolic extract of Romina strawberry variety. The extract showed antioxidant properties, prevented oxidative stress and delayed amyloid-13 induced paralysis in an experimental model. Molecular mechanisms involving DAF-16/FOXO and SKN-1/NRF2 signaling pathways were partially responsible for the observed effects.

FOOD CHEMISTRY (2022)

添加到收藏夹

Review Biology

Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review

Biswajit Panda et al.

Summary: Exosomes, derived from mesenchymal stem cells, have emerged as a novel therapeutic approach that overcomes drawbacks of cell-based therapy in regenerative medicine. These nano-vesicles have the potential to be used in nanotherapeutics and drug delivery systems, attracting attention for their potency in regenerative medicine.

LIFE-BASEL (2021)

添加到收藏夹

Article Cell Biology

Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway

Xinhui Wang et al.

Summary: Exosomes play a role in the development and progression of Alzheimer's disease, with potential to reduce A beta deposition and promote cognitive function recovery in AD mice by activating the SphK/S1P signaling pathway. This suggests that exosomes containing S1P/SphK could be explored as a potential AD cure.

CELL BIOLOGY INTERNATIONAL (2021)

添加到收藏夹

Article Oncology

Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway

Xuehui Wang et al.

Summary: Hsa_circ_0005273 is overexpressed in breast cancer tissues and cell lines, promoting BC progression by regulating the miR-200a-3p/YAP1 axis and inactivating the Hippo signaling pathway. Depletion of hsa_circ_0005273 inhibits tumor cell proliferation, migration, and cell cycle progression, suggesting it as a potential therapeutic target for breast cancer.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Exosomes derived from miR-188-3p-modified adipose-derived mesenchymal stem cells protect Parkinson's disease

Qiang Li et al.

Summary: Parkinson's disease is the second most common neuro-degenerative disease characterized by irreversible damage of dopamine neurons. Studies have shown that NLRP3 inflammasome and CDK5-mediated autophagy are important in PD. miR-188-3p is a potential therapeutic target for treating PD.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

添加到收藏夹

Review Cell & Tissue Engineering

Mesenchymal stem cells-derived exosomes for drug delivery

Yao Sun et al.

Summary: Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. Researchers have increasingly focused on using exosomes for drug delivery, especially MSC-EXOs, due to their immune properties, tumor-homing properties, and elastic properties. This review article summarizes the characteristics of MSC-EXOs and introduces production, purification, and drug loading methods to address existing problems and provide suggestions for future studies.

STEM CELL RESEARCH & THERAPY (2021)

添加到收藏夹

Article Neurosciences

Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment

Nashmin Fayazi et al.

Summary: Stem cells and their secretions are considered an effective treatment for neurodegenerative diseases, providing features such as neuroprotection, remyelination, and reduction of neural inflammation.

MOLECULAR NEUROBIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Coenzyme Q10 and Immune Function: An Overview

David Mantle et al.

Summary: Coenzyme Q10 plays crucial roles in the immune system as an electron carrier, antioxidant, and anti-inflammatory agent. It also functions within lysosomes, improving immune system function.

ANTIOXIDANTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer's Disease: The Role of Antioxidants in Prevention and Treatment

Gabriela Juszczyk et al.

Summary: Chronic stress leads to oxidative stress in the brain, contributing to depression and AD. Antioxidants play a significant role in treating these diseases, with compounds like curcumin, Vitamin E, and selenium showing promising results for AD treatment, and curcumin, zinc, and selenium demonstrating potential in depression treatment.

ANTIOXIDANTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Linking Oxidative Stress and Proteinopathy in Alzheimer's Disease

Chanchal Sharma et al.

Summary: Proteinopathy and excessive production of reactive oxygen species are key factors contributing to neuronal toxicity in Alzheimer's disease. Beta-amyloid and tau proteins play a significant role in proteinopathy in AD, which is closely related to ROS production. The mechanisms of proteinopathy and ROS production work together to drive the pathology observed in aging brains, ultimately leading to oxidative stress and neurodegeneration.

ANTIOXIDANTS (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review

Martina Rekatsina et al.

ADVANCES IN THERAPY (2020)

添加到收藏夹

Article Cell & Tissue Engineering

Exosomal 2 ',3 '-CNP from mesenchymal stem cells promotes hippocampus CA1 neurogenesis/neuritogenesis and contributes to rescue of cognition/learning deficiencies of damaged brain

Shih-Yin Chen et al.

STEM CELLS TRANSLATIONAL MEDICINE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

Francisco Miguel Gutierrez-Mariscal et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Promising Opportunities for Treating Neurodegenerative Diseases with Mesenchymal Stem Cell-Derived Exosomes

Reut Guy et al.

BIOMOLECULES (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease

Xinyi Ma et al.

JOURNAL OF CONTROLLED RELEASE (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles

Yao Qi et al.

DRUG DELIVERY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Exosomes: biogenesis, biologic function and clinical potential

Yuan Zhang et al.

CELL AND BIOSCIENCE (2019)

添加到收藏夹

Article Geriatrics & Gerontology

RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's disease

Guo-hong Cui et al.

IMMUNITY & AGEING (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

Can coenzyme Q10 supplementation effectively reduce human tumor necrosis factor-α and interleukin-6 levels in chronic inflammatory diseases? A systematic review and meta-analysis of randomized controlled trials

Farnaz Farsi et al.

PHARMACOLOGICAL RESEARCH (2019)

添加到收藏夹

Review Cell Biology

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

Laura M. Doyle et al.

CELLS (2019)

添加到收藏夹

Review Neurosciences

The neuropathological diagnosis of Alzheimer's disease

Michael A. DeTure et al.

MOLECULAR NEURODEGENERATION (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid- oligomers

Mariana A. de Godoy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

添加到收藏夹

Article

Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

Mei Jiang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice

Guo-Hong Cui et al.

FASEB JOURNAL (2018)

添加到收藏夹

Review Pharmacology & Pharmacy

Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: A focus on human studies

Francesca Pistollato et al.

PHARMACOLOGICAL RESEARCH (2018)

添加到收藏夹

Review Neurosciences

Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer's disease Neurons

Ravi Rajmohan et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF

Lus F. Martins et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Review Nutrition & Dietetics

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

Francesca Pistollato et al.

NUTRITION REVIEWS (2016)

添加到收藏夹

Review Pharmacology & Pharmacy

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

Dinh Ha et al.

ACTA PHARMACEUTICA SINICA B (2016)

添加到收藏夹

Article Multidisciplinary Sciences

SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis

Alejandro Amador-Arjona et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Drug Delivery Systems, CNS Protection, and the Blood Brain Barrier

Ravi Kant Upadhyay

BIOMED RESEARCH INTERNATIONAL (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression

Ruopeng Feng et al.

BIOCHEMICAL JOURNAL (2013)

添加到收藏夹

Article Endocrinology & Metabolism

Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats

Hongqi Xin et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

Takeshi Katsuda et al.

SCIENTIFIC REPORTS (2013)

添加到收藏夹

Article Clinical Neurology

Behavioral and Psychological Symptoms of Dementia

J. Cerejeira et al.

Frontiers in Neurology (2012)

添加到收藏夹

Article Neurosciences

Coenzyme Q10 Decreases Amyloid Pathology and Improves Behavior in a Transgenic Mouse Model of Alzheimer's Disease

Magali Dumont et al.

JOURNAL OF ALZHEIMERS DISEASE (2011)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.