期刊
BIOMATERIALS
卷 286, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2022.121604
关键词
Immunomodulation; Bone regeneration; Biomaterials; Diseases
资金
- NIH [R01DE024772, R01AR074502]
- Stanford Maternal and Children's Health Institute Postdoctoral Fellowship
- National Science Foundation Predoctoral fellowship
- EDGE Fellowship
This review discusses the progress in immunomodulation research for bone applications using biomaterials and cell-based strategies, with a focus on different disease types. The role of the immune system in orthopedic applications, including prolonging orthopaedic implant lifetime and enhancing fracture healing, is reviewed. Recent research progress in harnessing immunomodulatory strategies for regenerating critical-sized, long bone or cranial bone defects, and treating osteolytic bone diseases is also discussed.
Tissue engineering strategies for treating bone loss to date have largely focused on targeting stem cells or vascularization. Immune cells, including macrophages and T cells, can also indirectly enhance bone healing via cytokine secretion to interact with other bone niche cells. Bone niche cues and local immune environment vary depending on anatomical location, size of defects and disease types. As such, it is critical to evaluate the role of the immune system in the context of specific bone niche and different disease types. This review focuses on immunomodulation research for bone applications using biomaterials and cell-based strategies, with a unique perspective from different disease types. We first reviewed applications for prolonging orthopaedic implant lifetime and enhancing fracture healing, two clinical challenges where immunomodulatory strategies were initially developed for orthopedic applications. We then reviewed recent research progress in harnessing immunomodulatory strategies for regenerating critical-sized, long bone or cranial bone defects, and treating osteolytic bone diseases. Remaining gaps in knowledge, future directions and opportunities were also discussed.
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