期刊
BIOMACROMOLECULES
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.2c00516
关键词
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资金
- UK Engineering and Physical Sciences Research Council (EPSRC) National Productivity Investment Fund (NPIF) [EP/R512564/1, 2065445]
- EPSRC [EP/R003823/1]
- UK Royal Society [RG160449]
- CONICET (Argentina) [A103355]
This article discusses the development of biomaterials capable of controlling the release of agrochemicals/biologics/drugs/fragrances. By using degradable electroactive polymers, controlled release of a clinically relevant drug was achieved and shown to have good cytocompatibility in vitro. These stimuli-responsive biomaterials have potential applications in the fields of technology and medicine.
Biomaterials capable of precisely controlling the delivery of agrochemicals/biologics/drugs/fragrances have significant markets in the agriscience/healthcare industries. Here, we report the development of degradable electroactive polymers and their application for the controlled delivery of a clinically relevant drug (the anti-inflammatory dexamethasone phosphate, DMP). Electroactive copolymers composed of blocks of polycaprolactone (PCL) and naturally occurring electroactive pyrrole oligomers (e.g., bilirubin, biliverdin, and hemin) were prepared and solution-processed to produce films (optionally doped with DMP). A combination of in silico/in vitro/in vivo studies demonstrated the cytocompatibility of the polymers. The release of DMP in response to the application of an electrical stimulus was observed to be enhanced by ca. 10-30% relative to the passive release from nonstimulated samples in vitro. Such stimuli-responsive biomaterials have the potential for integration devices capable of delivering a variety of molecules for technical/medical applications.
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