4.4 Review

Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Nutrition & Dietetics

Caloric Restriction Mimetics in Nutrition and Clinical Trials

Sebastian J. Hofer et al.

Summary: Human diet and dietary patterns play a crucial role in health status, with high-calorie Western-style diets linked to non-communicable diseases and calorie-reduced health-promoting diets showing promising results. Pharmacological Caloric Restriction Mimetics (CRMs) have attracted interest as potential candidates to mimic effects induced by caloric restriction.

FRONTIERS IN NUTRITION (2021)

Review Biochemical Research Methods

Beyond calorie restriction: aging as a biological target for nutrient therapies

Steven N. Austad et al.

Summary: The important discovery that reducing food intake can extend life and improve health is being challenged by research showing that protein restriction, intermittent fasting, and the timing of eating also impact health. This suggests that optimizing human diets will require a personalized approach.

CURRENT OPINION IN BIOTECHNOLOGY (2021)

Article Biochemistry & Molecular Biology

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho

Gisele Pereira Dias et al.

Summary: The study showed that intermittent fasting improves long-term memory retention, increases neurogenesis in the hippocampus, and enhances cognition by upregulating the longevity gene Klotho, particularly through enhancing adult hippocampal neurogenesis.

MOLECULAR PSYCHIATRY (2021)

Review Geriatrics & Gerontology

Aberrant mitochondrial function in ageing and cancer

Julia C. Whitehall et al.

BIOGERONTOLOGY (2020)

Article Geriatrics & Gerontology

Ketogenic diet attenuates aging-associated myocardial remodeling and dysfunction in mice

Yunhua Yu et al.

EXPERIMENTAL GERONTOLOGY (2020)

Review Cell Biology

Mitochondrial dysfunction in fibrotic diseases

Xinyu Li et al.

CELL DEATH DISCOVERY (2020)

Article Biochemistry & Molecular Biology

A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1-SIRT3-UCP2 Axis

Md Mahdi Hasan-Olive et al.

NEUROCHEMICAL RESEARCH (2019)

Review Endocrinology & Metabolism

Hormetic Effects of Phytochemicals on Health and Longevity

Jan Martel et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

Article Nutrition & Dietetics

The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study

Stephen D. Anton et al.

NUTRIENTS (2019)

Article Geriatrics & Gerontology

Age and Ketogenic Diet Have Dissociable Effects on Synapse-Related Gene Expression Between Hippocampal Subregions

Abbi R. Hernandez et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Review Biochemistry & Molecular Biology

Causal roles of mitochondrial dynamics in longevity and healthy aging

Arpit Sharma et al.

EMBO REPORTS (2019)

Review Cell Biology

Regulation of reproduction and longevity by nutrient-sensing pathways

Nicole M. Templeman et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Geriatrics & Gerontology

Effect of Aging on Mitochondrial Energetics in the Human Atria

Larisa Emelyanova et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2018)

Review Cell Biology

AMPK: guardian of metabolism and mitochondrial homeostasis

Sebastien Herzig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Correction Cell Biology

A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice (vol 26, pg 539, 2017)

Megan N. Roberts et al.

CELL METABOLISM (2018)

Review Biochemistry & Molecular Biology

Mitochondrial dynamics: overview of molecular mechanisms

Lisa Tilokani et al.

MITOCHONDRIAL DISEASES (2018)

Review Cell Biology

The effect of fasting or calorie restriction on autophagy induction: A review of the literature

Mohammad Bagherniya et al.

AGEING RESEARCH REVIEWS (2018)

Review Geriatrics & Gerontology

Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?

Guillermo Lopez-Lluch et al.

BIOGERONTOLOGY (2018)

Article Integrative & Complementary Medicine

Glycolysis inhibition via mTOR suppression is a key step in cardamonin-induced autophagy in SKOV3 cells

Daohua Shi et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

Article Geriatrics & Gerontology

Physical exercise increases Sestrin 2 protein levels and induces autophagy in the skeletal muscle of old mice

Luciene Lenhare et al.

EXPERIMENTAL GERONTOLOGY (2017)

Article Biochemistry & Molecular Biology

Crosstalk between Mitochondrial Fission and Oxidative Stress in Paraquat-Induced Apoptosis in Mouse Alveolar Type II Cells

Guangju Zhao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2017)

Article Cell Biology

Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity

Guillermo Lopez-Lluch

MECHANISMS OF AGEING AND DEVELOPMENT (2017)

Article Multidisciplinary Sciences

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass

Jessica B. Spinelli et al.

SCIENCE (2017)

Review Endocrinology & Metabolism

Nutrient Sensing and the Oxidative Stress Response

Hanzhi Luo et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)

Review Endocrinology & Metabolism

AMPK as a Therapeutic Target for Treating Metabolic Diseases

Emily A. Day et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)

Review Biochemistry & Molecular Biology

NAD+ in Aging: Molecular Mechanisms and Translational Implications

Evandro F. Fang et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Review Geriatrics & Gerontology

Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

Kerstin Boengler et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2017)

Review Cell Biology

Recent Insights into the Biological Functions of Sestrins in Health and Disease

Menglong Wang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

Article Biochemistry & Molecular Biology

Microbial Genetic Composition Tunes Host Longevity

Bing Han et al.

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth, Metabolism, and Disease

Robert A. Saxton et al.

Article Cell Biology

FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction

N. Makino et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2016)

Review Biochemistry & Molecular Biology

Dietary Protein, Metabolism, and Aging

George A. Soultoukis et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)

Article Biochemistry & Molecular Biology

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

Michael D. Buck et al.

Review Biochemistry & Molecular Biology

Metabolic Control of Longevity

Carlos Lopez-Otin et al.

Article Pharmacology & Pharmacy

AMPK Function in Aging Process

Roco Ruiz et al.

CURRENT DRUG TARGETS (2016)

Review Biochemistry & Molecular Biology

Respiratory supercomplexes and the functional segmentation of the CoQ pool

Raquel Moreno-Loshuertos et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Review Geriatrics & Gerontology

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island

Sebastian I. Arriola Apelo et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2016)

Article Neurosciences

SHORT-TERM DIETARY RESTRICTION IN OLD ZEBRAFISH CHANGES CELL SENESCENCE MECHANISMS

Ayca Arslan-Ergul et al.

NEUROSCIENCE (2016)

Article Nutrition & Dietetics

Time-restricted feeding reduces adiposity in mice fed a high-fat diet

Sneha Sundaram et al.

NUTRITION RESEARCH (2016)

Article Cell Biology

In Situ Evaluation of Oxidative Stress in Rat Fatty Liver Induced by a Methionine- and Choline-Deficient Diet

Isabel Freitas et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Review Cell Biology

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

D. Grahame Hardie et al.

TRENDS IN CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy

Amy E. Vincent et al.

SCIENTIFIC REPORTS (2016)

Review Physiology

Mitochondrial Quality Control and Muscle Mass Maintenance

Vanina Romanello et al.

FRONTIERS IN PHYSIOLOGY (2016)

Review Cell Biology

Calorie restriction mimetics: Can you have your cake and eat it, too?

Donald K. Ingram et al.

AGEING RESEARCH REVIEWS (2015)

Review Biochemistry & Molecular Biology

The Interplay Between Respiratory Supercomplexes and ROS in Aging

Maria Luisa Genova et al.

ANTIOXIDANTS & REDOX SIGNALING (2015)

Article Biochemistry & Molecular Biology

Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal

Kristopher Burkewitz et al.

Article Medicine, General & Internal

Biological theories of aging

Martin S. Lipsky

DM DISEASE-A-MONTH (2015)

Review Biochemistry & Molecular Biology

Autophagy in malignant transformation and cancer progression

Lorenzo Galluzzi et al.

EMBO JOURNAL (2015)

Article Endocrinology & Metabolism

Regulation of mTOR Activity in Snell Dwarf and GH Receptor Gene-Disrupted Mice

Graham Dominick et al.

ENDOCRINOLOGY (2015)

Review Biochemistry & Molecular Biology

Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease

Abishek Iyer et al.

FASEB JOURNAL (2015)

Review Biochemistry & Molecular Biology

The metabolic regulation of aging

Toren Finkel

NATURE MEDICINE (2015)

Article Oncology

Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice

Jean-Philippe Leduc-Gaudet et al.

ONCOTARGET (2015)

Review Endocrinology & Metabolism

Mitochondrial dysfunction as a central event for mechanisms underlying insulin resistance: the roles of long chain fatty acids

Mohamad Hafizi Abu Bakar et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2015)

Article Clinical Neurology

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

Katherine H. M. Cox et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2015)

Review Pharmacology & Pharmacy

Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease

A. R. Hall et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

Article Biochemistry & Molecular Biology

Aging Research-Where Do We Stand and Where Are We Going?

Leonard Guarente

Editorial Material Biochemistry & Molecular Biology

Geroscience: Linking Aging to Chronic Disease

Brian K. Kennedy et al.

Review Cell Biology

AMPK at the Nexus of Energetics and Aging

Kristopher Burkewitz et al.

CELL METABOLISM (2014)

Review Cell Biology

Fasting: Molecular Mechanisms and Clinical Applications

Valter D. Longo et al.

CELL METABOLISM (2014)

Article Pharmacology & Pharmacy

Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity

Gabriella Testa et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Article Geriatrics & Gerontology

Mice Producing Reduced Levels of Insulin-Like Growth Factor Type 1 Display an Increase in Maximum, but not Mean, Life Span

Antonello Lorenzini et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

Article Multidisciplinary Sciences

Diversity of ageing across the tree of life

Owen R. Jones et al.

NATURE (2014)

Review Cell Biology

Making new contacts: the mTOR network in metabolism and signalling crosstalk

Mitsugu Shimobayashi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Cell Biology

mTOR inhibition improves immune function in the elderly

Joan B. Mannick et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

Review Biotechnology & Applied Microbiology

Mitochondrial Aging and Age-Related Dysfunction of Mitochondria

Dimitry A. Chistiakov et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Review Biochemistry & Molecular Biology

Hydrogen peroxide sensing, signaling and regulation of transcription factors

H. Susana Marinho et al.

REDOX BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease

Renato X. Santos et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

Mitochondrial Metabolic Reprogramming Induced by Calorie Restriction

Alejandro Martin-Montalvo et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Review Cell Biology

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

Jun Hee Lee et al.

CELL METABOLISM (2013)

Review Geriatrics & Gerontology

Metabolic adaptations to methionine restriction that benefit health and lifespan in rodents

Carmen E. Perrone et al.

EXPERIMENTAL GERONTOLOGY (2013)

Review Cell Biology

Calorie restriction and sirtuins revisited

Leonard Guarente

GENES & DEVELOPMENT (2013)

Review Medicine, General & Internal

Mitochondrial Dynamics - Mitochondrial Fission and Fusion in Human Diseases

Stephen L. Archer

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

Age-dependent dissociation of ATP synthase dimers and loss of inner-membrane cristae in mitochondria

Bertram Daum et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

Issam Ben-Sahra et al.

SCIENCE (2013)

Article Physiology

Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury

Masayuki Ishihara et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2013)

Article Geriatrics & Gerontology

Effect of calorie restriction and refeeding on skin wound healing in the rat

Nicole D. Hunt et al.

Review Biochemistry & Molecular Biology

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

Vittorio Calabrese et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Article Biochemistry & Molecular Biology

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

Huei-Fen Jheng et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Review Cell Biology

Sirtuins as regulators of metabolism and healthspan

Riekelt H. Houtkooper et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Review Cell Biology

AMPK: a nutrient and energy sensor that maintains energy homeostasis

D. Grahame Hardie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Geriatrics & Gerontology

Dietary restriction regulates brain acetylcholinesterase in female mice as a function of age

Kitlangki Suchiang et al.

BIOGERONTOLOGY (2011)

Article Biochemistry & Molecular Biology

Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death

M. Thomenius et al.

CELL DEATH AND DIFFERENTIATION (2011)

Article Genetics & Heredity

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

Robbie Loewith et al.

GENETICS (2011)

Review Genetics & Heredity

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

Antero Salminen et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2011)

Review Biochemistry & Molecular Biology

Caloric restriction

John R. Speakman et al.

MOLECULAR ASPECTS OF MEDICINE (2011)

Review Cell Biology

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

Maria M. Mihaylova et al.

NATURE CELL BIOLOGY (2011)

Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

Article Multidisciplinary Sciences

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

Fredrik H. Sterky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cardiac & Cardiovascular Systems

Two Close, Too Close Sarcoplasmic Reticulum-Mitochondrial Crosstalk and Cardiomyocyte Fate

Gerald W. Dorn et al.

CIRCULATION RESEARCH (2010)

Article Cell Biology

The role of insulin/IGF-like signaling in C. elegans longevity and aging

Rachel Kaletsky et al.

DISEASE MODELS & MECHANISMS (2010)

Review Pharmacology & Pharmacy

Role of Sirtuin 1 in metabolic regulation

Jose P. Silva et al.

DRUG DISCOVERY TODAY (2010)

Review Endocrinology & Metabolism

The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes

Mary-Elizabeth Patti et al.

ENDOCRINE REVIEWS (2010)

Article Geriatrics & Gerontology

Impaired quality control of mitochondria: Aging from a new perspective

Tobias A. Weber et al.

EXPERIMENTAL GERONTOLOGY (2010)

Review Biochemistry & Molecular Biology

Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess

Kathryn E. Wellen et al.

MOLECULAR CELL (2010)

Article Multidisciplinary Sciences

Regulation of Cellular Metabolism by Protein Lysine Acetylation

Shimin Zhao et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

Wen Yang et al.

PLOS BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Is the oxidative stress theory of aging dead?

Viviana I. Perez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2009)

Article Cardiac & Cardiovascular Systems

Mitochondrial OPA1, apoptosis, and heart failure

Le Chen et al.

CARDIOVASCULAR RESEARCH (2009)

Article Biochemistry & Molecular Biology

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

Jeffrey M. Copeland et al.

CURRENT BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin

Giuseppe Petrosillo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Article Biochemistry & Molecular Biology

Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA

Adriana Malena et al.

HUMAN MOLECULAR GENETICS (2009)

Article Biochemistry & Molecular Biology

ULK1•ATG13•FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

Ian G. Ganley et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Editorial Material Cell Biology

mTOR signaling at a glance

Mathieu Laplante et al.

JOURNAL OF CELL SCIENCE (2009)

Article Geriatrics & Gerontology

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

Yiqiang Zhang et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2009)

Review Cell Biology

Molecular mechanisms of mTOR-mediated translational control

Xiaoju Max Ma et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Review Physiology

AMPK in Health and Disease

Gregory R. Steinberg et al.

PHYSIOLOGICAL REVIEWS (2009)

Review Biochemistry & Molecular Biology

TOR complex 2: a signaling pathway of its own

Nadine Cybulski et al.

TRENDS IN BIOCHEMICAL SCIENCES (2009)

Review Cell Biology

Mitochondrially encoded cysteine predicts animal lifespan

Bernd Moosmann et al.

AGING CELL (2008)

Article Cardiac & Cardiovascular Systems

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

Anna Csiszar et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)

Review Biochemistry & Molecular Biology

Ultrastructure of the mitochondrion and its bearing on function and bioenergetics

Giovanni Benard et al.

ANTIOXIDANTS & REDOX SIGNALING (2008)

Article Biochemistry & Molecular Biology

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

Jennifer M. A. Tullet et al.

Review Biochemistry & Molecular Biology

Autophagy in the pathogenesis of disease

Beth Levine et al.

Article Biochemistry & Molecular Biology

AMPK phosphorylation of raptor mediates a metabolic checkpoint

Dana M. Gwinn et al.

MOLECULAR CELL (2008)

Article Multidisciplinary Sciences

Functionally significant insulin-like growth factor I receptor mutations in centenarians

Yousin Suh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Cell Biology

SIRT1 transgenic mice show phenotypes resembling calorie restriction

Laura Bordone et al.

AGING CELL (2007)

Article Biochemistry & Molecular Biology

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C-elegans

Eric L. Greer et al.

CURRENT BIOLOGY (2007)

Review Neurosciences

Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

Vittorio Calabrese et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

IKKβ suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

Dung-Fang Lee et al.

Article Cardiac & Cardiovascular Systems

Vascular aging in the longest-living rodent, the naked mole rat

Anna Csiszar et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)

Article Medicine, General & Internal

Calorie restriction increases muscle mitochondrial biogenesis in healthy humans

Anthony E. Civitarese et al.

PLOS MEDICINE (2007)

Review Biochemistry & Molecular Biology

Bilirubin: an endogenous scavenger of nitric oxide and reactive nitrogen species

Cesare Mancuso et al.

REDOX REPORT (2006)

Article Biochemistry & Molecular Biology

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

DD Sarbassov et al.

MOLECULAR CELL (2006)

Review Cell Biology

Critical nodes in signalling pathways: insights into insulin action

CM Taniguchi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Multidisciplinary Sciences

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

M Kaeberlein et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Disruption of fusion results in mitochondrial heterogeneity and dysfunction

HC Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Extension of murine life span by overexpression of catalase targeted to mitochondria

SE Schriner et al.

SCIENCE (2005)

Article Multidisciplinary Sciences

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

JT Rodgers et al.

NATURE (2005)

Review Biochemistry & Molecular Biology

The plasticity of aging: Insights from long-lived mutants

C Kenyon

Article Multidisciplinary Sciences

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

DD Sarbassov et al.

SCIENCE (2005)

Article Multidisciplinary Sciences

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

RJ Shaw et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Cell Biology

Mitochondrial fission proteins regulate programmed cell death in yeast

Y Fannjiang et al.

GENES & DEVELOPMENT (2004)

Review Cell Biology

The role of oxidative damage and stress in aging

A Bokov et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2004)

Article Multidisciplinary Sciences

Premature ageing in mice expressing defective mitochondrial DNA polymerase

A Trifunovic et al.

NATURE (2004)

Article Biochemistry & Molecular Biology

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

A Woods et al.

CURRENT BIOLOGY (2003)

Article Biochemistry & Molecular Biology

Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells

Y Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

HA Tissenbaum et al.

NATURE (2001)

Review Multidisciplinary Sciences

Cell biology - Autophagy as a regulated pathway of cellular degradation

DJ Klionsky et al.

SCIENCE (2000)

Article Biochemistry & Molecular Biology

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

RA Frye

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

Article Multidisciplinary Sciences

The silencing protein SIR2 and its homologs are MAD-dependent protein deacetylases

J Landry et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)