期刊
BIOCONJUGATE CHEMISTRY
卷 33, 期 11, 页码 2035-2040出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.2c00090
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- Whiting School of Engineering of the Johns Hopkins University
In this work, supramolecular architectures were formed from the assembly of single-tail single stranded DNA (ssDNA)-amphiphiles. The ssDNA-amphiphiles self-assembled into various nanostructures, and the increase of the hydrophobic block led to changes in the structure.
In this work, we demonstrate the formation of supramolecular architectures from the assembly of single-tail single stranded DNA (ssDNA)-amphiphiles. Short ssDNA sequences of 10 nucleotides that were either unstructured or formed G-quadruplex secondary structures were conjugated to a single 4-(hexadecyloxy)benzamide tail, either directly or through a polycarbon (C-12) spacer. Conjugation of the ssDNA to the tail did not interfere with the G-quadruplex secondary structure of the ssDNA sequence. The ssDNA-amphiphiles self-assembled into ellipsoidal micelles, vesicles, nanotapes, and nanotubes. These nanotubes appeared to be formed by the rolling up of nanotapes. The increase of the hydrophobic block of the ssDNA-amphiphiles through the addition of a C-12 spacer led to an increase in wall thickness and nanotube diameter. The presence of pi-pi interactions, through the benzoic group, was verified via X-ray diffraction (XRD) and played a critical role in the formation of the different nanostructures. In contrast, ssDNA-amphiphiles with a single heptadecanoic acid tail self-assembled only into ellipsoidal micelles.
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