☆ 4.4 Review

Two-pore channels: going with the flows

BIOCHEMICAL SOCIETY TRANSACTIONS (2022)

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Article Cell Biology

Acidic Ca2+ stores and immune-cell function

Lianne C. Davis et al.

Summary: Acidic organelles serve as intracellular Ca2+ stores and play important roles in immune-cell function, impacting processes such as membrane trafficking, vesicle fusion/fission, and secretion. Different endo-lysosomal Ca2+ channels on the same vesicles can affect various downstream physiological functions.

CELL CALCIUM (2022)

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Article Multidisciplinary Sciences

Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P-2 and rapamycin

Ninghai Gan et al.

Summary: TRPML1 is a Ca2+-permeable, nonselective cation channel expressed in endolysosomes, which is activated by cooperation between PI(3,5)P2 and rapamycin. The cryoEM structures and electrophysiology studies provide insights into the activation mechanism of TRPML1.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Multidisciplinary Sciences

SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated by multiple physiologically relevant NAD metabolites

Carlo Angeletti et al.

Summary: SARM1 is an important enzyme involved in programmed axon death. It has multiple activities including the highest base exchange activity at neutral pH. The base exchange also occurs in neurons and may be a source of the calcium-mobilizing agent NaADP. The regulation of SARM1 by free pyridines, NADP, and nicotinic acid riboside has therapeutic implications.

ISCIENCE (2022)

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Article Cell Biology

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

Benjamin Chun-Kit Tong et al.

Summary: This study identified a mechanism of impairment in the macroautophagy/autophagy-lysosomal pathway (ALP) in Alzheimer's disease, mediated by the lysosomal TPCN2/TPC2 channel. Targeting TPCN2 was shown to restore lysosomal function and reduce amyloid plaque accumulation, suggesting a potential therapeutic strategy for AD treatment in the future.

AUTOPHAGY (2022)

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Review Medicine, Research & Experimental

Endolysosomal cation channels point the way towards precision medicine of cancer and infectious diseases

Cheng-Chang Chen et al.

Summary: There is growing evidence that ion channels in the endolysosomal system play a crucial role in the pathology of infectious diseases and cancer. This review focuses on the characteristics and functions of endolysosomal cation channels and discusses their importance as potential drug targets.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Cell Biology

Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca2+ stores

Lora L. Martucci et al.

Summary: Ca2+ signaling plays a crucial role in various cell functions in the brain. Acidic Ca2+ stores in different regions of neurons provide local sources of Ca2+ to regulate synaptic transmission and other functions. This review discusses the recruitment mechanism of acidic Ca2+ stores and focuses on the role of endolysosomal two-pore channels (TPCs) and their physiological agonist, as well as their interaction with other receptors. Additionally, this review introduces new pharmacological tools and animal mutant models for studying acidic Ca2+ stores in brain function and dysfunction.

CELL CALCIUM (2022)

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Article Cell Biology

Localized TPC1-mediated Ca2+ release from endolysosomes contributes to myoseptal junction development in zebrafish

Keira L. Rice et al.

Summary: The endolysosomal ion channel TPC1 plays a crucial role in the formation and maintenance of myoseptal junctions (MJs) in developing zebrafish embryos. It generates localized Ca2+ signals that are essential for capturing and attaching slow skeletal muscle cells at MJs. TPC1-decorated endolysosomes are dynamically associated with MJs through a microtubule-dependent mechanism and regulate endolysosomal trafficking and transmembrane protein distribution.

JOURNAL OF CELL SCIENCE (2022)

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Article Cell Biology

Cardiac glycosides stimulate endocytosis of GLUT1 via intracellular Na+,K+-ATPase alpha 3-isoform in human cancer cells

Takuto Fujii et al.

Summary: CGs can inhibit glucose metabolism of cancer cells by inhibiting Na+,K+-ATPase and decreasing the expression of GLUT1. The binding of CGs with intracellular alpha 3NaK elicits NAADP-mediated calcium mobilization.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

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Article Cell Biology

Proton-gated anion transport governs macropinosome shrinkage

Mariia Zeziulia et al.

Summary: Zeziulia et al. identified the proton-activated Cl- channel ASOR/TMEM206 as necessary for the shrinkage of macrophage macropinosomes, which plays a crucial role in sorting and trafficking of cellular organelles. The activation of ASOR requires depolarization mediated by Na+ and acidification by transporters such as H+-ATPases.

NATURE CELL BIOLOGY (2022)

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Review Biochemistry & Molecular Biology

NAADP-binding proteins find their identity

Jonathan S. Marchant et al.

Summary: Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that releases Ca2+ from endosomes and lysosomes by activating two-pore channels (TPCs). Two different NAADP-binding proteins (NAADP-BPs), JPT2 and LSM12, have recently been identified, bridging the gap between NAADP generation and NAADP activation of TPCs. The discovery of these NAADP-BPs will facilitate future studies on the molecular mechanism of NAADP action.

TRENDS IN BIOCHEMICAL SCIENCES (2022)

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Article Cell Biology

Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells

Pawan Faris et al.

Summary: Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates Ca2+ release in lysosomes through dual pore channels 1 and 2, playing an important role in cardiac mesenchymal stromal cells (C-MSCs). These signals are amplified by the Ca2+-induced Ca2+ release mechanism, affecting cell proliferation and signaling.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Cell Biology

Nicotinic acid adenine dinucleotide phosphate activates two-pore channel TPC1 to mediate lysosomal Ca2+release in endothelial colony-forming cells

Francesco Moccia et al.

Summary: The study demonstrates that NAADP-induced TPC1-mediated Ca(2+)release can selectively regulate endothelial functions in circulating ECFCs by mobilizing lysosomal Ca(2+)store.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Biology

TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration

Yanfen Li et al.

Summary: Age-related macular degeneration (AMD) is a common cause of blindness among the elderly, classified as dry or neovascular. Research shows that the endolysosomal two-pore cation channel TPC2 plays a key role in neovascularization and immune activation in AMD, and blocking TPC2 can reduce related factors levels in the pathological process of AMD.

LIFE SCIENCE ALLIANCE (2021)

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Editorial Material Pharmacology & Pharmacy

Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro

Nicola Clementi et al.

PHARMACOLOGICAL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

Eric F. Pettersen et al.

Summary: UCSF ChimeraX is a powerful visualization program with enhanced performance and graphics, offering new tools and analysis features, support for various areas like virtual reality, and improved ease of use, along with an app store for researchers to contribute new tools.

PROTEIN SCIENCE (2021)

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Article Genetics & Heredity

Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect

Julia Bock et al.

Summary: The study provides a comprehensive analysis of the role of the endo-lysosomal cation channel TPC2 in various diseases and traits, including metabolism, obesity, diabetes, infectious diseases, cancer, and pigmentation defects. By identifying a predominant TPC2 variant L564P globally and characterizing its effects on channel activity, along with discovering novel gain-of-function variants, the research sheds light on the ethnic and geographical distribution of TPC2 polymorphisms. Additionally, the study highlights the potential of TPC2 as a pharmacological drug target due to the identified variations in different human populations.

PLOS GENETICS (2021)

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Article Cardiac & Cardiovascular Systems

Oxidation of Protein Kinase A Regulatory Subunit PKARIα Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Lysosomal-Triggered Calcium Release

Jillian N. Simon et al.

Summary: The study revealed that PKARI alpha disulfide formation is significantly increased in response to I/R in both humans and mice, leading to enhanced AKAP binding and preferential localization to the lysosome. This redox-dependent regulation of lysosomal channels by PKARI alpha plays a critical role in protecting the heart from extensive injury and could serve as a novel target for cardioprotective therapeutics.

CIRCULATION (2021)

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Article Biochemistry & Molecular Biology

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation

Feng Gu et al.

Summary: The formation of Ca2+ microdomains during T cell activation is initiated by the production of nicotinic acid adenine dinucleotide phosphate (NAADP) from its reduced form NAADPH. NADPH oxidases NOX and DUOX play crucial roles in this process, with DUOX2 and G6PD catalyzing a redox cycle that rapidly produces and degrades NAADP through NAADPH.

SCIENCE SIGNALING (2021)

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Article Multidisciplinary Sciences

Two-pore channels affect EGF receptor signaling by receptor trafficking and expression

Thomas Mueller et al.

Summary: Two-pore channels (TPCs) play a crucial role in regulating calcium ion currents between endosomes and lysosomes, affecting membrane fusion and fission events as well as intracellular trafficking. The study suggests that TPCs not only regulate the EGFR transportation network, but also influence EGFR signaling and expression.

ISCIENCE (2021)

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Article Biochemistry & Molecular Biology

HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation

Hannes G. Roggenkamp et al.

Summary: This study identified a new NAADP-binding protein, HN1L/JPT2, which connects NAADP formation with the activation of RYR channels, facilitating Ca2+ release. This protein plays a crucial role in the earliest phase of T cell activation.

SCIENCE SIGNALING (2021)

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Article Biochemistry & Molecular Biology

Essential requirement for JPT2 in NAADP-evoked Ca2+ signaling

Gihan S. Gunaratne et al.

Summary: The study identified JPT2 as an essential component of the NAADP receptor complex, required for TPC-dependent Ca2+ signaling and control of coronaviral entry through the endolysosomal system.

SCIENCE SIGNALING (2021)

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Article Multidisciplinary Sciences

Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

Ponsawan Netcharoensirisuk et al.

Summary: Studies have shown an inverse correlation between TPC2 activity in endolysosomes and melanosomes and melanin production, melanoma proliferation, migration, and invasion. Inhibiting TPC2 can increase melanin synthesis in melanosomes by interfering with tyrosinase activity and decrease melanoma progression driven by MITF through GSK3 beta-mediated MITF degradation.

SCIENTIFIC REPORTS (2021)

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Article Cell Biology

NAADP-induced intracellular calcium ion is mediated by the TPCs (two-pore channels) in hypoxia-induced pulmonary arterial hypertension

Wen Hu et al.

Summary: The study investigated the pathogenesis of pulmonary arterial hypertension in rat models and found that two-pore segment channels TPC1/2 play a role in the disease, potentially serving as a therapeutic target.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Multidisciplinary Sciences

Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles

Jiyuan Zhang et al.

Summary: Researchers identified Lsm12 as an NAADP receptor that mediates Ca2+ release from lysosomes via NAADP binding on its Lsm domain. Lsm12 co-localizes with TPC2 and plays a crucial role in NAADP signaling.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Glucose and NAADP trigger elementary intracellular β-cell Ca2+ signals

Paula Maria Heister et al.

Summary: Insulin release from pancreatic beta-cells is associated with highly localized intracellular Ca2+ signals, which may be influenced by global Ca2+ signals and SERCA-based sequestration mechanisms. Previous work has demonstrated the importance of NAADP-induced Ca2+ release in stimulus-secretion coupling in beta-cells.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Physical

The key role of the central cavity in sodium transport through ligand-gated two-pore channels

Stefan Milenkovic et al.

Summary: This article discusses the important role of mammalian two-pore channels in maintaining cellular life processes, particularly the significance of hTPC2 in viral infections. Through molecular simulations, a model for sodium ion transport is proposed.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2021)

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Article Biochemistry & Molecular Biology

Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth

Martin Mueller et al.

Summary: Our study unveils the role of TPC2 in cancer and demonstrates that TPC2 knockout reduces cancer cell proliferation and affects energy metabolism. We have also developed simplified analogs of TPC2 inhibitors with stronger antiproliferative properties against cancer cells.

CELL CHEMICAL BIOLOGY (2021)

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Article Nanoscience & Nanotechnology

A DNA-based voltmeter for organelles

Anand Saminathan et al.

Summary: Voltair is a fluorescent DNA nanodevice that can report the membrane potential of organelles and be targeted to different organelles in live cells. Using Voltair, the membrane potential of various organelles can be measured in real time, potentially guiding the design of biocompatible electronics and enhancing our understanding of how membrane potential regulates organelle biology.

NATURE NANOTECHNOLOGY (2021)

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Article Biology

A two-pore channel protein required for regulating mTORC1 activity on starvation

Fu-Sheng Chang et al.

BMC BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Two-pore channels regulate Tat endolysosome escape and Tat-mediated HIV-1 LTR transactivation

Nabab Khan et al.

FASEB JOURNAL (2020)

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Article Multidisciplinary Sciences

Resting state structure of the hyperdepolarization activated two-pore channel 3

Miles Sasha Dickinson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance

Spencer A. Freeman et al.

SCIENCE (2020)

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A lysosomal K+ channel regulates large particle phagocytosis by facilitating lysosome Ca2+ release

Xue Sun et al.

SCIENTIFIC REPORTS (2020)

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Article Multidisciplinary Sciences

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

Xiuyuan Ou et al.

NATURE COMMUNICATIONS (2020)

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Article Biology

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

Susanne Gerndt et al.

ELIFE (2020)

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Article Biochemistry & Molecular Biology

NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca2+nanodomains, calcineurin and dynamin

Lianne C. Davis et al.

EMBO JOURNAL (2020)

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Review Biochemistry & Molecular Biology

Evolutionary Aspects of TRPMLs and TPCs

Dawid Jaslan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Cell Biology

TPC2-mediated Ca2+ signaling is required for axon extension in caudal primary motor neurons in zebrafish embryos

Chenxi Guo et al.

JOURNAL OF CELL SCIENCE (2020)

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Article Cell Biology

Contribution of NAADP to Glutamate-Evoked Changes in Ca2+Homeostasis in Mouse Hippocampal Neurons

Julia Hermann et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Behavioral Sciences

Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory

Robert Theodor Mallmann et al.

BEHAVIOR GENETICS (2020)

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Article Multidisciplinary Sciences

TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity

Elisabeth Arlt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

Inhibition of two-pore channels in antigen-presenting cells promotes the expansion of TNFR2-expressing CD4+Foxp3+ regulatory T cells

Tianzhen He et al.

SCIENCE ADVANCES (2020)

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Article Chemistry, Physical

The mechanism and energetics of a ligand-controlled hydrophobic gate in a mammalian two pore channel

Stefan Milenkovic et al.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2020)

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Article Cell Biology

Structure and Function of IP3 Receptors

David L. Prole et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2019)

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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

Xiaoli Zhang et al.

PLOS BIOLOGY (2019)

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Structural mechanisms of phospholipid activation of the human TPC2 channel

Ji She et al.

ELIFE (2019)

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Review Biochemistry & Molecular Biology

Resolving the topological enigma in Ca2+ signaling by cyclic ADP-ribose and NAADP

Hon Cheung Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

The protein interaction networks of mucolipins and two-pore channels

Einar K. Krogsaeter et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers

Christopher J. Penny et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

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Article Developmental Biology

Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos

Jeffrey J. Kelu et al.

DEVELOPMENTAL BIOLOGY (2019)

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A pH-correctable, DNA-based fluorescent reporter for organellar calcium

Nagarjun Narayanaswamy et al.

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Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels

Xiaoli Zhang et al.

ELIFE (2019)

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Sandip Patel et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

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Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2

Sonja A. Kirsch et al.

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Two-pore channels mediated receptor-operated Ca2+ entry in pulmonary artery smooth muscle cells in response to hypoxia

Yongliang Jiang et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

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Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel

Ji She et al.

NATURE (2018)

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Tpcn2 knockout mice have improved insulin sensitivity and are protected against high-fat diet-induced weight gain

Hong He et al.

PHYSIOLOGICAL GENOMICS (2018)

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mTORC1 controls lysosomal Ca2+ release through the two-pore channel TPC2

Oluseye A. Ogunbayo et al.

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mTORC1 controls lysosomal Ca2+ release through the two-pore channel TPC2

Oluseye A. Ogunbayo et al.

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NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system

Gihan S. Gunaratne et al.

CELL CALCIUM (2018)

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A screening campaign in sea urchin egg homogenate as a platform for discovering modulators of NAADP-dependent Ca2+ signaling in human cells

Gihan S. Gunaratne et al.

CELL CALCIUM (2018)

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Article Biochemistry & Molecular Biology

Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling

William J. Foster et al.

SCIENCE SIGNALING (2018)

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Article Oncology

Glutamate induces autophagy via the two-pore channels in neural cells

Gustavo J. S. Pereira et al.

ONCOTARGET (2017)

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Article Biochemistry & Molecular Biology

Synthesis of the Ca2+ - mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling

Wee K. Lin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

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Article Cell Biology

A voltage-dependent K+ channel in the lysosome is required for refilling lysosomal Ca2+ stores

Wuyang Wang et al.

JOURNAL OF CELL BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Liposomes as a Putative Tool to Investigate NAADP Signaling in Vasculogenesis

Francesca Di Nezza et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

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Article Multidisciplinary Sciences

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms

Yu-Kai Chao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart

Daniel Aston et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

The human two-pore channel 1 is modulated by cytosolic and luminal calcium

Laura Lagostena et al.

SCIENTIFIC REPORTS (2017)

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Article Cell Biology

An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

Bethan S. Kilpatrick et al.

CELL REPORTS (2017)

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Article Multidisciplinary Sciences

Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis

Irene Pafumi et al.

SCIENTIFIC REPORTS (2017)

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The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes

Jan Castonguay et al.

SCIENTIFIC REPORTS (2017)

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Article Oncology

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells

Ong Nam Phuong Nguyen et al.

CANCER RESEARCH (2017)

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Brain Disorders Due to Lysosomal Dysfunction

Alessandro Fraldi et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 39 (2016)

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Differential effects of two-pore channel protein 1 and 2 silencing in MDA-MB-468 breast cancer cells

Aisyah H. Jahidin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Ca2+ dialogue between acidic vesicles and ER

Anthony J. Morgan

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Endoplasmic reticulum and lysosomal Ca2+ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts

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Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition

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Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level

Vanessa Garcia-Rua et al.

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Ca2+/H+ exchange by acidic organelles regulates cell migration in vivo

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TPC2 controls pigmentation by regulating melanosome pH and size

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NAADP-Dependent Ca2+ Signaling Controls Melanoma Progression, Metastatic Dissemination and Neoangiogenesis

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Isolated pores dissected from human two-pore channel 2 are functional

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Claire Shuk-Kwan Lee et al.

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The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes

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Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation

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TPC: the NAADP discovery channel?

Anthony J. Morgan et al.

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Article Cardiac & Cardiovascular Systems

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore

Sean M. Davidson et al.

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Article Biochemistry & Molecular Biology

TMEM175 Is an Organelle K+ Channel Regulating Lysosomal Function

Chunlei Cang et al.

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Departure gate of acidic Ca2+ confirmed

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