期刊
BIOCHEMICAL PHARMACOLOGY
卷 201, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2022.115074
关键词
Amino acid transport; Liver; Hepatocyte; Gluconeogenesis; Metabolic zonation; Amino acid signalling; mTORC1
资金
- Netherlands Organiza-tion for Scientific Research [09150182010007]
- Australian Research council [DP180101702]
The liver controls the exposure of amino acids entering via the gastrointestinal tract, but it is still unclear which transporters are involved in hepatocellular amino acid transport.
The liver controls the systemic exposure of amino acids entering via the gastro-intestinal tract. For most amino acids except branched chain amino acids, hepatic uptake is very efficient. This implies that the liver orchestrates amino acid metabolism and also controls systemic amino acid exposure. Although many amino acid transporters have been identified, cloned and investigated with respect to substrate specificity, transport mechanism, and zonal distribution, which of these players are involved in hepatocellular amino acid transport remains unclear. Here, we aim to provide a review of current insight into the molecular machinery of hepatic amino acid transport. Furthermore, we place this information in a comprehensive overview of amino acid transport, signalling and metabolism.
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