Circ_0005925 Promotes Granulosa Cell Growth by Targeting MiR-324-3p to Upregulate MAP2K6 in Polycystic Ovary Syndrome

Article Cell Biology

CircASPH promotes KGN cells proliferation through miR-375/MAP2K6 axis in Polycystic Ovary Syndrome

Gengxiang Wu et al.

Summary: The study investigated the expression levels of circASPH, miR-375, and MAP2K6 in PCOS patients and their interactions, revealing that circASPH promotes KGN cell proliferation through the miR-375/MAP2K6 axis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2022)

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Article Medicine, General & Internal

Identification of Three Potential circRNA Biomarkers of Polycystic Ovary Syndrome by Bioinformatics Analysis and Validation

Pengyu Huang et al.

Summary: This study aimed to investigate the potential diagnostic value of circRNAs in PCOS through analyzing datasets from the GEO database. The construction of a ceRNA network revealed dysregulated circRNAs in PCOS, suggesting their potential use as diagnostic biomarkers. Further research is needed to explore the specific regulatory mechanisms of these circRNAs in PCOS.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2021)

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Review Biotechnology & Applied Microbiology

Circular RNAs: Expression, localization, and therapeutic potentials

Qiwei Yang et al.

Summary: Circular RNAs (circRNAs) are RNAs with a unique circular structure that possess important regulatory functions in cellular events. Besides cancer, many circRNAs are also involved in the developmental stages of non-cancer diseases.

MOLECULAR THERAPY (2021)

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Article Orthopedics

CircRNA-MSR Regulates LPS-Induced C28/I2 Chondrocyte Injury through miR-643/MAP2K6 Signaling Pathway

Zhen Jia et al.

Summary: The study found that circRNA-MSR can upregulate MAP2K6 by targeting miR-643, thereby inhibiting proliferation and promoting apoptosis of C28/I2 cells. This provides a new therapeutic target for future OA treatment.

CARTILAGE (2021)

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Article Veterinary Sciences

chi-miR-324-3p Regulates Goat Granulosa Cell Proliferation by Targeting DENND1A

Yufang Liu et al.

Summary: GC proliferation is essential for ovulation in animals, and DENND1A is identified as a significant factor in polycystic ovary syndrome. The study demonstrates that chi-miR-324-3p inhibits GC proliferation by targeting DENND1A, as validated through various experiments.

FRONTIERS IN VETERINARY SCIENCE (2021)

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Article Biotechnology & Applied Microbiology

Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis

Xiaohui Lu et al.

Summary: PCOS is a complex endocrine disorder affecting many women, and circRNAs such as circ_RANBP9 play a role in its development. In this study, increased levels of circ_RANBP9 were found in PCOS patients and ovarian granulosa cells, and its silencing inhibited cell proliferation and promoted apoptosis by mediating the miR-136-5p/XIAP pathway. These findings provide new insights into potential therapeutic targets for PCOS.

BIOENGINEERED (2021)

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Article Biochemical Research Methods