期刊
BIOCHEMICAL GENETICS
卷 61, 期 1, 页码 35-47出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10528-022-10236-1
关键词
Glioma; miR-212-5p; Proliferation; Migration
This study suggests that miR-212-5p plays a suppressive role in glioma development by regulating the expression of SUMO2, thereby affecting the proliferation, migration, and apoptosis of glioma cells. This finding may contribute to the identification of novel therapeutic targets for glioma.
Recently, increasing studies have suggested that miRNAs play a significant role in the occurrence and development of glioma. More researches are needed to explore the role of miRNAs in glioma, which will help to find new therapeutic targets. miR-212-5p has been reported to be involved in the progression in many cancers. However, whether miR-212-5p has a regulative effect on glioma remains un clear. In this study, we aimed to explore the effect of miR-212-5p on glioma development and its mechanism. Here, we demonstrated that miR-212-5p was lowly expressed in glioma cell. miR-212-5p suppressed the glioma cell proliferation, inhibited the migratory and invasive capabilities and promoted apoptosis in glioma cells. Besides, miR-212-5p also inhibited tumor growth in vivo. We found small ubiquitin-like modifier 2 (SUMO2) was the target of miR-212-5p, and miR-212-5p suppressed SUMO2 expression to regulate the proliferation, migration, and apoptosis of glioma cells. These findings indicated that miR-212-5p may be a possible therapeutic target for the treatment for glioma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据