4.6 Article

CSTA plays a role in osteoclast formation and bone resorption by mediating the DAP12/TREM2 pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Endocrinology & Metabolism

Bariatric Surgery and Osteoporosis

Julien Paccou et al.

Summary: Bariatric surgery has been increasingly recognized to adversely affect skeletal health, leading to high-turnover bone loss, deterioration in bone microarchitecture, and increased fracture risk. Factors such as nutrition, mechanical unloading, gut hormones, adipokines, and bone marrow adiposity may contribute to these effects. Selecting the most appropriate bariatric procedure and ensuring sufficient calcium, vitamin D, protein intake, and physical activity are important in mitigating negative impacts on bone health. Further research is needed to understand the mechanisms and potential treatments for high-turnover bone loss after bariatric surgery.

CALCIFIED TISSUE INTERNATIONAL (2022)

Article Neurosciences

Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response

Xin Cui et al.

Summary: Research revealed that the TREM2/DAP12 complex inhibits microglial inflammatory responses through the JNK signaling pathway, leading to reduced deposition of A beta plaques and attenuation of behavioral manifestations in a mouse AD model.

BRAIN RESEARCH BULLETIN (2021)

Review Biochemistry & Molecular Biology

Mechanisms of Bone Fragility: From Osteogenesis Imperfecta to Secondary Osteoporosis

Ahmed El-Gazzar et al.

Summary: The strength of bone material is determined by various factors, and understanding the mechanisms of rare genetic bone fragility disorders not only advances medical knowledge but also may lead to drug development for more common disorders. The main disease mechanisms underlying bone fragility associated with low bone mass include type I collagen processing, WNT signaling, TGF-β signaling, the RANKL-RANK system, and the osteocyte mechanosensing pathway.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Endocrinology & Metabolism

RANKL as the master regulator of osteoclast differentiation

Hiroshi Takayanagi

Summary: RANKL is the essential cue for osteoclast differentiation, playing a critical role through distinct signaling pathways mediated by co-stimulatory receptors and the key transcription factor NFATc1.

JOURNAL OF BONE AND MINERAL METABOLISM (2021)

Review Medicine, General & Internal

Testosterone and Bone Health in Men: A Narrative Review

Kazuyoshi Shigehara et al.

Summary: Bone fracture due to osteoporosis is a significant issue for elderly men, and testosterone replacement therapy has shown benefits in improving bone mineral density in symptomatic hypogonadal men with osteopenia.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Biochemistry & Molecular Biology

Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment

Yuteng Weng et al.

Summary: Periodontitis is the sixth most prevalent disease globally, closely related to systemic diseases and impacting overall health. It is characterized by irreversible alveolar bone loss and activated osteoclastogenic process, which may be linked to the activation of intracellular reactive oxygen species (ROS) in osteoclasts.

REDOX BIOLOGY (2021)

Article Medicine, Research & Experimental

Bone-Targeting AAV-Mediated Gene Silencing in Osteoclasts for Osteoporosis Therapy

Yeon-Suk Yang et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

Review Biochemistry & Molecular Biology

Molecular Mechanisms and Emerging Therapeutics for Osteoporosis

Ji-Yoon Noh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis

Laura Gambari et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

F2r negatively regulates osteoclastogenesis through inhibiting the Akt and NFκB signaling pathways

Yan Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

Review Immunology

Immune Function and Diversity of Osteoclasts in Normal and Pathological Conditions

Maria-Bernadette Madel et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Endocrinology & Metabolism

Update on Menopausal Hormone Therapy for Fracture Prevention

Jan J. Stepan et al.

CURRENT OSTEOPOROSIS REPORTS (2019)

Review Endocrinology & Metabolism

Combination therapies in the treatment of osteoporosis

Jennifer J. Kelly et al.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2019)

Article Biochemistry & Molecular Biology

From macrophage to osteoclast - How metabolism determines function and activity

Katharina F. Kubatzky et al.

CYTOKINE (2018)

Review Biochemistry & Molecular Biology

The Sealing Zone in Osteoclasts: A Self-Organized Structure on the Bone

Jiro Takito et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Oncology

The biology of normal bone remodelling

P. Katsimbri

EUROPEAN JOURNAL OF CANCER CARE (2017)

Article Endocrinology & Metabolism

DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis

Xiaofeng Cai et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2017)

Article Geriatrics & Gerontology

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

Li Zhong et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

Review Allergy

A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts

Mary Beth Humphrey et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2016)

Article Geriatrics & Gerontology

Identification of crucial genes related to postmenopausal osteoporosis using gene expression profiling

Min Ma et al.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2016)

Review Pharmacology & Pharmacy

The safety and tolerability profile of therapies for the prevention and treatment of osteoporosis in postmenopausal women

Barry S. Komm et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2015)

Article Immunology

Structure, expression pattern and biological activity of molecular complex TREM-2/DAP12

Agnieszka Paradowska-Gorycka et al.

HUMAN IMMUNOLOGY (2013)

Article Endocrinology & Metabolism

Changes in Bone Resorption Across the Menopause Transition: Effects of Reproductive Hormones, Body Size, and Ethnicity

MaryFran R. Sowers et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Multidisciplinary Sciences

DAP12 Overexpression Induces Osteopenia and Impaired Early Hematopoiesis

Genevieve Despars et al.

PLOS ONE (2013)

Review Immunology

Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

Takako Negishi-Koga et al.

IMMUNOLOGICAL REVIEWS (2009)

Article Endocrinology & Metabolism

TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function

MB Humphrey et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2006)

Article Multidisciplinary Sciences

The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase

A Mócsai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Immunology

Impaired differentiation of osteoclasts in TREM-2-deficient individuals

M Cella et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

Article Immunology

DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features

J Paloneva et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)