Secretory autophagy during lysosome inhibition (SALI)

Summary: The endolysosome system is involved in autophagic degradation and secretory pathways, including the release of extracellular vesicles and particles (EVPs). This study reveals a secretory autophagy pathway that is upregulated during endolysosome inhibition and mediates the release of autophagic cargo receptors via EVPs. This secretion process is regulated by multiple ATGs and the small GTPase Rab27a.