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Article
Biochemistry & Molecular Biology
DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron depletion
Maeve Long et al.
Summary: Mitophagy removes defective mitochondria through lysosomal elimination. Iron depletion triggers lipid metabolism remodeling and lipid droplets bordering mitochondria. Inhibiting DGAT1 restricts mitophagy and leads to cell death.
EMBO JOURNAL (2022)
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