期刊
AURIS NASUS LARYNX
卷 50, 期 2, 页码 276-284出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.anl.2022.06.002
关键词
COVID-19; Tracheostomy; Mechanical ventilation; Prognosis
This study aimed to evaluate the association between tracheostomy and prognosis in patients with COVID-19 requiring prolonged mechanical ventilation (PMV). The study found that tracheostomy significantly reduced hospital mortality and also decreased ICU and 28-day mortality in COVID-19 patients. Sensitivity analysis consistently showed reduced mortality in patients who underwent tracheostomy.
Objective: Tracheostomy is a common procedure with potential prognostic advantages for pa-tients who require prolonged mechanical ventilation (PMV). Early recommendations for patients with coronavirus disease 2019 (COVID-19) suggested delayed or limited tracheostomy consid-ering the risk for viral transmission to clinicians. However, updated guidelines for tracheostomy with appropriate personal protective equipment have revised its indications. This study aimed to evaluate the association between tracheostomy and prognosis in patients with COVID-19 requir-ing PMV.Methods: This was a multicenter, retrospective cohort study using data from the nationwide Japanese Intensive Care PAtient Database. We included adult patients aged >= 16 years who were admitted to the intensive care unit (ICU) due to COVID-19 and who required PMV (for > 14 days or until performance of tracheostomy). The primary outcome was hospital mortality, and the association between implementation of tracheostomy and patient prognosis was assessed using weighted Cox proportional hazards regression analysis with inverse probability of treatment weighting (IPTW) using the propensity score to address confounders.Results: Between January 2020 and February 2021, 453 patients with COVID-19 were observed. Data from 109 patients who required PMV were analyzed: 66 (60.6%) underwent tracheostomy and 38 (34.9%) died. After adjusting for potential confounders using IPTW, tracheostomy imple-mentation was found to significantly reduce hospital mortality (hazard ratio [HR]: 0.316, 95% confidence interval [CI]: 0.163-0.612). Patients who underwent tracheostomy had a similarly decreased ICU and 28-day mortality (HR: 0.269, 95% CI: 0.124-0.581; HR 0.281, 95% CI: 0.094-0.839, respectively). A sensitivity analysis using different definitions of PMV duration consistently showed reduced mortality in patients who underwent tracheostomy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据