期刊
ARCHIVES OF MICROBIOLOGY
卷 204, 期 7, 页码 -出版社
SPRINGER
DOI: 10.1007/s00203-022-03026-1
关键词
Probiotic; Lactobacillus; Bifidobacterium; Gap junctions; Cx26; Cx43
类别
资金
- Science and Research Branch of Islamic Azad University
- Bacteriology Department of Pasteur Institute of Iran [1694]
This study aimed to investigate the impact of Lactobacillus and Bifidobacterium strains on cell junctions. The results showed that these strains were able to regulate the expression of cell junctions in the presence of pathogens. This is important for maintaining intestinal homeostasis and preventing inflammation symptoms.
Probiotics are special bacterial strains with strain specific impacts. They can affect health condition in intestine by producing organic acid, competing with pathogens and maintaining cells homeostasis. Regarding to importance of cell junctions in cells transportation and the influence of pathogens in their functions which lead to inflammation, the impact of probiotic strains comprised of Lactobacillus and Bifidobacterium strains on two important members of gap junctions (Cx26 and Cx43) were assayed. The expressions of cell junction genes in contact with probiotic cocktail along with pathogenic components of enterotoxigenic Escherichia coli and Salmonella typhimurium on HT-29 cell line in different treatment orders were evaluated. Results analysis demonstrated downregulation of cx26 and cx43 along with pathogenic components while, probiotic cocktail could modulate their expression by upregulation. We concluded that Lactobacillus and Bifidobacterium strains were efficient probiotics, when they were used as one cocktail, impacted grater amount on the expression of cell junctions and this might lead to modulate homeostasis and reveal inflammation symptoms in intestine.
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