期刊
APPLIED ORGANOMETALLIC CHEMISTRY
卷 36, 期 10, 页码 -出版社
WILEY
DOI: 10.1002/aoc.6862
关键词
amino acids; cobalt(II) complexes; copper(II) complexes; cytotoxic activity; Schiff base proligands
资金
- National Science Fund, Ministry of Education and Science in Bulgaria [NoKOCT 01/10]
- Romanian Academy
- Bulgarian Academy of Sciences
Two new families of Cu(II) and Co(II) mononuclear complexes with mixed ligands were successfully synthesized and characterized. Biological evaluation showed that these complexes exhibit cytotoxic effects on HeLa and LSR-SF-SR cells.
Two new families of Cu(II) and Co(II) mononuclear complexes with mixed ligands, [Cu(VanTrpt)(bipy)]center dot MeOH (CuVanTrpt), [Cu(VanSer)(bipy)]center dot 4H(2)O (CuVanSer), [Cu(VanTyr)(bipy)]center dot H2O (CuVanTyr), [Cu(VanThr)(bipy)]center dot MeOH (CuVanThr), [Co(VanTrpt)(bipy)(OH2)]center dot H2O center dot MeOH (CoVanTrpt), [Co(VanSer)(bipy)(OH2)]center dot MeOH (CoVanSer), [Co(VanTyr)(bipy)(OH2)]center dot 3H(2)O center dot MeOH (CoVanTyr), and [Co(VanThr)(bipy)(OH2)] (CoVanThr), (VanX are Schiff base proligands resulted from the condensation of o-vanillin with D,L-tryptophan (VanTrpt), L-serine (VanSer), L-tyrosine (VanTyr), and L-threonine (VanThr), respectively, and bipy is 2,2'-bipyridine), have been obtained and characterized on the basis of elemental analysis, magnetic measurements, and spectral data (FT-IR and UV-Vis-Nir spectroscopy). Crystal structures of CuVanTrpt, CuVanSer, and CuVanTyr have been solved by single-crystal X-Ray diffraction. Biological evaluation revealed that they are cytotoxic in HeLa (human carcinoma of the uterine cervix) and LSR-SF-SR (rat sarcoma induced by Rous sarcoma virus strain Schmidt-Ruppin) cells, showing an enhancement of cytotoxicity dependent of concentration and treatment time. The most pronounced cytotoxic effect is expressed by CuVanSer and CoVanSer. Various cytopathological changes of both types of cancer cells were observed after treatment with Cu(II) and Co(II) complexes for 72 h at concentrations of 100 and 200 mu g ml(-1). LSR-SF-SR cells were found to be relatively more sensitive to the cytotoxic effect of the complexes investigated as compared to HeLa cells.
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