CpXCo(III)-catalyzed selective C-H alkenylation of indoles with ethynylethylene carbonates

An efficient and selective insertion of indoles into ethynylethylene carbonates has been achieved via (CpCo)-Co-X(III)-catalyzed C-H functionalization. Compared with a Cp*Co(III) catalyst, the more sterically hindered (CpCo)-Co-X(III) improved the selectivity of rare 1,2-insertion. This protocol provides an approach for synthesizing various vinylindoles in good yields with high regioselectivity.

Automated summary

An efficient and selective C-H functionalization reaction of indoles into ethynylethylene carbonates has been achieved via (CpCo)-Co-X(III) catalysis, allowing the synthesis of various vinylindoles with high yields and regioselectivity.