期刊
ANTIVIRAL RESEARCH
卷 206, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.antiviral.2022.105398
关键词
Lipid droplet; Lysosome; Flavivirus; Coronavirus; Replication organelle; Lipid metabolism
资金
- PRIN, Bando 2017 [2017KM79 NN]
- Horizon 2020 Framework Programme I -GENE [2020KSY3KL]
- PRIN, bando 2020 [2020KSY3KL]
- European call identifier H2020-FETOPEN-2018-2020 [862714]
- University of Pisa [PRA_2020_37, PRA_2020_32]
In cells infected by single stranded positive-sense RNA viruses, a marked reorganization of internal membranes occurs, leading to changes in cell compartments to provide lipids for membrane rearrangement into replication organelles. This increased lipid consumption is achieved through lipolysis and lipophagy of lipid droplets.
A marked reorganization of internal membranes occurs in the cytoplasm of cells infected by single stranded positive-sense RNA viruses. Most cell compartments change their asset to provide lipids for membrane rear-rangement into replication organelles, where to concentrate viral proteins and enzymes while hiding from pathogen pattern recognition molecules. Because the endoplasmic reticulum is a central hub for lipid meta-bolism, when viruses hijack the organelle to form their replication organelles, a cascade of events change the intracellular environment. This results in a marked increase in lipid consumption, both by lipolysis and lip-ophagy of lipid droplets. In addition, lipids are used to produce energy for viral replication. At the same time, inflammation is started by signalling lipids, where lysosomal processing plays a relevant role. This review is aimed at providing an overview on what takes place after human class IV viruses have released their genome into the host cell and the consequences on lipid metabolism, including lysosomes.
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