4.7 Article

Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance

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AMER SOC MICROBIOLOGY
DOI: 10.1128/aac.00621-22

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SCV; antibiotic resistance; tobramycin; gentamicin; burn wound infection; Pseudomonas aeruginosa; small-colony variant; aminoglycosides

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  1. Stiftung fur die Forschung in Anasthesiologie und Intensivmedizin [32/2019]

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This study reports a case of small-colony variant (SCV) emergence of Pseudomonas aeruginosa in a patient undergoing aminoglycoside treatment for burn wound infection, and confirms the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. The involvement of IspA in ubiquinone synthesis provides a possible link between electron transport and SCV formation in P. aeruginosa.
Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. IspA is involved in the synthesis of ubiquinone, providing a possible link between electron transport and SCV formation in P. aeruginosa.

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